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Diabetes News

Tag: autoantibodies


Autoantibodies against zinc transporter 8 further stratify the autoantibody-defined risk for type 1 diabetes in a general population of schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes

August 23rd 2020

Zinc transporter 8 autoantibodies are useful markers for prediction of type 1 diabetes in a general population, further stratifying the risk of progression in autoantibody-positive children (Diabetic Medicine)

Categories: News, Screening
Tags: autoantibodies

Categories: Screening
Tags: autoantibodies

Prevalence of diabetes-associated autoantibodies among patients presenting with type 2 diabetes and related metabolic differences

August 12th 2020

Patients with LADA positive for either of the autoantibodies (GAD65, ZnT8 and IAA) presented with worse glycemic control. Measurement of these autoantibodies can assist in discrimination of these patients and help with earlier control of glycemic profile (Primary Care Diabetes)

Categories: Monitoring, News
Tags: autoantibodies, Type 2 Diabetes

Categories: Monitoring
Tags: autoantibodies, Type 2 Diabetes

Testing for type 1 diabetes autoantibodies in gestational diabetes mellitus (GDM): is it clinically useful?

May 4th 2019

From several epidemiological studies it appears that diabetes-related autoimmunity is not a main factor in the aetiology of GDM, accounting for less than 10% of all cases (BMC Endocrine Disorders)

Categories: Gestational, News
Tags: autoantibodies, Type 1 Diabetes

Categories: Gestational
Tags: autoantibodies, Type 1 Diabetes

The elusive role of B lymphocytes and islet autoantibodies in (human) type 1 diabetes

May 31st 2017

These new findings may guide the research community to design experiments to unambiguously define whether B lymphocytes or their products function as fire, smoke or perhaps ice water in the immunopathogenesis of type 1 diabetes (Diabetologia)

Categories: News, Pathology
Tags: autoantibodies, B lymphocytes, Type 1 Diabetes

Categories: Pathology
Tags: autoantibodies, B lymphocytes, Type 1 Diabetes

Type 1 diabetes: a disease of developmental origins

August 16th 2016

The majority of children who present with clinical type 1 diabetes are of school age; however 80% of children who develop type 1 diabetes by 18 years of age will have detectable islet autoantibodies by 3 years of age. The evolving concept that type 1 diabetes in many children has developmental origins has directed research questions in search of prevention back to pregnancy and early life. (Pediatric Diabetes)

Categories: News, Screening
Tags: autoantibodies, Type 1 Diabetes

Categories: Screening
Tags: autoantibodies, Type 1 Diabetes

Positivity for Zinc Transporter 8 Autoantibodies at Diagnosis Is Subsequently Associated With Reduced β-Cell Function and Higher Exogenous Insulin Requirement in Children and Adolescents With Type 1 Diabetes

November 2nd 2015

Positivity for ZnT8A at diagnosis seems to reflect a more aggressive disease process before and after diagnosis (Diabetes Care)

Categories: News, Pathology
Tags: autoantibodies, Type 1 Diabetes, Zinc Transporter 8

Categories: Pathology
Tags: autoantibodies, Type 1 Diabetes, Zinc Transporter 8

Islet autoantibody status in a multi-ethnic UK clinic cohort of children presenting with diabetes

April 9th 2015

Islet autoantibody positivity was associated with a more severe phenotype, as demonstrated by poorer glycaemic control, regardless of assigned diabetes subtype. Positivity did not differ by ethnic group (Archives of Disease in Childhood)

Categories: News, Paediatrics
Tags: autoantibodies

Categories: Paediatrics
Tags: autoantibodies

Relationship of adiponectin and leptin with autoimmunity in children with new-onset type 1 diabetes: a pilot study

March 9th 2015

These pilot data showing those with the fewest autoantibodies had the lowest adiponectin levels, supporting the concept that insulin-resistant subjects may present with clinical T1D at earlier stages of β-cell damage (Pediatric Diabetes)

Categories: News, Pathology
Tags: adiponectin, autoantibodies

Categories: Pathology
Tags: adiponectin, autoantibodies

Biomarkers related to severe hypoglycaemia and lack of good glycaemic control in ACCORD

February 25th 2015

C-peptide and islet autoantibodies may serve as biomarkers to predict the risk of severe hypoglycaemia during intensification of type 2 diabetes treatment (Diabetologia)

Categories: Monitoring, News
Tags: autoantibodies, biomarkers, C-peptide

Categories: Monitoring
Tags: autoantibodies, biomarkers, C-peptide

Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY)

February 16th 2015

In the TEDDY study, children who have progressed to diabetes usually expressed two or more autoantibodies. Higher IAA and IA-2A levels, but not GADA levels, increased the risk of diabetes in those children who were persistently autoantibody positive (Diabetes Care)

Categories: News, Paediatrics
Tags: autoantibodies

Categories: Paediatrics
Tags: autoantibodies

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