Plasma Exposure Insulin Glargine and Metabolites – Subcutaneous Injection

After subcutaneous injection of glargine in male subjects with type 1 diabetes, exposure to glargine is marginal, if any, even at supratherapeutic doses. Glargine is rapidly and nearly completely processed to M1 (21A-Gly-human insulin), which mediates the metabolic effect of injected glargine (Diabetes Care)