In individuals with normal glucose tolerance, β-cell function and insulin sensitivity gradually decrease with a deterioration in the lipid profile. Not only fasting TG but also postprandial TG concentrations are independent risk factors for impaired β-cell function and insulin resistance (Journal of Diabetes Investigation)
Diabetes News
Category: Screening
Discovery of a Biomarker Signature That Reveals a Molecular Mechanism Underlying Diabetic Kidney Disease via Organ Cross Talk
AI-assisted discovery of the biomarker signature reveals a potential molecular mechanism underlying the complex interorgan communication occurring during DKD pathogenesis (Diabetes Care)
Screening Strategy for Islet Autoantibodies in Diabetes Patients of Different Ages
In patients stratified according to the cutoff age of 35 years, the optimal detection sequence should be GADA, IA-2A, and ZnT8A in younger patients and GADA, ZnT8A, and IA-2A in older patients, so as to reduce the screening cost while improving the detection rate. Particularly, the ZnT8A test is recommended in older patients to avoid a missed LAD diagnosis (Diabetes Technology and Therapeutics)
Ambulatory Glucose Profile (AGP) Report in Daily Care of Patients with Diabetes: Practical Tips and Recommendations
Report and illustrate the essential components of an AGP review in a series of hypothetical, real-world, patient-centred case studies (Diabetes Therapy)
A systematic review of the prevalence, risk factors and screening tools for autonomic and diabetic peripheral neuropathy in children, adolescents and young adults with type 1 diabetes
Prevalence of neuropathy in youth with type 1 diabetes varies depending on different screening methods and characteristics of the study populations. However, the assessed studies confirmed a relatively high prevalence of subclinical neuropathy, reiterating the importance of early identification of risk factors to prevent this complication (Acta Diabetologica)
Improvements in Awareness and Testing Have Led to a Threefold Increase Over 10 Years in the Identification of Monogenic Diabetes in the U.K.
Since 2009, referral rates and case diagnosis have increased threefold. This is likely to be the consequence of tNGS, GDN education, and use of the MODY calculator (Diabetes Care)
Characterising the age-dependent effects of risk factors on type 1 diabetes progression
Analysing the age-varying effect of disease predictors improves understanding and prediction of type 1 diabetes disease progression, and should be leveraged to refine prediction models and guide mechanistic studies (Diabetologia)
Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study
Strikingly different metabolic signatures were associated with subclinical coronary atherosclerosis in AA and EA DHS participants (Cardiovascular Diabetology)
Association of glycated hemoglobin A1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium
Elevated HbA1c levels were associated with cardiovascular disease incidence and overall mortality in participants without diabetes underlining the importance of HbA1c levels in the overall population (Cardiovascular Diabetology)
Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention
There is a potential to identify both T2D and T1D at stages well before the onset of currently recognized clinical disease (Diabetes)
Real-world screening for diabetes in early pregnancy: Improved screening uptake using universal glycated haemoglobin
Universal early pregnancy HbA1c appears feasible as an early screening test for women at risk of hyperglycaemia in pregnancy and would expedite and increase screening in Aboriginal women compared to an early OGTT (Primary Care Diabetes)
Prediction model for the onset risk of impaired fasting glucose: a 10-year longitudinal retrospective cohort health check-up study
The prediction model for the onset risk of IFG had good predictive ability in the health check-up cohort (BMC Endocrine Disorders)
The importance of addressing multiple risk markers in type 2 diabetes: results from the LEADER and SUSTAIN 6 trials
In persons with type 2 diabetes, improvements in ≥2 risk markers conferred cardiovascular risk reduction versus none or 1 improved risk marker. The nephropathy risk decreased with improvement in more risk markers. These findings stress the importance of multifactorial interventions targeting all risk markers (Diabetes, Obesity and Metabolism)
Epidemiological Research Advances in Vascular Calcification in Diabetes
Because basic research on the clinical transformation of vascular calcification has yet to be conducted, this study systematically expounds on the risk factors for vascular calcification, vascular bed differences, sex differences, ethnic differences, diagnosis, severity assessments, and treatments to facilitate the identification of a new entry point for basic research and subsequent clinical transformation regarding vascular calcification and corresponding clinical evaluation strategies (Journal of Diabetes Research)
Chronic Kidney Disease Testing Among Primary Care Patients With Type 2 Diabetes Across 24 U.S. Health Care Organizations
While eGFR testing rates are uniformly high among people with type 2 diabetes, testing rates for uACR are suboptimal and highly variable across and within the organizations examined. Guideline-recommended uACR testing should increase detection of CKD (Diabetes Care)
WBC count predicts heart failure in diabetes and coronary artery disease patients: a retrospective cohort study
A higher WBC count is a predictor of hospitalization for HF, all-cause death and AMI but not for stroke in patients with concurrent Type 2 diabetes mellitus and established CAD (ESC Heart Failure)
Cardiovascular risk prediction in type 2 diabetes before and after widespread screening: a derivation and validation study
International treatment guidelines still consider most people with diabetes to be at high cardiovascular risk; however, we show that recent widespread diabetes screening has radically changed the cardiovascular risk profile of people with diabetes in New Zealand (The Lancet)
Diagnostic value of combined islet antigen-reactive T cells and autoantibodies assays for type 1 diabetes mellitus
Enzyme-linked immunospot assays in combination with Abs detection could improve the diagnostic sensitivity of autoimmune diabetes (Journal of Diabetes Investigation)
Usefulness of skin advanced glycation end products to predict coronary artery calcium score in patients with type 2 diabetes
Our finding suggests that SAF could be useful in selecting T2D patients in whom the screening for CAD by means of CACs assessment would be more cost-effective (Acta Diabetologica)
Prediabetes and risk of heart failure: the link grows stronger
This study provides important evidence that the risk of heart failure is increased in people with a fasting plasma glucose concentration as low as 100 mg/dL, supporting the definition of prediabetes according to the American Diabetes Association guideline (Cardiovascular Diabetology)
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