Relation between augmentation index and adiponectin during one-year metformin treatment for nonalcoholic steatohepatosis

Metformin treatment was associated with significant decrease in AI during one year treatment in NAFLD patients. These beneficial vascular effects was associated with exposure to metformin per se as well as change in adiponectin levels suggesting that metformin may mediate its vascular effects via glicemic control-independent mechanisms (Cardiovascular Diabetology)