Role of GLP-1 in the Enteroinsulinar Axis in T2D

In this cohort of diabetic patients with a substantial incretin effect, GLP-1 contributed about 50% to the insulin excursion after an OGT both with and without DPP-4 inhibition. Thus, a significant DPP-4 sensitive glucose lowering mechanism contributes to glycemic control in diabetic patients that may be not mediated by circulating GLP-1 (Diabetes)