Associations were found between genetic liability to type 2 diabetes and an increased risk of a broad range of GDs, highlighting the importance of GD prevention in patients with type 2 diabetes (Diabetes Care)
Diabetes News
Category: Pathology
Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells
We propose that this alternative INS product may play a role in islet autoimmunity and pathology, as well as endocrine or paracrine function or islet development and endocrine destiny, and transdifferentiation between endocrine cells (Diabetologia)
The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes
Our data indicates that the proportion of infiltrated islets and T cell density change dramatically during the course of type 1 diabetes, and these changes can be already observed in double autoantibody-positive individuals (Diabetologia)
Is vitamin B12 deficiency a risk factor for gastroparesis in patients with type 2 diabetes?
Beside the known risk factors of diabetic gastroparesis, vitamin B12 deficiency is an independent predictor of diabetic gastroparesis in patients with T2D (Diabetology & Metabolic Syndrome)
Youth-Onset Type 2 Diabetes: The Epidemiology of an Awakening Epidemic
In this narrative review, we describe the epidemiology (prevalence, incidence, temporal trends, and projections) of type 2 diabetes among children and adolescents (<20 years), focusing on data from the U.S. and reporting global estimates where available. Secondarily, we discuss the clinical course of youth-onset type 2 diabetes, from prediabetes to complications and comorbidities (Diabetes Care)
Serum Cortistatin Level in Type 2 Diabetes Mellitus and Its Relationship with Nonalcoholic Fatty Liver Disease
T2DM was related to decreased serum CST. However, serum CST was correlated with HOMA-β in T2DM patients, while HOMA-IR was not. There was no correlation between CST and NAFLD (International Journal of General Medicine)
Association of COVID-19 Vaccination With Risk for Incident Diabetes After COVID-19 Infection
In this cohort study, COVID-19 infection was associated with increased risk of diabetes, consistent findings of a meta-analysis. Our results suggest that this risk persisted as the Omicron variant became predominant, and the association remained even after accounting for temporal confounders (JAMA)
The association of diabetes status and bone mineral density among US adults: evidence from NHANES 2005–2018
Using NHANES data from 2005 to 2018, we found that patients with abnormal glucose metabolism had increased bone mineral density (BMC Endocrine Disorders)
Are social determinants of health associated with the development of early complications among young adults with type 2 diabetes? A population based study using linked databases
In this multi-ethnic population, non-Western origin was associated with the development of complications, but only in men. Low income was not associated with developing complications. The importance of adequate HbA1c regulation was re-emphasized by this study (Primary Care Diabetes)
Importance of beta cell mass for glycaemic control in people with type 1 diabetes
Our data show higher beta cell mass in people with type 1 diabetes and LGV than in those with HGV, independent of beta cell function (Diabetologia)
Sleep and Circadian Rhythm Disturbances in Diabetes: A Narrative Review
We concluded that sleep and circadian rhythm disturbances are closely linked with diabetes. More attention to sleep in regular diabetes care is warranted, while further research is needed on treatment of sleep and circadian rhythm disturbances in the prevention of diabetes and its suboptimal outcomes (Diabetes, Metabolic Syndrome and Obesity)
Pathophysiology of type 2 diabetes in sub-Saharan Africans
In this review, we summarise the existing knowledge base and data from the only non-pharmacological intervention that explores the pathophysiology of type 2 diabetes in SSA (Diabetologia)
The impact of the COVID-19 pandemic on diabetes services: planning for a global recovery
The COVID-19 pandemic exemplifies the collective effects of politics, economics, social factors, and technology on a pandemic, whereby acute infectious disease and chronic disease meet. Whether at the individual or the community level, acute infections such as COVID-19 and chronic diseases (eg, diabetes) are inexorably related. The response to them needs to be coordinated similarly (The Lancet Diabetes & Endocrinology)
Long-term Outcomes Among Young Adults With Type 2 Diabetes Based on Durability of Glycemic Control: Results From the TODAY Cohort Study
Higher baseline HbA1c concentration and FG variability during year 1 accurately predicted youth with T2D who will experience metabolic decompensation and comorbidities. These values may be useful tools for clinicians when considering early intensification of therapy (Diabetes Care)
Liver, visceral and subcutaneous fat in men and women of South Asian and white European descent: a systematic review and meta-analysis of new and published data
South Asian men and women appear to store more ectopic fat in the liver compared with their white European counterparts with similar BMI levels. Given the emerging understanding of the importance of liver fat in diabetes pathogenesis, these findings help explain the greater diabetes risks in South Asians (Diabetologia)
Association between triglyceride glucose index and atherosclerotic plaques and Burden: findings from a community-based study
Elevated TyG index was associated with increased odds of atherosclerosis in coronary/intra- and extracranial arteries. Compared with HOMA-IR, the TyG index was more strongly associated with intracranial atherosclerosis. Moreover, discordantly high TyG index with HOMA-IR was also important for atherosclerosis identification (Cardiovascular Diabetology)
The effect of neuromuscular electrical stimulation on serum glucose levels in children and adolescents with type-1 diabetes mellitus: a single group clinical trial
It seems that 8 weeks of NMES has beneficial effects on the reduction of FBS and TDD of insulin therefore, it could be suggested as the contributory treatment in management of children and adolescents with type-1 diabetes (BMC Endocrine Disorders)
Comparative effect of metformin versus sulfonylureas with dementia and Parkinson’s disease risk in US patients over 50 with type 2 diabetes mellitus
Metformin users compared with sulfonylurea users were associated with a lower risk of all-cause dementia, AD and VD but not with PD or MCI. Age and renal function modified risk reduction. Our findings support the hypothesis that metformin provides more neuroprotection for dementia than sulfonylureas but not for PD, but further work is required to assess causality (BMJ)
Association Between SGLT2 Inhibitor Treatment and Diabetic Ketoacidosis and Mortality in People With Type 2 Diabetes Admitted to Hospital With COVID-19
We demonstrate a low risk of DKA and high mortality rate in people with T2D admitted to hospital with COVID-19 and limited power, but no evidence, of increased risk of DKA or in-hospital mortality associated with prescription of SGLT2is (Diabetes Care)
The Gut Microbiome Composition Is Altered in Long-standing Type 1 Diabetes and Associates With Glycemic Control and Disease-Related Complications
Our data show that the gut microbiome is altered in people with (long-standing) type 1 diabetes and is associated with glycemic control and diabetes-related complications. As a result of the cross-sectional design, the causality of these relationships remains to be determined (Diabetes Care)
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