Patients with previous cardiovascular metabolic diseases may face a greater risk of developing into the severe condition and the comorbidities can also greatly affect the prognosis of the COVID-19. On the other hand, COVID-19 can, in turn, aggravate the damage to the heart (Clinical Research in Cardiology)
Diabetes News
Category: Pathology
Prognostic Significance of Long-term HbA1c Variability for All-Cause Mortality in the ACCORD Trial
Long-term visit-to-visit HbA1c variability was a strong predictor of all-cause mortality. HbA1c VIM combined with HbA1c mean conferred an increased risk for all-cause mortality in the intensive-therapy group (Diabetes Care)
Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes
Exocrine pancreatic insufficiency is a clinically relevant, frequent but poorly understood disorder in both type 1 and type 2 diabetes (Current Diabetes Reports)
Regression from prediabetes to normal glucose levels is more frequent than progression towards diabetes: The CRONICAS Cohort Study
Regression from pre-diabetes back to euglycemia was much more common than progression to diabetes (Diabetes Research and Clinical Practice)
Iron metabolism and type 2 diabetes mellitus: A meta‐analysis and systematic review
The elevated serum ferritin was one of the risk factors for type 2 diabetes, and soluble transferrin receptor‐to‐ferritin ratio was inversely related to the risk of type 2 diabetes. A systematic review showed that serum transferrin and hepcidin might be directly or indirectly related to the development of diabetes (Journal of Diabetes Investigation)
Analysing the Clinical Features of Pneumomediastinum Associated with Diabetic Ketoacidosis in 79 Cases
Pneumomediastinum associated with DKA is a rare disease, and it has a benign course when an early diagnosis is made and aetiological treatment is administered (Metabolic Syndrome and Obesity: Targets and Therapy )
Progression of Insulin Resistance: A Link between Risk Factors and the Incidence of Diabetes
Change of IR can be used as a surrogate marker of incident diabetes. The progression of IR is an important pathophysiologic link between risk factors and the incidence of diabetes (Diabetes Research and Clinical Practice)
Daytime variability of postprandial glucose tolerance and pancreatic beta‐cell function using 12 hour profiles in persons with type 2 diabetes
There appears to be a shift in diurnal variation in glucose homeostasis and pancreatic beta‐cell function. Subjects had decreased glucose tolerance in response to the first and third meal of the day irrespective of glycaemic control. The variability in glucose tolerance was reflected by both quantitative and qualitative dysfunction of the pancreatic beta‐cell (Diabetic Medicine)
Effects of Gender-Affirming Hormone Therapy on Insulin Sensitivity and Incretin Responses in Transgender People
In this cohort of transgender persons, insulin sensitivity but also post-OGTT incretin responses tend to increase with masculinization and to decrease with feminization (Diabetes Care)
Microvascular complications burden (nephropathy, retinopathy and peripheral polyneuropathy) affects risk of major vascular events and all-cause mortality in type 1 diabetes
The presence and number of microvascular complications should be considered in stratifying overall cardiovascular risk in type 1 diabetes (Cardiovascular Diabetology)
The increased risk of microvascular complications in South Asians with type 1 diabetes is influenced by migration: results from the UK–India multi‐ethnic migration study
In this hypothesis‐generating study, we report that South Asian ethnicity is associated with greater risk of diabetic kidney disease and retinopathy, and lower risk of neuropathy than white European ethnicity (Diabetic Medicine)
Different Analysis of β-Cell Dysfunction as Fasting Glucose Progresses in Obese and Nonobese Newly Diagnosed Type 2 Diabetic Patients
During the progression of baseline FBG, β-cell dysfunction and insulin resistance worsened. As FBG increased, increased BMI had a positive influence on β-cell dysfunction in all FBG groups. The independent factors that correlated to EISI differed with the increasing of baseline FBG (Journal of Diabetes Research)
Characteristics of newly diagnosed adults with type 1 diabetes in the UK and evolution of glycaemic control, body mass index and Charlson comorbidity index over the first 5 years after diagnosis
More intensive support to reach and maintain glycaemic targets soon post-diagnosis, while avoiding weight gain, and prevention and optimal management of comorbidities are warranted (Primary Care Diabetes)
Variability in Glycated Hemoglobin and Risk of Poor Outcomes Among People With Type 2 Diabetes in a Large Primary Care Cohort Study
HbA1c variability was strongly associated with overall mortality and emergency hospitalization and not explained by average HbA1c or hypoglycemic episodes. Only for CAD and IS hospitalizations was no association found, with average HbA1c strongly predictive. Targets should focus on both stability and absolute level of HbA1c (Diabetes Care)
Type 1 Diabetes is Associated with an Increase in Cholesterol Absorption Markers but a Decrease in Cholesterol Synthesis Markers in a Young Adult Population
Plasma markers suggest that cholesterol absorption is increased whereas cholesterol synthesis is decreased in type 1 diabetes. Further studies to address the impact of these changes on the relative efficacy of cholesterol absorption and synthesis inhibitors in subjects with type 1 diabetes are urgently needed (Journal of Clinical Lipidology)
HbA1c level as a risk factor for retinopathy and nephropathy in children and adults with type 1 diabetes: Swedish population based cohort study
Risk of retinopathy and nephropathy did not differ at HbA1c levels <6.5% but increased for severe hypoglycaemia compared with HbA1c levels 6.5-6.9%. The risk for severe complications mainly occurred at HbA1c levels >8.6%, but for milder complications was increased at HbA1c levels >7.0% (BMJ)
Longitudinal evaluation of gastric emptying in type 2 diabetes
In patients with long-term type 2 diabetes, gastric emptying of solids and liquids does not usually become more delayed over time, and abnormally slow gastric emptying of solids may improve (Diabetes Research and Clinical Practice)
Distinct trajectories of HbA1c in newly diagnosed Type 2 diabetes from the DPV registry using a longitudinal group‐based modelling approach
Four subgroups with distinct HbA1c trajectories were determined in newly diagnosed Type 2 diabetes using a group‐based modelling approach. Approximately one‐third of people with newly diagnosed Type 2 diabetes need either better medication adherence or earlier intensification of glucose‐lowering therapy (Diabetic Medicine)
The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort
Comorbidities are common in this population, and high between-patient variability in comorbidity patterns emphasises the need for patient-centred healthcare. Mental health is a growing concern, and there is a need for interventions that target both physical and mental health in this population (BMC Medicine)
Diabetes Mellitus Increases Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-wide Study With Propensity Score Analysis
Type 2 DM is associated with an increased risk of GC among patients in whom HP was eradicated, in particular those with gastric cardia cancer and those with suboptimal DM control (Diabetes Care)
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