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Diabetes News

Category: Transplantation


Post transplant related diabetes – new guideline launch

August 11th 2020

Their latest guidance on the detection, management and prevention of Post-Transplant Diabetes Mellitus have just been launched (ABCD)

Categories: News, Transplantation
Tags: ABCD

Categories: Transplantation
Tags: ABCD

Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche

May 13th 2020

We found PDX1+/ALK3+/CAII− progenitor-like cells in the MPDs of types 1 and 2 diabetes donors, regardless of the duration of the disease. Our findings open the door to the pharmacological activation of progenitor cells in situ (PNAS)

Categories: News, Transplantation
Tags: stem cells

Categories: Transplantation
Tags: stem cells

Ten-Year Outcome of Islet Alone or Islet After Kidney Transplantation in Type 1 Diabetes: A Prospective Parallel-Arm Cohort Study

October 16th 2019

Islet transplantation with the Edmonton protocol can provide 10-year markedly improved metabolic control without SHEs in three-quarters of patients with type 1 diabetes, kidney transplanted or not (Diabetes Care)

Categories: News, Transplantation
Tags: Islet cell transplantation, Type 1 Diabetes

Categories: Transplantation
Tags: Islet cell transplantation, Type 1 Diabetes

Biomarkers in Islet Cell Transplantation for Type 1 Diabetes

September 5th 2018

Recent advances in identifying accurate beta cell-specific biomarkers such as differentially methylated insulin cell-free DNA and circulating miRNA-375 may help predict clinical outcomes (Current Diabetes Reports)

Categories: News, Transplantation
Tags: beta cell, biomarkers, Type 1 Diabetes

Categories: Transplantation
Tags: beta cell, biomarkers, Type 1 Diabetes

Improved Insulin Sensitivity Appears to Remain for a Mean of Four Years Following Islet Cell Transplant for Type 1 Diabetes

December 12th 2017

IS measured by SIis was improved several years following transplant, while IS measured by HOMA-IR did not worsen. Higher exenatide dose, more islets transplanted, and diet and exercise (lowering leptin and RANKL) may improve IS, which may enhance glycemic control and lower metabolic demand on transplanted islets. Long-term clamp studies are needed to confirm these results (Diabetes/Metabolism Research and Reviews)

Categories: News, Transplantation
Tags: islet cell, Type 1 Diabetes

Categories: Transplantation
Tags: islet cell, Type 1 Diabetes

Who Should Be Considered for Islet Transplantation Alone?

March 15th 2017

The selection of appropriate candidates, optimizing donor selection, the use of an optimized protocol for islet cell extraction, and immunosuppression therapy have been proved to be the key criteria for a favorable outcome in islet transplantation (Current Diabetes Reports)

Categories: News, Transplantation
Tags: Islet, selection

Categories: Transplantation
Tags: Islet, selection

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

April 19th 2016

Transplanted PHPI provided glycemic control, restoration of hypoglycemia awareness, and protection from SHEs in subjects with intractable IAH and SHEs … Islet transplantation should be considered for patients with T1D and IAH in whom other, less invasive current treatments would have been ineffective in preventing SHEs (Diabetes Care)

Categories: News, Transplantation
Tags: human Islets, Type 2 Diabetes

Categories: Transplantation
Tags: human Islets, Type 2 Diabetes

Diabetes Research Institute’s First Patient In BioHub Trial No Longer Requires Insulin Therapy

September 9th 2015

This was the first tissue engineered islet transplant using a ‘biodegradable scaffold’ implanted on the surface of the omentum (PR Newswire)

Categories: News, Transplantation
Tags: omentum

Categories: Transplantation
Tags: omentum

Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial

August 26th 2015

This was the first transplant of islets on the surface of the omentum, a highly vascularized tissue covering abdominal organs, using a biologic, fully re-absorbable scaffold technique (PR Newswire)

Categories: News, Transplantation
Tags: omentum

Categories: Transplantation
Tags: omentum

Current status of clinical islet transplantation

January 9th 2014

This brief overview presents recent progress in Islet transplantation. A concise historical perspective is provided, along with the latest efforts to improve islet engraftment, immune protection and ultimately, prolonged graft survival(World Journal of Transplantation)

Categories: News, Transplantation

Categories: Transplantation

Transplantation – the CIT07 Protocol & ß-Cell Secretory Capacity

September 21st 2013

These data indicate that engrafted islet ß-cell mass is markedly improved with the CIT07 protocol, especially given more frequent use of single islet donors. Although several peritransplant differences may have each contributed to this improvement, the lack of deterioration in ß-cell secretory capacity over time in the CIT07 protocol suggests that low-dose tacrolimus and sirolimus are not toxic to islets (Diabetes)

Categories: News, Transplantation

Categories: Transplantation

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