Diabetes News

Impact of Statins on the Coagulation Status of Type 2 Diabetes Patients Evaluated by a Novel Thrombin-Generation Assay
The use of a standardized, easy-to-run, and commercially available APC-dependent thrombin-generation assay detected the presence of a procoagulant status in a large series of patients with long-standing T2D and demonstrated a significant impact of statins in the coagulation status of patients with T2D (Cardiovascular Drugs and Therapy)

Thrombin generation in type 2 diabetes with albuminuria and macrovascular disease
Our results support the hypothesis that TG may be involved in the pathogenesis of MVD in diabetic nephropathy as for the first time, we could show that patients with T2DM in different stages of diabetic nephropathy had disturbances in thrombin generation (European Journal of Clinical Investigation)

Effects of a combination of oral anti-diabetes drugs with basal insulin therapy on ß-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes
In newly diagnosed type 2 diabetes, therapy with oral drugs+insulin has had favourable outcomes on recovery and maintenance of ß-cell function and protracted glycaemic remission compared with treatment with oral drugs alone (Diabetes/Metabolism Research and Reviews)

Management of hyperglycaemia in type 2 diabetes
A patient-centered approach. Position statement of the American Diabetes Association and the European Association for the Study of Diabetes (Diabetologia)

Association between tamoxifen treatment and diabetes
Current tamoxifen therapy is associated with an increased incidence of diabetes in older breast cancer survivors. These findings suggest that tamoxifen treatment may exacerbate an underlying risk of diabetes in susceptible women (Cancer)

Sensorineural hearing loss is a common finding in early onset type 2 diabetes
Patients with early onset T2DM and poor glycemic control have an increased prevalence of subclinical hearing loss and impaired auditory brainstem responses. Hearing impairment may be an under-recognized complication of diabetes (Endocrine Practice)

Protein tyrosine phosphatase 1B inhibitors: A molecular level legitimate approach for the management of diabetes mellitus
The drug discovery research in PTP 1B is a challenging area to work with and many pharmaceutical organizations and academic research laboratories are focusing their research toward the development of potential PTP 1B inhibitors which would prove to be a milestone for the management of diabetes (Medicinal Research Reviews)

Chronic Kidney Disease, Insulin Resistance, and Incident Diabetes in Older Adults
Among older adults, lower eGFR was associated with insulin resistance. However, with lower eGFR, ß cell function was appropriately augmented and risks of impaired glucose tolerance and incident diabetes were not increased (Clinical journal of the American Society of Nephrology)

Changes in Treatment Adherence and Glycemic Control During the Transition to Adolescence in Type 1 Diabetes
The magnitude of the effect of declining treatment adherence (blood glucose monitoring frequency – BGMF) on glycemic control in young adolescents may be even greater than declines observed among older adolescents. BGMF offers a powerful tool for targeted management of glycemic control for type 1 diabetes during the critical transition to adolescence (Diabetes Care)

Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy
This pilot data demonstrates an excitatory/inhibitory neurotransmitter imbalance in the brain of in patients with DN and positive sensory symptoms compared to pain free HC subjects (Academic Radiology)

Do Twin Pregnant Women Require Twice as Much Insulin as Singleton Pregnant Women?
In twin pregnancies, the weekly increase in insulin dose between 14 and 27 weeks was doubled compared with singleton pregnancies (Diabetes Care)

Does Diabetes Care Differ by Type of Chronic Comorbidity?
Our study indicates that diabetes care varies by types of comorbidity. Concordant illnesses result in similar or better care, regardless of visit frequency. Discordant illnesses are associated with diminished care: an effect that decreases as visit frequency increases (Diabetes Care)

Stratifying healthcare costs using the Diabetes Complication Severity Index
The DCSI score is a useful tool for predicting direct healthcare costs. The DCSI can be used to triage high-risk patients for more focused secondary prevention interventions at primary care level, in a bid to lower overall healthcare costs (Diabetes and Its Complications)

Societal correlates of diabetes prevalence: An analysis across 94 countries
Macro-level societal factors are associated with diabetes prevalence. Investigating how these factors affect individual-level diabetes risk may offer further insight into policy-level interventions (Diabetes Research and Clinical Practice)

Initial therapy with the fixed-dose combination of sitagliptin and metformin
Compared with pioglitazone, initial therapy with a FDC of sitagliptin and metformin led to significantly greater improvement in glycaemic control as well as a higher incidence of prespecified gastrointestinal adverse events, a lower incidence of oedema and weight loss vs. weight gain (Diabetes, Obesity and Metabolism)

Trial of Intravitreal Bevacizumab or Laser Therapy (BOLT) in the Management of Diabetic Macular Edema
This study provides evidence supporting longer-term use of intravitreous bevacizumab for persistent center-involving CSME (Archives of Ophthalmology)

First ever mandatory care standards bring hope of improved care for children and young people with diabetes
Set by leading paediatric doctors, nurses and commissioners, working in partnership with NHS Diabetes, the ‘Best Practice Tariff for Paediatric Diabetes’ sets out 13 mandatory care standards1 for paediatric diabetes service teams to meet (NHS Diabetes)

Diabetes Outcomes Versus Expenditure Tool (DOVE)
The Diabetes Outcomes Versus Expenditure (DOVE) tool allows users to compare expenditure on diabetes care with clinical outcomes for a selected PCT, other PCTs with similar populations and all other PCTs. Spending on diabetes care can be compared to a number of outcomes at PCT level (Yorkshire and Humber Public Health Observatory)

Implementing key therapeutic topics: Type 2 diabetes
These bulletins summarise the evidence-base for the therapeutic topics reviewed, and contrast this with the prescribing data available for these topics (MeReC Bulletin

Prevalence of abnormal plasma liver enzymes in older people with Type 2 diabetes
The prevalence of elevated liver enzymes in people with Type 2 diabetes is high, with only modest variation between clinically defined patient groups. Further research is required to determine the prognostic value of raised, routinely measured liver enzymes to inform decisions on appropriate follow-up investigations (Diabetic Medicine)

Alcohol consumption and risk of pre-diabetes and type 2 diabetes development in a Swedish population
High alcohol consumption increases the risk of abnormal glucose regulation in men. In women the associations are more complex: decreased risk with low or medium intake and increased risk with high alcohol intake (Diabetic Medicine)

Estimated morbidity and mortality in adolescents and young adults diagnosed with Type 2 diabetes mellitus
Adolescents/young adults with Type 2 diabetes lose approximately 15 years from average RLE and may experience severe, chronic complications of Type 2 diabetes by their 40s. A comprehensive management plan that includes early and aggressive control of cardiovascular risk factors is likely needed to reduce lifetime risk of CHD (Diabetic Medicine)

Evaluation of renal biopsies in type 2 diabetic patients with kidney disease: a clinicopathological study of 216 cases
Our results indicated that the clinical manifestations and pathologic findings in type 2 diabetic patients in different age groups have different features. This study emphasized the usefulness of renal biopsy for determining the pattern of renal damage and thus for the overall management of type 2 diabetic patients (International Urology and Nephrology)

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts
This is the first robustly replicated common susceptibility locus found to be associated with metformin treatment response (Diabetologia)

Gestational diabetes and pregnancy outcomes. a systematic review of WHO and IADPSG diagnostic criteria
The WHO and the IADPSG criteria for GDM identified women at a small increased risk for adverse pregnancy outcomes (BMC Pregnancy and Childbirth)

Apelin, a promising target for type 2 diabetes treatment?
In this review, we describe the various metabolic functions that are affected by apelin and we present an integrated overview of recent findings that collectively propose apelin as a promising target for the treatment of T2DM (Trends in Endocrinology & Metabolism)

Interaction between glycaemic control and serum insulin-like growth factor 1 on the risk of retinopathy in type 2 diabetes
Our data suggested serum IGF-1 was a contributing factor in severe diabetic retinopathy and this effect may be masked by poor glycaemic control (European Journal of Clinical Investigation)

Perspectives of patients with type 1 or insulin-treated type 2 diabetes on self-monitoring of blood glucose

From the patients’ perspective, professionals positively present SMBG as a ‘friend’ in order to achieve strict glycemic control. Whereas patients can also perceive SMBG as a ‘foe’ (BMC Public Health)

Variation of Fasting Plasma Glucose: A Predictor of Mortality in Patients with Type 2 Diabetes
Time-dependent variation of FPG was a strong predictor of all-cause, expanded, and nonexpanded cardiovascular disease-related mortality in patients with type 2 diabetes, suggesting that glucose variation may become a measure in clinical practice for the goal in the management of these patients (American Journal of Medicine)

Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes
In obese patients with uncontrolled type 2 diabetes, 12 months of medical therapy plus bariatric surgery achieved glycemic control in significantly more patients than medical therapy alone. Further study will be necessary to assess the durability of these results (New England Journal of Medicine)

Remission of Insulin Resistance in Type 2 Diabetic Patients After Gastric Bypass Surgery or Exenatide Therapy
Gastric bypass surgery is better in weight control and in the remission of insulin resistance compared with exenatide therapy (Obesity Surgery)

Early Neurodegeneration in the Retina of Type 2 Diabetic Patients
This study demonstrates thinner inner retinal layers in the macula of type 2 diabetic patients with minimal DR than in controls. These results support the concept that early DR includes a neurodegenerative component (Investigative Ophthalmology & Visual Science)

Effect of Diabetes Mellitus on Severity and Hospital Mortality in Patients With Acute Pancreatitis
Although diabetes may adversely affect the disease process of AP, it seems to protect patients from AP-related mortality (Diabetes Care)

BYETTA® Approved for Use with Basal Insulin in Europe
Amylin Pharmaceuticals and Eli Lilly and Company announced that the European Commission has granted marketing authorization to BYETTA® (exenatide twice-daily) as an adjunctive therapy to basal insulin, with or without metformin and/or Actos® (pioglitazone), for the treatment of type 2 diabetes in adults who have not achieved adequate glycemic control with these agents (Lilly)

Effects of Dapagliflozin, a Sodium-Glucose Cotransporter-2 Inhibitor, on Hemoglobin A1c, Body Weight, and Hypoglycemia Risk in Patients With Type 2 Diabetes Inadequately Controlled on Pioglitazone Monotherapy
In patients with type 2 diabetes inadequately controlled on pioglitazone, the addition of dapagliflozin further reduced HbA1c levels and mitigated the pioglitazone-related weight gain without increasing hypoglycemia risk (Diabetes Care)

Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial
In treatment-naïve patients with T2D, dapagliflozin plus metformin was generally well tolerated and effective in reducing HbA1c, FPG and weight. Dapagliflozin-induced glucosuria led to an increase in events suggestive of urinary tract and genital infections (International Journal of Clinical Practice)

Effects of bezafibrate on lipid and glucose metabolism in dyslipidemic patients with diabetes: the J-BENEFIT study
Bezafibrate significantly improved HbA1c in patients with diabetes given individualized treatment. Bezafibrate may offer clinicians an improved modality for the amelioration of disease course and improvement of outcome in these patients (Cardiovascular Diabetology)

QiC Programme Diabetes
Entries are invited from anyone working in the diabetes arena. Whatever the area of patient care, if your initiative or programme relates to diabetes in any way, you should enter it. Each initiative will be reviewed by a panel of high-level diabetes experts, chaired by Anna Morton, director, NHS Diabetes, and Simon O’Neill, director of care, information and advocacy at Diabetes UK (QiC)

Join Us On Our Journey
NHS Diabetes commissioned Leeds Metropolitan University to undertake a 3-year research project. The aims of the research were to develop a model of care that will deliver the aspirations of the policy document ‘Making Every Young Person with Diabetes Matter’ and improve the care provision for children and young people with type 1 diabetes in England (NHS)

Diabetes: the silent pandemic and its impact on Australia
Data from 2010 show that only about half of Australians with diabetes were achieving adequate control of their blood glucose levels. Poor control of blood glucose means a higher risk of developing diabetes complications – Researched and written by Baker IDI Heart and Diabetes Institute

A pilot test of a tailored mobile and web-based diabetes messaging system for adolescents
The results demonstrate the feasibility of the messaging system, user acceptance and a promising effect on glycaemic control. Integrating this type of messaging system with online educational programming could prove to be beneficial (Journal of Telemedicine and Telecare)

Effect of exenatide on the pharmacokinetics of a combination oral contraceptive
The observed reduction in Cmax is likely of limited importance given the unaltered oral contraceptive bioavailability and trough concentrations; however, for oral medications that are dependent on threshold concentrations for efficacy, such as contraceptives and antibiotics, patients should be advised to take those drugs at least 1 hour before exenatide injection (BMC Clinical Pharmacology)

Oral contraception enhances growth hormone responsiveness to hyper- and hypoglycaemia
Given the known boosting effects of growth hormone on hypoglycaemic hormonal counter-regulation, oral contraceptives may thus be a pharmacological candidate contributing to combat hypoglycaemia unawareness in women with diabetes in the future (Diabetic Medicine)

Platelet Isoprostane Overproduction in Diabetic Patients Treated With Aspirin
These findings suggest that in aspirin-treated diabetic patients, oxidative stress–mediated platelet isoprostane overproduction is associated with enhanced platelet recruitment, an effect that mitigates aspirin-mediated TxA2 inhibition (Diabetes)

Long-Term Efficacy of Dapagliflozin in Patients With Type 2 Diabetes Mellitus Receiving High Doses of Insulin
Dapagliflozin improves glycemic control, stabilizes insulin dosing, and reduces weight without increasing major hypoglycemic episodes in patients with inadequately controlled type 2 diabetes mellitus (Annals of Internal Medicine)

Relationship Between Glycosylated Hemoglobin Assessment and Glucose Therapy Intensification in Patients With Diabetes Hospitalized for Acute Myocardial Infarction
Long-term glucose control is poor in most AMI patients with DM, but only a minority of patients undergo GTI at discharge. Inpatient A1C assessment is strongly associated with intensification of glucose-lowering therapy (Diabetes Care)

Effects of some anti-diabetic and cardioprotective agents on proliferation and apoptosis of human coronary artery endothelial cells
Our results suggest that the anti-diabetic and cardioprotective agents mentioned above have direct and beneficial effects on endothelial cell viability, regeneration and apoptosis. This may add yet another valuable property to their therapeutic effect, increasing their clinical utility in type 2 diabetic patients in whom endothelial dysfunction is a prominent feature that adversely affect their survival (Cardiovascular Diabetology)

Impact of insulin pumps on glycaemic control in a pump-naïve paediatric regional population
In a pump-naïve regional paediatric population, insulin-pump therapy for T1DM was safe and effective, and associated with sustained improvements in HbA1c and lower risk of hypoglycaemia (Journal of Paediatrics and Child Health)

A globally applicable screening model for detecting individuals with undiagnosed diabetes
We identified a globally applicable screening model to detect individuals at high risk of undiagnosed diabetes. The model performed well in most geographical regions, is simple and requires no calculations. This global screening model may be particularly helpful in developing countries with no population based data with which to develop own screening models (Diabetes Research and Clinical Practice)

Diabetes Products Proposals
Proposed changes to funded diabetes management products (PHARMAC, New Zealand)

Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis
In patients with type 2 diabetes who do not achieve the glycaemic targets with metformin alone, DPP-4 inhibitors can lower HbA1c, in a similar way to sulfonylureas or pioglitazone, with neutral effects on body weight. Increased unit cost, which largely exceeds that of the older drugs, and uncertainty about their long term safety, however, should also be considered (BMJ)

Use of an Automated Decision Support Tool Optimizes Clinicians’ Ability to Interpret and Appropriately Respond to Structured Self-Monitoring of Blood Glucose Data
Use of structured SMBG, combined with the DST, the educational DVD, or both, enhances clinicians’ ability to correctly identify significant glycemic patterns and make appropriate therapeutic decisions to address those patterns (Diabetes Care)

A nursing educational intervention helped by One Touch UltraSmart™ improves monitoring and glycated haemoglobin levels in type I diabetic children
Our research showed that the use of One Touch UltraSmart in the context of an educational intervention raised the awareness of the diabetic children and thus helped them to effectively control their disease and to fully understand the necessity of having good dietary and exercise habits (Journal of Clinical Nursing)

Comparison of HbA1c and oral glucose tolerance test for diagnosis of diabetes in patients with coronary artery disease
There is a large discordance between OGTT and HbA1c in terms of detecting latent DM-2 in patients with CAD. Measurement of HbA1c could result in lower propensity of DM-2 diagnosis (Clinical Research in Cardiology)

Generation of functional insulin-producing cells in the gut by Foxo1 ablation
Here, we show that, unexpectedly, somatic ablation of Foxo1 in Neurog3+ enteroendocrine progenitor cells gives rise to gut insulin-positive (Ins+) cells that express markers of mature ß cells and secrete bioactive insulin as well as C-peptide in response to glucose and sulfonylureas (Nature Genetics)

Recreational drug use in type 1 diabetes: an invisible accomplice to poor glycaemic control?
Drug use was associated with worse glycaemic control and higher risk of diabetic ketoacidosis. Medical awareness of common, currently underreported, drug use in young people with T1D is essential. It offers the possibility of helping such patients improve related suboptimal metabolic control (Internal Medicine Journal)

A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes
In the largest study to date, we have established that hsCRP is a clinically valid biomarker for HNF1A-MODY in European populations (Diabetologia)

Diabetes-impaired wound healing and altered macrophage activation: A possible pathophysiologic correlation
It was indicated that changed macrophage activation might contribute to impaired healing in diabetes wounds, and that strategies for reverting this abnormal activation could be useful for enhancing the wound healing process (Wound Repair and Regeneration)

National Diabetes Inpatient Audit 2011

Key findings – Hospital Level Analysis for England – Hospital Level Analysis for Wales – Presentation of Results (Health and Social Care Information Centre)

Variation in the recorded incidence of amputation of the lower limb in England
Variation in amputation incidence occurs across England. Because of the similarity in amputation variation between people with and without diabetes the variation may reflect generic differences in local healthcare delivery, although racial factors may also contribute (Diabetologia)

WHO guidance for the use of HbA1c in the diagnosis of diabetes
Abbreviated Report of a WHO Consultation

Pharmacy effect on adherence to antidiabetic medications
The results suggest significant variation in medication adherence attributable to pharmacy factor, independent of other effects. The underlying reason could be varying level of influence from pharmacies’ efforts to inform or influence patients to take medications in prescribed manners (Medical Care)

Type 2 diabetes managed by diet and lifestyle: HbA1c can identify significant post-prandial hyperglycaemia
Even volunteers with reasonably well-controlled, diet-managed type 2 diabetes spent a large proportion (9/24 hours) of the day with glucose concentrations in excess of 8mmol/L, suggesting that implementation of the IDF guidelines presents a challenge in normal clinical practice (Practical Diabetes)

Persistence of Prolonged C-peptide Production in Type 1 Diabetes as Measured With an Ultrasensitive C-peptide Assay
The ultrasensitive assay revealed that C-peptide production persists for decades after disease onset and remains functionally responsive. These findings suggest that patients with advanced disease, whose ß-cell function was thought to have long ceased, may benefit from interventions to preserve ß-cell function or to prevent complications (Diabetes Care)

Spectrum of congenital anomalies in pregnancies with pregestational diabetes
The increased risk of congenital anomalies in pregnancies with pregestational diabetes is related to specific non-chromosomal congenital anomalies and multiple congenital anomalies and not a general increased risk (Birth Defects Research)

Gestational diabetes and cardiovascular risk factors in the offspring: Results from a cross-sectional study
Gestational diabetes mellitus does not appear to have a relevant effect on cardiovascular disease correlates such as blood pressure or cholesterol levels in children, and the potential effect of gestational diabetes mellitus on body composition seems to be widely explainable by maternal BMI (Diabetic Medicine)

Efficacy of endoluminal interventional therapy in diabetic peripheral arterial occlusive disease: a retrospective trial
With a low risk of morbidity and mortality, the percutaneous revascularization accepted by patients does not affect ultimate necessary surgical revascularization and consequently should be considered as the preferred therapy for chronic lower extremity ischemia. The efficacy and prognosis of interventional therapy in diabetic patients is similar that in non-diabetic patients (Cardiovascular Diabetology)

Applicability of a Combination of Hemoglobin A1c and Fasting Plasma Glucose in Population-based Prediabetes Screening
The enhanced prevalence of prediabetes using HbA1c+FPG compared with FPG+2hPG calls for the need to redefine at a more basic and a more practical level how to apply HbA1c in screening for prediabetes. A redefined HbA1c that incorporates FPG, age, race/ethnicity and BMI may put forward a better way to use HbA1c in population-based and clinical settings (Journal of Diabetes)

Arterial Stiffness Is Increased in Patients With Type 1 Diabetes Without Cardiovascular Disease
Arterial stiffness assessed as aPWV is increased in patients with type 1 diabetes without clinical cardiovascular disease, independently of classical cardiovascular risk factors. In men with type 1 diabetes, low-grade inflammation is independently associated with arterial stiffness (Diabetes Care)

Mechanisms for Insulin Resistance: Common Threads and Missing Links
Evidence presented in this Review suggests that ectopic lipid (diacylglycerols and possibly ceramides) may be at the root cause of liver and muscle insulin resistance and that new therapies aimed at decreasing lipid content in these organs will represent the most efficacious therapeutic targets for the treatment of insulin resistance and its associated comorbidities (Cell)

Meta-analysis of individual patient data in randomised trials of self monitoring of blood glucose in people with non-insulin treated type 2 diabetes
Evidence from this meta-analysis of individual patient data was not convincing for a clinically meaningful effect of clinical management of non-insulin treated type 2 diabetes by self monitoring of blood glucose levels compared with management without self monitoring, although the difference in HbA1c level between groups was statistically significant (BMJ)

The Accuracy Benefit of Multiple Amperometric Glucose Sensors in People With Type 1 Diabetes
Sensor accuracy is significantly improved with the use of multiple sensors compared with the use of a single sensor. These finding isrelevant to the design of an artificial pancreas device (Diabetes Care)

Oral Disposition Index in Obese Youth from Normal to Prediabetes to Diabetes: Relationship to Clamp Disposition Index
The oDI is a simple surrogate estimate of ß-cell function relative to insulin sensitivity that can be applied to obese adolescents with varying glucose tolerance in large-scale epidemiological studies where the applicability of clamp studies is limited due to feasibility, cost, and labor intensiveness (The Journal of Pediatrics)

The Hyperglycemia and Adverse Pregnancy Outcome Study
Both maternal GDM and obesity are independently associated with adverse pregnancy outcomes. Their combination has a greater impact than either one alone (Diabetes Care)

SOD1 suppresses maternal hyperglycemia-increased iNOS expression and consequent nitrosative stress in diabetic embryopathy
We conclude that oxidative stress induces iNOS expression, nitrosative stress, and apoptosis in diabetic embryopathy (American Journal of Obstetrics & Gynecology)

Impact of type 2 diabetes on serial changes in tissue characteristics of coronary plaques: an integrated backscatter intravascular ultrasound analysis
Accelerated plaque progression with an increase in the lipid-rich component of non-culprit plaques was observed in T2DM, despite the use of standard medical treatment. Better glycaemic control ameliorated the worsening of plaque characteristics in T2DM (European Heart Journal – Cardiovascular Imaging)

The management of Type 2 diabetes: A survey of Australian general practitioners
There were significant differences between diabetologists and GPs on the management of diabetes. The survey suggests significant under-dosing by GPs. These findings warrant further investigation (Diabetes Research and Clinical Practice)

Incidence of diabetic retinopathy in people with type 2 diabetes mellitus attending the Diabetic Retinopathy Screening Service for Wales: retrospective analysis
Our analysis supports the extension of the screening interval for people with type 2 diabetes mellitus beyond the currently recommended 12 months, with the possible exception of those with diabetes duration of 10 years or more and on insulin treatment (BMJ)

Emerging Pharmacotherapies for Diabetic Macular Edema
Pharmacotherapies for DME include locally and systemically administered agents. We review several agents that have been studied for the treatment of DME (Experimental Diabetes Research)

Phase III trial tests addition of twice-daily exenatide to insulin glargine in patients with type 2 diabetes
A randomised, double-blind, 30-week, phase III trial (n = 261) found that adding twice-daily exenatide to basal insulin therapy with insulin glargine improved HbA1c levels in patients with sub-optimally controlled type 2 diabetes (NPC Rapid Review)

TAK-875 is the first GPR40 agonist to reach late-stage (Phase 3) clinical development
Phase 2 Data of Takeda’s Investigational GPR40 Agonist, Published in The Lancet, Demonstrated Improved Glycemic Control in Patients with Type 2 Diabetes (Takeda)