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Diabetes News

Category: Screening


Oral Fat Tolerance Testing Identifies Abnormal Pancreatic β-Cell Function and Insulin Resistance in Individuals with Normal Glucose Tolerance

June 9th 2022

In individuals with normal glucose tolerance, β-cell function and insulin sensitivity gradually decrease with a deterioration in the lipid profile. Not only fasting TG but also postprandial TG concentrations are independent risk factors for impaired β-cell function and insulin resistance (Journal of Diabetes Investigation)

Categories: News, Screening
Tags: Insulin resistance, lipids, β-cell

Categories: Screening
Tags: Insulin resistance, lipids, β-cell

Discovery of a Biomarker Signature That Reveals a Molecular Mechanism Underlying Diabetic Kidney Disease via Organ Cross Talk

June 3rd 2022

AI-assisted discovery of the biomarker signature reveals a potential molecular mechanism underlying the complex interorgan communication occurring during DKD pathogenesis (Diabetes Care)

Categories: News, Screening
Tags: biomarker, CKD

Categories: Screening
Tags: biomarker, CKD

Screening Strategy for Islet Autoantibodies in Diabetes Patients of Different Ages

March 15th 2022

In patients stratified according to the cutoff age of 35 years, the optimal detection sequence should be GADA, IA-2A, and ZnT8A in younger patients and GADA, ZnT8A, and IA-2A in older patients, so as to reduce the screening cost while improving the detection rate. Particularly, the ZnT8A test is recommended in older patients to avoid a missed LAD diagnosis (Diabetes Technology and Therapeutics)

Categories: News, Screening
Tags: autoantibodies

Categories: Screening
Tags: autoantibodies

Ambulatory Glucose Profile (AGP) Report in Daily Care of Patients with Diabetes: Practical Tips and Recommendations

March 13th 2022

Report and illustrate the essential components of an AGP review in a series of hypothetical, real-world, patient-centred case studies (Diabetes Therapy)

Categories: Monitoring, News, Screening

Categories: Monitoring, Screening

A systematic review of the prevalence, risk factors and screening tools for autonomic and diabetic peripheral neuropathy in children, adolescents and young adults with type 1 diabetes

January 30th 2022

Prevalence of neuropathy in youth with type 1 diabetes varies depending on different screening methods and characteristics of the study populations. However, the assessed studies confirmed a relatively high prevalence of subclinical neuropathy, reiterating the importance of early identification of risk factors to prevent this complication (Acta Diabetologica)

Categories: Neuropathy, News, Paediatrics, Screening
Tags: Type 1 Diabetes

Categories: Neuropathy, Paediatrics, Screening
Tags: Type 1 Diabetes

Improvements in Awareness and Testing Have Led to a Threefold Increase Over 10 Years in the Identification of Monogenic Diabetes in the U.K.

January 25th 2022

Since 2009, referral rates and case diagnosis have increased threefold. This is likely to be the consequence of tNGS, GDN education, and use of the MODY calculator (Diabetes Care)

Categories: Genetics, News, Screening
Tags: sequencing

Categories: Genetics, Screening
Tags: sequencing

Characterising the age-dependent effects of risk factors on type 1 diabetes progression

January 19th 2022

Analysing the age-varying effect of disease predictors improves understanding and prediction of type 1 diabetes disease progression, and should be leveraged to refine prediction models and guide mechanistic studies (Diabetologia)

Categories: Monitoring, News, Screening
Tags: Type 1 Diabetes

Categories: Monitoring, Screening
Tags: Type 1 Diabetes

Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study

December 8th 2021

Strikingly different metabolic signatures were associated with subclinical coronary atherosclerosis in AA and EA DHS participants (Cardiovascular Diabetology)

Categories: Cardiovascular, News, Screening
Tags: atherosclerosis, metabolomic

Categories: Cardiovascular, Screening
Tags: atherosclerosis, metabolomic

Association of glycated hemoglobin A1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium

November 17th 2021

Elevated HbA1c levels were associated with cardiovascular disease incidence and overall mortality in participants without diabetes underlining the importance of HbA1c levels in the overall population (Cardiovascular Diabetology)

Categories: News, Screening
Tags: HbA1c

Categories: Screening
Tags: HbA1c

Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention

October 28th 2021

There is a potential to identify both T2D and T1D at stages well before the onset of currently recognized clinical disease (Diabetes)

Categories: Genetics, News, Screening
Tags: Type 1 Diabetes, Type 2 Diabetes, β-cell

Categories: Genetics, Screening
Tags: Type 1 Diabetes, Type 2 Diabetes, β-cell

Real-world screening for diabetes in early pregnancy: Improved screening uptake using universal glycated haemoglobin

October 24th 2021

Universal early pregnancy HbA1c appears feasible as an early screening test for women at risk of hyperglycaemia in pregnancy and would expedite and increase screening in Aboriginal women compared to an early OGTT (Primary Care Diabetes)

Categories: Gestational, News, Screening
Tags: HbA1c

Categories: Gestational, Screening
Tags: HbA1c

Prediction model for the onset risk of impaired fasting glucose: a 10-year longitudinal retrospective cohort health check-up study

October 24th 2021

The prediction model for the onset risk of IFG had good predictive ability in the health check-up cohort (BMC Endocrine Disorders)

Categories: Gestational, News, Screening
Tags: prediction

Categories: Gestational, Screening
Tags: prediction

The importance of addressing multiple risk markers in type 2 diabetes: results from the LEADER and SUSTAIN 6 trials

October 22nd 2021

In persons with type 2 diabetes, improvements in ≥2 risk markers conferred cardiovascular risk reduction versus none or 1 improved risk marker. The nephropathy risk decreased with improvement in more risk markers. These findings stress the importance of multifactorial interventions targeting all risk markers (Diabetes, Obesity and Metabolism)

Categories: News, Screening
Tags: LEADER, SUSTAIN, Type 2 Diabetes

Categories: Screening
Tags: LEADER, SUSTAIN, Type 2 Diabetes

Epidemiological Research Advances in Vascular Calcification in Diabetes

October 1st 2021

Because basic research on the clinical transformation of vascular calcification has yet to be conducted, this study systematically expounds on the risk factors for vascular calcification, vascular bed differences, sex differences, ethnic differences, diagnosis, severity assessments, and treatments to facilitate the identification of a new entry point for basic research and subsequent clinical transformation regarding vascular calcification and corresponding clinical evaluation strategies (Journal of Diabetes Research)

Categories: Cardiovascular, Monitoring, News, Screening
Tags: calcification

Categories: Cardiovascular, Monitoring, Screening
Tags: calcification

Chronic Kidney Disease Testing Among Primary Care Patients With Type 2 Diabetes Across 24 U.S. Health Care Organizations

September 1st 2021

While eGFR testing rates are uniformly high among people with type 2 diabetes, testing rates for uACR are suboptimal and highly variable across and within the organizations examined. Guideline-recommended uACR testing should increase detection of CKD (Diabetes Care)

Categories: News, Screening
Tags: CKD, Type 2 Diabetes

Categories: Screening
Tags: CKD, Type 2 Diabetes

WBC count predicts heart failure in diabetes and coronary artery disease patients: a retrospective cohort study

July 20th 2021

A higher WBC count is a predictor of hospitalization for HF, all-cause death and AMI but not for stroke in patients with concurrent Type 2 diabetes mellitus and established CAD (ESC Heart Failure)

Categories: Cardiovascular, News, Screening
Tags: Type 2 Diabetes, WBC

Categories: Cardiovascular, Screening
Tags: Type 2 Diabetes, WBC

Cardiovascular risk prediction in type 2 diabetes before and after widespread screening: a derivation and validation study

June 16th 2021

International treatment guidelines still consider most people with diabetes to be at high cardiovascular risk; however, we show that recent widespread diabetes screening has radically changed the cardiovascular risk profile of people with diabetes in New Zealand (The Lancet)

Categories: News, Screening
Tags: Type 2 Diabetes

Categories: Screening
Tags: Type 2 Diabetes

Diagnostic value of combined islet antigen-reactive T cells and autoantibodies assays for type 1 diabetes mellitus

June 9th 2021

Enzyme-linked immunospot assays in combination with Abs detection could improve the diagnostic sensitivity of autoimmune diabetes (Journal of Diabetes Investigation)

Categories: News, Screening
Tags: antigen-reactive T cells, autoantibodies, Type 1 Diabetes

Categories: Screening
Tags: antigen-reactive T cells, autoantibodies, Type 1 Diabetes

Usefulness of skin advanced glycation end products to predict coronary artery calcium score in patients with type 2 diabetes

May 25th 2021

Our finding suggests that SAF could be useful in selecting T2D patients in whom the screening for CAD by means of CACs assessment would be more cost-effective (Acta Diabetologica)

Categories: Cardiovascular, News, Screening
Tags: artery calcium, glycation, Type 2 Diabetes

Categories: Cardiovascular, Screening
Tags: artery calcium, glycation, Type 2 Diabetes

Prediabetes and risk of heart failure: the link grows stronger

May 25th 2021

This study provides important evidence that the risk of heart failure is increased in people with a fasting plasma glucose concentration as low as 100 mg/dL, supporting the definition of prediabetes according to the American Diabetes Association guideline (Cardiovascular Diabetology)

Categories: Cardiovascular, News, Screening
Tags: prediabetes

Categories: Cardiovascular, Screening
Tags: prediabetes
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