Combined, our analyses provide enhanced resolution of the mycobiome during impaired wound healing, its role in chronic disease, and impact on clinical outcomes (mBio)
Diabetes News
Category: Wound Care
Generation of Induced Pluripotent Stem Cells from Diabetic Foot Ulcer Fibroblasts Using a Nonintegrative Sendai Virus
These results have established for the first time that multiple, DFU-derived fibroblast cell lines can be reprogrammed with efficiencies similar to control fibroblasts, thus demonstrating their utility for future regenerative therapy of DFUs (Cellular Reprogramming)
Cognitive Dysfunction: Part and Parcel of the Diabetic Foot
Individuals with diabetic foot ulcers were found to possess fewer cognitive resources than individuals with diabetes without this complication. Thus, they appear to face more self-treatment challenges, while possessing significantly fewer cognitive resources (Diabetes Care)
Illness Beliefs Predict Mortality in Patients with Diabetic Foot Ulcers
Our data indicate that illness beliefs have a significant independent effect on survival in patients with diabetes and foot ulceration. These findings suggest that illness beliefs could improve our understanding of mortality risk in this patient group and could also be the basis for future therapeutic interventions to improve survival (PLoS ONE)
Increased Mortality in Diabetic Foot Ulcer Patients: The Significance of Ulcer Type
IHD is the major cause of premature mortality in DFU patients with the neuropathic foot ulcer patients being at a greater risk (Journal of Diabetes Research)
Chronic wounds: advanced wound dressings and antimicrobial dressings
This evidence summary discusses the best available evidence for advanced wound dressings and antimicrobial dressings for managing common chronic wounds (diabetic foot ulcers, pressure ulcers, venous leg ulcers and infected wounds) (NICE)
Towards next generation maggot debridement therapy: transgenic Lucilia sericata larvae that produce and secrete a human growth factor
Our system could potentially be used to deliver a variety of growth factors and anti-microbial peptides to the wound environment with the aim of enhancing wound healing, thereby improving patient outcome in a cost-effective manner (BMC Biotechnology)
Risk Factors for Foot Amputation in Patients Hospitalized for Diabetic Foot Infection
Knowledge of these factors is critical to enable multidisciplinary teams to develop treatment plans for these patients so as to prevent the need for amputation (Journal of Diabetes Research)
Intensive versus conventional glycaemic control for treating diabetic foot ulcers
This review was performed to clarify the effect of intensive glycaemic control on the healing of foot ulcers in people with diabetes (Cochrane Library)
Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb
HBOT does not offer an additional advantage to comprehensive wound care in reducing the indication for amputation or facilitating wound healing in patients with chronic DFUs (Diabetes Care)
Growth factors for treating diabetic foot ulcers
This Cochrane review found evidence suggesting that growth factors might be useful for increasing complete wound closure of foot ulcers in people with diabetes , though this conclusion is based on randomised clinical trials with a high risk of bias due to pitfalls in design and execution of the included trials
Managing the diabetic foot
The role of the healthcare professional is to empower patients with the knowledge to manage this chronic disease and understand why they need to: (Nursing in Practice)
Maggot debridement therapy promotes diabetic foot wound healing by up-regulating endothelial cell activity
These results demonstrate that MDT and maggot ES can promote diabetic foot wound healing by up-regulating endothelial cell activity (Journal of Diabetes and Its Complications)
Influence of Wound Scores and Microbiology on the Outcome of the Diabetic Foot Syndrome
The presence of osteomyelitis and the location of the wound in the forefoot predict minor amputation and elevated CRP levels predict major amputation. In the follow-up a low ABI predicts major amputation (Journal of Diabetes and Its Complications)
Efficacy and Safety Evaluation of Systemic Extremely Low Frequency Magnetic Fields Used in the Healing of Diabetic Foot Ulcers–Phase II Data
Healing time was independent of the amount of blood exposed to ELF-MF used in this trial. ELF-MFs are effective and safe and could be applied to non-healing DFUs in conjunction with other preventive interventions to reduce DFUs complications (Archives of Medical Research)
The growing evidence for the use of Platelet-Rich Plasma on diabetic chronic wounds: A review and a proposal for a new standard care
As PRP may be beneficial, we suggest using PRP on diabetic ulcers which remain unhealed after standard treatment (Wound Repair and Regeneration)
Treatment of chronic plantar ulcer of the diabetic foot using an irremovable windowed fiberglass cast boot
The treatment of old and deep NPUs of the diabetic foot by wearing a WCB without opening the boot prior to healing, offers very high ulcer recovery levels (Diabetes/Metabolism Research and Reviews)
Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing
These data collectively increasingly substantiate a functional role for CTGF in human diabetic foot ulcers (Journal of Diabetes Research)
Therapeutic Potential of Adipose-Derived SSEA-3-Positive Muse Cells for Treating Diabetic Skin Ulcers
The selected population of ASCs has greater therapeutic effects to accelerate impaired wound healing associated with type 1 diabetes. These cells can be achieved in large amounts with minimal morbidity and could be a practical tool for a variety of stem cell-depleted or ischemic conditions of various organs and tissues (Stem Cells Translational Medicine)
A pilot study evaluating non-contact low-frequency ultrasound and underlying molecular mechanism on diabetic foot ulcers
This proof-of-concept pilot study demonstrates that NCLF-US is effective in treating neuropathic diabetic foot ulcers through, at least in part, inhibiting pro-inflammatory cytokines in chronic wound and improving tissue regeneration (International Wound Journal)
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