Diabetes News

Contrary to our hypothesis, higher adiponectin level was related to higher all-cause mortality. This association was not explained by confounding by other characteristics, including medications or preceding weight loss (Diabetes Care)

Increased inflammation, expression of MMP-9, PTP1B, and aberrant growth factor levels are the main factors associated with failure to heal DFUs. Targeting these factors may prove helpful in the management of DFUs (Diabetes)

The glucagon response to hypoglycemia in adolescents with type 1 diabetes is influenced by the duration of diabetes and can be lost early in the course of the disease (Diabetes Care)

The REasons for Geographic And Racial Differences in Stroke (REGARDS) study – In this population-based study, almost one in four individuals with diabetes reported stroke symptoms, which suggests that screening for stroke symptoms in diabetes may be warranted (Diabetes Care)

Despite improvements in insulin therapy, T1D patients still suffer many reproductive problems that warrant specific diagnoses and therapeutic management. Similar to other states of metabolic stress, T1D represents a challenge to the correct functioning of the reproductive axis (Human Reproduction Update)

Our results suggest that postprandial insulin rather than glucose accounts for postprandial platelet activation in T2DM patients (Diabetes)

Pre-diabetes, defined as impaired glucose tolerance or a combination of impaired fasting glucose and impaired glucose tolerance, may be associated with a higher future risk of stroke, but the relative risks are modest and may reflect underlying confounding (BMJ)

Light touch perception was reduced in longstanding diabetic hand syndromes. Tactile abnormalities that were detected by clinical examination progressed during a two year period and were related to metabolic control and musculoskeletal diagnosis (Diabetes and Its Complications)

These results demonstrate that acute hyperglycemia causes vasodilation and alters endothelial function in adolescents with type 1 diabetes and provide insight into the etiology of macrovascular and microvascular complications of type 1 diabetes (Experimental Diabetes Research)

The quantitative meta-analysis showed that diabetes was a risk factor for incident dementia (including AD, VD and any dementia) and MCI (Journal of Internal Medicine)

A retrospective cohort study in type 2 diabetic patients followed for at least 2years between 2003 and 2009 (Journal of Diabetes and Its Complications)

A structural equation modeling approach suggestive of a common underlying pathophysiology (Metabolism – Clinical and Experimental)

Diabetes differentially affects self-rated overall health and depression by age, with convergence in the oldest age-group with and without diabetes (Diabetes Care)

The study proved that insulin-resistance has an effect on hepatic molecular level and that the topiramate-mediated insulin sensitivity is ensued partly by modulation of hepatic insulin receptor isoforms, activation of tyrosine kinase, induction of GLUT2 and elevation of adiponectin receptors, as well as their ligand, adiponectin, besides its known improving effect on glucose tolerance and lipid homeostasis (PLoS ONE)

Our data indicate that Dectin-1 may be involved in the abnormal immune responses that are observed in patients with T2D (Metabolism – Clinical and Experimental)

More buccodental conditions and carotid intima-media thickness increase appeared in the patients with HbA1c level?>?8.5%, suggesting onset of atherosclerosis. The correlation between buccodental status and HbA1c values may indicate the connection between inflammatory states of atherosclerosis and type 1 diabetes (Pediatric Diabetes)

This prospective study found strong associations of incident diabetes with baseline levels of three IGFBPs and free IGF-I, consistent with hypotheses that the IGF axis might influence diabetes risk (Diabetes)