Basal low-level proliferation of β-cells during adulthood is important for maintaining sufficient β-cell mass and good glucose tolerance and β-cell FoxM1 underlies this mechanism. Preserving β-cell FoxM1 activity may prevent impairment of glucose tolerance with advancing age (Journal of Diabetes Investigation)
Diabetes News
Tag: β cells
Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
The findings reveal unique GABAA receptors signaling in human islets β cells that is GABA concentration-dependent, differentially regulated by drugs, modulates insulin secretion and is altered in T2D (EBioMedicine)
Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose
The present findings provide new insights into the regulation of islet function by individual β cells and the mechanisms that likely target and impair this during type 2 diabetes pathogenesis and treatment (Cell Metabolism)
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