From several epidemiological studies it appears that diabetes-related autoimmunity is not a main factor in the aetiology of GDM, accounting for less than 10% of all cases (BMC Endocrine Disorders)
Diabetes News
Tag: autoantibodies
The elusive role of B lymphocytes and islet autoantibodies in (human) type 1 diabetes
These new findings may guide the research community to design experiments to unambiguously define whether B lymphocytes or their products function as fire, smoke or perhaps ice water in the immunopathogenesis of type 1 diabetes (Diabetologia)
Type 1 diabetes: a disease of developmental origins
The majority of children who present with clinical type 1 diabetes are of school age; however 80% of children who develop type 1 diabetes by 18 years of age will have detectable islet autoantibodies by 3 years of age. The evolving concept that type 1 diabetes in many children has developmental origins has directed research questions in search of prevention back to pregnancy and early life. (Pediatric Diabetes)
Positivity for Zinc Transporter 8 Autoantibodies at Diagnosis Is Subsequently Associated With Reduced β-Cell Function and Higher Exogenous Insulin Requirement in Children and Adolescents With Type 1 Diabetes
Positivity for ZnT8A at diagnosis seems to reflect a more aggressive disease process before and after diagnosis (Diabetes Care)
Islet autoantibody status in a multi-ethnic UK clinic cohort of children presenting with diabetes
Islet autoantibody positivity was associated with a more severe phenotype, as demonstrated by poorer glycaemic control, regardless of assigned diabetes subtype. Positivity did not differ by ethnic group (Archives of Disease in Childhood)
Relationship of adiponectin and leptin with autoimmunity in children with new-onset type 1 diabetes: a pilot study
These pilot data showing those with the fewest autoantibodies had the lowest adiponectin levels, supporting the concept that insulin-resistant subjects may present with clinical T1D at earlier stages of β-cell damage (Pediatric Diabetes)
Biomarkers related to severe hypoglycaemia and lack of good glycaemic control in ACCORD
C-peptide and islet autoantibodies may serve as biomarkers to predict the risk of severe hypoglycaemia during intensification of type 2 diabetes treatment (Diabetologia)
Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY)
In the TEDDY study, children who have progressed to diabetes usually expressed two or more autoantibodies. Higher IAA and IA-2A levels, but not GADA levels, increased the risk of diabetes in those children who were persistently autoantibody positive (Diabetes Care)
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