Diabetes News

In adolescents with type 1 diabetes, poor glycemic control is associated with abnormalities in HDL subclasses distribution and HDL lipid composition, however, in spite of these HDL changes, the ability of HDL to promote cholesterol efflux remains comparable to that of healthy subjects (Pediatric Diabetes)

Children with type 1 diabetes had significantly different WM structure (as measured by A Diffusion Tenso) when compared with controls. In addition, WM structural differences (as measured by RD) were significantly correlated with their HbA1c values (Diabetes Care)

The results suggest a distinct, virus-strain-specific, gene expression pattern leading to pancreatic islet destruction and pro-inflammatory effects after enterovirus infection. However, neither viral replication nor cytotoxic cytokine production alone are sufficient to induce necrotic cell death. More likely the combined effect of these and possibly cellular energy depletion lie behind the enterovirus-induced necrosis of islets (Diabetologia)

Individuals with lower serum 25(OH)D concentrations had higher risk of insulin-requiring diabetes than those with higher concentrations (Diabetologia)

Blood pressure below 130/80 mm Hg was not associated with reduced risk of all cause mortality in patients with newly diagnosed diabetes, with or without known cardiovascular disease. Low blood pressure, particularly below 110/75 mm Hg, was associated with an increased risk for poor outcomes (British Medical Journal)

Insulin resistance is a prominent feature of lean patients with type 1 diabetes mellitus, despite long term and stable treatment with CSII. Insulin resistance in type 1 diabetes involves both lipolysis, hepatic and peripheral glucose metabolism (Diabetes/Metabolism Research and Reviews)

American adults of a normal weight with new-onset diabetes die at a higher rate than overweight/obese adults with the same disease, according to a new study by (Northwestern Medicine)

Factors associated with pancreatic exocrine failure differ in patients with Type 1 diabetes compared with patients with type 2 diabetes. In patients with Type 2 diabetes, association of decreased pancreatic exocrine function with BMI and vascular disease suggests a role of pancreatic arteriopathy (Diabetic Medicine)

The presence of insulin resistance is associated with poorer responses to hepatitis C therapy in mono-infected patients. However, it is unclear if the progression of insulin resistance is associated with the progression of liver fibrosis in co-infected patients (Aidsmap)

Periodontitis is more prevalent among persons with DM, the poor, and the elderly. In fact, periodontal disease has been called the sixth complication of DM (JAAPA)

Contrary to our hypothesis, higher adiponectin level was related to higher all-cause mortality. This association was not explained by confounding by other characteristics, including medications or preceding weight loss (Diabetes Care)

Increased inflammation, expression of MMP-9, PTP1B, and aberrant growth factor levels are the main factors associated with failure to heal DFUs. Targeting these factors may prove helpful in the management of DFUs (Diabetes)

The glucagon response to hypoglycemia in adolescents with type 1 diabetes is influenced by the duration of diabetes and can be lost early in the course of the disease (Diabetes Care)

The REasons for Geographic And Racial Differences in Stroke (REGARDS) study – In this population-based study, almost one in four individuals with diabetes reported stroke symptoms, which suggests that screening for stroke symptoms in diabetes may be warranted (Diabetes Care)

Despite improvements in insulin therapy, T1D patients still suffer many reproductive problems that warrant specific diagnoses and therapeutic management. Similar to other states of metabolic stress, T1D represents a challenge to the correct functioning of the reproductive axis (Human Reproduction Update)

Our results suggest that postprandial insulin rather than glucose accounts for postprandial platelet activation in T2DM patients (Diabetes)

Pre-diabetes, defined as impaired glucose tolerance or a combination of impaired fasting glucose and impaired glucose tolerance, may be associated with a higher future risk of stroke, but the relative risks are modest and may reflect underlying confounding (BMJ)

Light touch perception was reduced in longstanding diabetic hand syndromes. Tactile abnormalities that were detected by clinical examination progressed during a two year period and were related to metabolic control and musculoskeletal diagnosis (Diabetes and Its Complications)

These results demonstrate that acute hyperglycemia causes vasodilation and alters endothelial function in adolescents with type 1 diabetes and provide insight into the etiology of macrovascular and microvascular complications of type 1 diabetes (Experimental Diabetes Research)

The quantitative meta-analysis showed that diabetes was a risk factor for incident dementia (including AD, VD and any dementia) and MCI (Journal of Internal Medicine)