Strikingly different metabolic signatures were associated with subclinical coronary atherosclerosis in AA and EA DHS participants (Cardiovascular Diabetology)
Diabetes News
Category: Screening
Association of glycated hemoglobin A1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium
Elevated HbA1c levels were associated with cardiovascular disease incidence and overall mortality in participants without diabetes underlining the importance of HbA1c levels in the overall population (Cardiovascular Diabetology)
Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention
There is a potential to identify both T2D and T1D at stages well before the onset of currently recognized clinical disease (Diabetes)
Real-world screening for diabetes in early pregnancy: Improved screening uptake using universal glycated haemoglobin
Universal early pregnancy HbA1c appears feasible as an early screening test for women at risk of hyperglycaemia in pregnancy and would expedite and increase screening in Aboriginal women compared to an early OGTT (Primary Care Diabetes)
Prediction model for the onset risk of impaired fasting glucose: a 10-year longitudinal retrospective cohort health check-up study
The prediction model for the onset risk of IFG had good predictive ability in the health check-up cohort (BMC Endocrine Disorders)
The importance of addressing multiple risk markers in type 2 diabetes: results from the LEADER and SUSTAIN 6 trials
In persons with type 2 diabetes, improvements in ≥2 risk markers conferred cardiovascular risk reduction versus none or 1 improved risk marker. The nephropathy risk decreased with improvement in more risk markers. These findings stress the importance of multifactorial interventions targeting all risk markers (Diabetes, Obesity and Metabolism)
Epidemiological Research Advances in Vascular Calcification in Diabetes
Because basic research on the clinical transformation of vascular calcification has yet to be conducted, this study systematically expounds on the risk factors for vascular calcification, vascular bed differences, sex differences, ethnic differences, diagnosis, severity assessments, and treatments to facilitate the identification of a new entry point for basic research and subsequent clinical transformation regarding vascular calcification and corresponding clinical evaluation strategies (Journal of Diabetes Research)
Chronic Kidney Disease Testing Among Primary Care Patients With Type 2 Diabetes Across 24 U.S. Health Care Organizations
While eGFR testing rates are uniformly high among people with type 2 diabetes, testing rates for uACR are suboptimal and highly variable across and within the organizations examined. Guideline-recommended uACR testing should increase detection of CKD (Diabetes Care)
WBC count predicts heart failure in diabetes and coronary artery disease patients: a retrospective cohort study
A higher WBC count is a predictor of hospitalization for HF, all-cause death and AMI but not for stroke in patients with concurrent Type 2 diabetes mellitus and established CAD (ESC Heart Failure)
Cardiovascular risk prediction in type 2 diabetes before and after widespread screening: a derivation and validation study
International treatment guidelines still consider most people with diabetes to be at high cardiovascular risk; however, we show that recent widespread diabetes screening has radically changed the cardiovascular risk profile of people with diabetes in New Zealand (The Lancet)
Diagnostic value of combined islet antigen-reactive T cells and autoantibodies assays for type 1 diabetes mellitus
Enzyme-linked immunospot assays in combination with Abs detection could improve the diagnostic sensitivity of autoimmune diabetes (Journal of Diabetes Investigation)
Usefulness of skin advanced glycation end products to predict coronary artery calcium score in patients with type 2 diabetes
Our finding suggests that SAF could be useful in selecting T2D patients in whom the screening for CAD by means of CACs assessment would be more cost-effective (Acta Diabetologica)
Prediabetes and risk of heart failure: the link grows stronger
This study provides important evidence that the risk of heart failure is increased in people with a fasting plasma glucose concentration as low as 100 mg/dL, supporting the definition of prediabetes according to the American Diabetes Association guideline (Cardiovascular Diabetology)
Associated Autoimmunity in Type 1 Diabetes and Latent Autoimmune Diabetes of Adults: The Role of Glutamic-Acid Decarboxylase Autoantibodies
AADs were present in 58.13% of patients. Patients with LADA were more prone to a generalized autoimmune disorder than those with T1D. AADs development was significantly associated with female sex, older age and positive GADA, which proved an independent marker of associated autoimmunity (Diabetes Research and Clinical Practice)
Importance of Early Screening and Diagnosis of Chronic Kidney Disease in Patients with Type 2 Diabetes
Medications shown to slow progression of CKD include renin–angiotensin system inhibitors, sodium–glucose cotransporter-2 inhibitors, glucagon-like peptide 1 receptor agonists and, more recently, non-steroidal mineralocorticoid receptor antagonists (Diabetes Therapy)
Prospective evaluation of an artificial intelligence-enabled algorithm for automated diabetic retinopathy screening of 30 000 patients
The algorithm demonstrated safe levels of sensitivity for high-risk retinopathy in a real-world screening service, with specificity that could halve the workload for human graders (British Journal of Ophthalmology)
Examining if the relationship between BMI and incident type 2 diabetes among middle–older aged adults varies by race/ethnicity
This study supports including BMI and presence of type 2 diabetes risk factors as action points for clinicians to prioritize which adults aged ≥ 45 years should be screened. The application of race/ethnicity‐specific BMI thresholds may reduce the disparity of undiagnosed type 2 diabetes observed in minority groups (Diabetic Medicine)
Incidence of sight threatening diabetic retinopathy in an established urban screening programme: an 11‐year cohort study
In an established screening programme with a stable population screen positive rates show a consistent fall over time to a low level. Of those who are screen positive, fewer than 50% are screen positive for DR. Most are due to sight threatening maculopathy (Diabetic Medicine)
The contribution of the English NHS Diabetic Eye Screening Programme to reductions in diabetes-related blindness, comparisons within Europe, and future challenges
Current plans for NHS DESP include extension of screening intervals in low-risk groups and the introduction of optical coherence tomography as a second line of screening for those with screen positive maculopathy with two dimensional markers. Future challenges include the introduction of automated analysis for grading and new camera technologies (Acta Diabetologica)
Identifying patients at increased risk of hypoglycaemia in primary care: Development of a machine learning‐based screening tool
Using demographic and medication data, a model for identifying patients at increased risk of hypoglycaemia was developed using machine learning. This model can be used as a tool in primary care to screen for patients with T2D who may need additional attention to prevent or reduce hypoglycaemic events (Diabetes/Metabolism Research and Reviews)
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