The present analysis aimed at assessing the independent association of BMI versus surrogate measures of central adiposity (including both WHtR and ABSI) with death from any cause in the large cohort of well-characterized individuals with type 2 diabetes from the Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicentre Study, which allows accounting for several potential sources of bias (Cardiovascular Diabetology)
Diabetes News
Glycosmedia is dedicated to bringing free, non-promotional, editorially independent news to a global audience about developments in diabetes, and is primarily aimed at health professionals.
Diabetes high impact interventions
An evidence based and quality assured programme that aims to support the person and their family members and carers in developing attitudes, beliefs, knowledge and skills to self-manage diabetes and reduce their chances of deterioration or exacerbation (NHS England)
Longitudinal changes in vitamin D concentrations and the association with type 2 diabetes mellitus: the Tromsø Study
25(OH)D concentrations seem to be affected by disease progression and type 2 diabetes diagnosis (Acta Diabetologica)
The impact of population-level HbA1c screening on reducing diabetes diagnostic delay in middle-aged adults: a UK Biobank analysis
Our population-based study shows that HbA1c screening in adults aged 40–70 years can reduce the time to diabetes diagnosis by a median of 2.2 years compared with routine clinical care (Diabetologia)
Validation of a Risk Prediction Model for Early Chronic Kidney Disease in Patients with Type 2 Diabetes: Data from the German/Austrian DPV Registry
The predictive model achieved moderate discrimination but good calibration in a German/Austrian T2D population suggesting that the model may be relevant for determining CKD risk (Diabetes, Obesity and Metabolism)
Personalized management of dyslipidemias in patients with diabetes—it is time for a new approach (2022)
Overall, patients with diabetes should be carefully examined in terms of CV risk stratification (e.g., taking into consideration TOD, renal function, subclinical atherosclerosis, etc.), to define their lipid goals. We strongly suggest that, for such high-risk patients, LDL-C target should be achieved as early as possible to maximize CVD prevention (Cardiovascular Diabetology)
Oral Insulin (ORMD-0801) in Type 2 Diabetes Mellitus: Dose-Finding 12-Week Randomized Placebo-Controlled Study
Oral insulin (ORMD-0801) induced greater reductions in HbA1c when compared to placebo and was safe and well-tolerated in individuals with uncontrolled T2DM (Institute of Endocrinology, Metabolism & Hypertension )
Care processes in people in remission from type 2 diabetes: A cohort study using the National Diabetes Audit
People coded with remission of type 2 diabetes were less likely to receive diabetes care processes than those without such coding (Diabetic Medicine)
Effects of Intensive Blood Pressure Lowering in Patients with Diabetes: A Pooled Analysis of the STEP and ACCORD-BP Randomized Trials
An intensive SBP lowering target of 110 to <130 mmHg reduces the cardiovascular outcomes compared with a standard SBP lowering target of 130 to <150 mmHg. The findings of this study support the favorable effects of intensive SBP lowering in hypertensive patients with diabetes (Diabetes, Obesity and Metabolism)
An Indirect Comparison of Basal Insulin Plus Once-Weekly Semaglutide and Fully Optimised Basal–Bolus Insulin in Type 2 Diabetes
In T2D uncontrolled by basal insulin, intensification with semaglutide 1.0 mg OW was associated with better glycaemic control, weight loss, and reduced hypoglycaemia versus a basal–bolus regimen, while limiting the treatment burden associated with frequent injections. Clinicians could consider treatment intensification with semaglutide when T2D is uncontrolled by basal insulin, especially when weight management is a priority (Diabetes Therapy)
Application of the PDCA Cycle for Managing Hyperglycemia in Critically Ill Patients
To the best of our knowledge, this is the first report on using the PDCA cycle to manage and control glucose levels in critically ill patients (Diabetes Therapy)
Mounjaro
The European Medicines Agency therefore decided that Mounjaro’s benefits are greater than its risks and it can be authorised for use in the EU
Prognostic value of creatinine-to-cystatin c ratio in patients with type 2 diabetes mellitus: a cohort study
Low muscle mass assessed by Scr/Scys was associated with increased risk of long-term all-cause mortality in diabetic patients (Diabetology & Metabolic Syndrome)
A personalized multi-interventional approach focusing on customized nutrition, progressive fitness, and lifestyle modification resulted in the reduction of HbA1c, fasting blood sugar and weight in type 2 diabetes
The findings indicate that a comprehensive and multi-interventional diabetes care program involving personalized nutrition, fitness, and lifestyle modification such as SDRP, help in significant and sustained improvements in HbA1c level, glycaemic control, and weight loss in adults with type 2 diabetes (BMC Endocrine Disorders)
Screening all older adults aged 40-70 years would find undiagnosed type 2 diabetes cases at least two years earlier
Our study provides the first population-based estimate of the impact of HbA1c-based screening on reducing the time to diabetes diagnosis. In UK Biobank (Diabetologia )
The Platelet-to-Lymphocyte Ratio Predicts Diabetic Retinopathy in Type 2 Diabetes Mellitus
Our findings suggest that PLR may be an independent risk factor for evaluating DR in type 2 diabetes patients (Diabetes, Metabolic Syndrome and Obesity)
Development of a Measure to Assess Attitudes Towards Nasal versus Autoinjector Glucagon Delivery Devices for Treatment of Severe Hypoglycemia
This study supports the validity and reliability of the GDAQ, which successfully conceptualizes attitudes towards devices for administering glucagon among different respondent groups. Use of the GDAQ can help guide the development and testing of new glucagon drug/device combination (Diabetes, Metabolic Syndrome and Obesity)
Sleep and Circadian Rhythm Disturbances in Diabetes: A Narrative Review
We concluded that sleep and circadian rhythm disturbances are closely linked with diabetes. More attention to sleep in regular diabetes care is warranted, while further research is needed on treatment of sleep and circadian rhythm disturbances in the prevention of diabetes and its suboptimal outcomes (Diabetes, Metabolic Syndrome and Obesity)
Attendance at pre-pregnancy care clinics for women with type 1 diabetes: a scoping review
This review highlights the ongoing problem of poor-attendance at PPC and identifies key barriers to be addressed when developing and implementing PPC programs for women with type 1 diabetes (Diabetic Medicine)
Protection against stroke with glucagon-like peptide-1 receptor agonists: a comprehensive review of potential mechanisms
The available evidence remains however insufficient to confirm whether other effects of GLP-1RAs such as direct cardioprotective actions (i.e., effects on atrial electrical remodeling, increased left ventricular ejection fraction, increased myocardial salvage, effects on cardiac oxidative metabolism) and effects on the microvascular function may mechanistically contribute to GLP-1RA-mediated protection against stroke (Cardiovascular Diabetology)
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