Circulating ANGPTL2 levels are an independent risk factor for DFUs. This suggests that ANGPTL2 may play important roles in the development of DFUs, a possibility that needs to investigated in prospective studies (BMC Endocrine Disorders)
Diabetes News
Category: Screening
Adaptation of Insulin Clearance to Metabolic Demand is a Key Determinant of Glucose Tolerance
The development of IR in obese subjects is associated with decline in MCRI that represents a compensatory response to maintain normal glucose tolerance but is impaired in T2DM individuals (Diabetes)
Associations of cardiac stress biomarkers with incident type 2 diabetes and changes in glucose metabolism: KORA F4/FF4 study
High plasma concentrations of MR-proANP contributed to a lower risk of incident T2D, whereas high plasma concentrations of copeptin were associated with an increased risk of incident prediabetes/T2D (Cardiovascular Diabetology)
Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects
Soluble EGFR, a hepatokine, is correlated with insulin resistance in the liver, while adipsin, an adipokine, is associated with adipose insulin resistance (Diabetology & Metabolic Syndrome)
Triglyceride-glucose index predicts independently type 2 diabetes mellitus risk: A systematic review and meta-analysis of cohort studies
TyG index has a positive and significant association with T2D risk, suggesting that the TyG index may become an applicable tool to identify subjects with T2D risk (Primary Care Diabetes)
Autoantibodies against zinc transporter 8 further stratify the autoantibody-defined risk for type 1 diabetes in a general population of schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes
Zinc transporter 8 autoantibodies are useful markers for prediction of type 1 diabetes in a general population, further stratifying the risk of progression in autoantibody-positive children (Diabetic Medicine)
Examining if the relationship between BMI and incident type 2 diabetes among middle–older aged adults varies by race/ethnicity: evidence from the Multi‐Ethnic Study of Atherosclerosis (MESA)
This study supports including BMI and presence of type 2 diabetes risk factors as action points for clinicians to prioritize which adults aged ≥ 45 years should be screened (Diabetic Medicine)
Risk factors for hospitalization in youth with type 1 diabetes: Development and validation of a multivariable prediction model
Our multivariable prediction model identified patients at increased risk of admission in the 12 months following assessment (Pediatric Diabetes)
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes
Our study provides robust histological evidence that a clinical diagnostic model, combining clinical features and biomarkers, could improve diabetes classification. Our study also provides reassurance that a C‐peptide‐based definition of type 1 diabetes is an appropriate surrogate outcome that can be used in large clinical studies where histological definition is impossible (Diabetic Medicine)
Update on clinical screening of maturity-onset diabetes of the young (MODY)
The selection of diabetic patients for genetic testing is an ongoing challenge. Metabolic profiling, diabetes onset age, pancreatic antibodies, and C-peptide seem to be useful tools to better select patients for genetic testing (Diabetology & Metabolic Syndrome)
Population-based screen-detected type 2 diabetes mellitus is associated with less need for insulin therapy after 10 years
Population-based screen-detected type 2 diabetes is associated with less need for insulin after 10 years compared with people diagnosed during care-as-usual. Glycemic control was better after screen detection but on average good in all groups (BMJ)
Eye care providers’ emerging roles in early detection of diabetes and management of diabetic changes to the ocular surface: a review
Recent ophthalmic research has identified multiple subclinical and clinical changes that occur in the anterior segment of the eye with metabolic disease (BMJ)
Plasma Lipidome and Prediction of Type 2 Diabetes in the Population-Based Malmö Diet and Cancer Cohort
A lifestyle-related lipidomic profile strongly predicts T2DM development beyond current risk factors. Further studies are warranted to test if lifestyle interventions modifying this lipidomic profile can prevent T2DM (Diabetes Care)
Predictive models for diabetes mellitus using machine learning techniques
The ability of our model to predict patients with Diabetes using some commonly used lab results is high with satisfactory sensitivity. These models can be built into an online computer program to help physicians in predicting patients with future occurrence of diabetes and providing necessary preventive interventions (BMC Endocrine Disorders)
The Role of the Autonomic Nervous System on Cardiac Rhythm during the Evolution of Diabetes Mellitus Using Heart Rate Variability as a Biomarker
It is possible to avoid the consequences of DM identifying alterations in Sinus Atrial Node previous to its symptomatic appearance. This could be used as an early diagnosis indicator (Journal of Diabetes Research)
Changes in Screening Practices for Prediabetes and Diabetes Since the Recommendation for Hemoglobin A1c Testing
As we observed in 2004, rates of screening are high. HbA1c is still used less frequently than glucose for screening but is more likely to result in a clinical diagnosis. Evidence to support guidelines to define the role of random glucose screening, including definition of appropriate cut points and follow-up, is needed (Diabetes Care)
Evaluation of the Finnish Diabetes Risk Score as a screening tool for undiagnosed type 2 diabetes and dysglycaemia among early middle-aged adults in a large-scale European cohort
FINDRISC can be applied for screening primarily undiagnosed T2DM but also dysglycaemia among vulnerable groups across Europe, considering the use of different cut-offs for each subpopulation (Diabetes Research and Clinical Practice)
Preventing misdiagnosis of diabetes in the elderly: age-dependent HbA1c reference intervals derived from two population-based study cohorts
The present study confirmed the previously observed increase of HbA1c with increasing age in non-diabetic individuals. As a consequence age-dependent reference values for HbA1c were derived from two large and well defined reference populations. Implementation of them into daily practice may improve patient care and diagnosis of diabetes and reduce the risk of misdiagnosis and subsequent overtreatment of diabetes in elderly patients (BMC Endocrine Disorders)
Nomogram for predicting diabetes mellitus after the first attack of acute pancreatitis
The nomogram is a potentially clinically useful tool for predicting new-onset diabetes, which is currently clinically unprecedented. This finding is not confined to the patients with severe AP but is also for patients who have recovered from mild AP. The nomogram must to be validated externally (European Journal of Gastroenterology & Hepatology)
Prevalence of diabetes and its effects on stroke outcomes: A meta‐analysis and literature review
Approximately one‐third of all stroke patients have diabetes. Uniform methods to screen for diabetes after stroke are required to identify individuals with diabetes to design interventions aimed at reducing poor outcomes in this high‐risk population (Journal of Diabetes Investigation)
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