These findings suggest that hospital admission rates for all DFD conditions are considerably higher than those for amputations alone and, thus, the more common practice of reporting admission rates only for amputations may substantially underestimate the burden of DFD (Diabetologia)
Diabetes News
Category: Wound Care
3D bioprinted scaffolds for diabetic wound-healing applications
This proof of concept study demonstrates the innovative potential of bioprinting technologies in fabrication of antibiotic scaffolds for the treatment of DFU (Drug Delivery and Translational Research)
Impact of case-mix adjustment on observed variation in the healing of diabetic foot ulcers at 12 weeks using data from the National Diabetes Foot Care Audit of England and Wales: a cohort study
Variation in the healing of diabetic foot ulcers between specialist services in England and Wales persisted after adjusting for demographic characteristics, ulcer severity, smoking, body mass index and co-morbidities. We conclude that other factors contribute to variation in healing of diabetic foot ulcers and include the time to specialist assessment (Diabetic Medicine)
Clinical usefulness of quantifying microbial load from diabetic foot ulcers: a multicenter cohort study
Since patients with high microbial load had a worse outcome, quantitative cultures from DFUs can identify patients who would benefit from antibiotic therapy (Diabetes Research and Clinical Practice)
How Effective are Nano-Based Dressings in Diabetic Wound Healing? A Comprehensive Review of Literature
This review will focus on the effects of diabetes on wound healing, introduce the properties, preparation methods and action mechanism of nanoparticles in wound healing, and describe the effects and application status of various nanoparticle-loaded dressings in diabetes-related chronic wound healing (International Journal of Nanomedicine)
Mechanism and application of exosomes in the wound healing process in diabetes mellitus
Most of the recent studies are still in the preclinical stage, and the relevant drugs have not been approved for use. In the future, more research are required to determine the scope of application of exosomes and determine the production routes for a large number of clinical uses. Further studies on exosomes may provide a way to treat diabetic wounds in the future (Diabetes Research and Clinical Practice)
Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers
In this review, we briefly summarize the current knowledge regarding the functional roles and potential mechanisms of reported lncRNAs in regulating DFU (Dove Press)
Factors Associated With Key Outcomes in Diabetes Related Foot Disease: A Prospective Observational Study
This prospective study supports the ability of the WIfI classification system to predict one year key clinical outcomes in a diabetic population with foot ulcers. It also demonstrated that grip strength may be a useful predictor of wound healing (European Journal of Vascular & Endovascular Surgery)
Effectiveness of fast-track pathway for diabetic foot ulcerations
After the FTP implementation, less cases of LR were reported in comparison to ER. ER was an independent predictor of positive outcomes such as healing, healing time, limb salvage, hospitalization, and survival (Acta Diabetologica)
Treatment of chronic diabetic foot ulcers with adipose‐derived stromal vascular fraction cell injections: Safety and evidence of efficacy at 1 year
These results indicate that SVF can be safely used to treat chronic DFU, with evidence of efficacy (wound healing) and mechanisms of action that include vascular repair and/or angiogenesis (Stem Cells Translational Medicine)
The Role of Recombinant Proteins and Growth Factors in the Management of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials
Overall, there is a greater agreement on the effectiveness of EGF to enhance the healing of diabetic ulcers. Nevertheless, extant evidence is lacking for other agents since few trials have been conducted for most of the growth factors and available studies are heterogeneous in their methodologies (Journal of Diabetes Research)
Surgery for the diabetic foot: A key component of care
This brief overview from the Association for Diabetic Foot Surgeons describes common conditions best treated by surgical interventions, as well as specific indications (Diabetes/Metabolism Research and Reviews)
Unilateral remote temperature monitoring to predict future ulceration for the diabetic foot in remission
Given the high incidence of subsequent diabetic foot complications to the sound foot in patients with a history of proximal LEA and patients being treated for a wound, practice of daily temperature monitoring of a single foot has the potential to significantly improve outcomes and reduce resource utilization in this challenging high-risk population (BMJ)
Diabetic foot ulcer incidence and survival with improved diabetic foot services: an 18‐year study
Integrated care for the diabetic foot in one National Health Service (NHS) health service area over 18 years was associated with a reduction in first presentations of diabetic foot ulceration, but failed to reduce recurrent ulceration. Cumulative prevalence of all ulcers continues to increase (Diabetic Medicine)
Clinical Commissioning Policy: Hyperbaric oxygen therapy for diabetic lower limb ulceration (diabetic foot ulcer) (all ages)
NHS England has carefully reviewed the evidence to treat diabetic lower limb ulceration with hyperbaric oxygen therapy. We have concluded that there is not enough evidence to make the treatment available at this time.
Remission in diabetic foot infections: Duration of antibiotic therapy and other possible associated factors
Our analysis found no threshold for the optimal duration or route of administration of antibiotic therapy to prevent recurrences of DFI. These limited data might support possibly shorter treatment duration for patients with DFI (Diabetes, Obesity and Metabolism)
Glucagon-like peptide-1 analogue liraglutide facilitates wound healing by activating PI3K/Akt pathway in keratinocytes
Our study suggests that liraglutide may be a potential target drug to improve skin ulcer with diabetes through its specific receptor GLP-1 (Diabetes Research and Clinical Practice)
Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot
We have found an increased A-V flux of IL-6 in the acute diabetic Charcot foot compared to the healthy foot in the same patients (Journal of Diabetes Research)
Efficacy of Low-Level Light Therapy for Treatment of Diabetic Foot Ulcer
LLLT was recognized as a potential method in the comprehensive treatment of DFUs. Further well designed and high-quality studies are required to confirm the role of LLLT in the management of DFUs (Diabetes Research and Clinical Practice)
Skin hydration of the heel with fissure in patients with diabetes: a cross-sectional observational study
To prevent heel fissures, moisturizing care should aim at achieving skin hydration of 20%. If skin hydration is <20%, prevention of fissures may warrant not only specialized moisturizing care but also consideration of treatment for tinea pedis (Chronic Wound Care Management and Research)
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