In adolescents with obesity, the use of liraglutide (3.0 mg) plus lifestyle therapy led to a significantly greater reduction in the BMI standard-deviation score than placebo plus lifestyle therapy (NEJM)
Diabetes News
Tag: BMI
Relationship Between Body Mass Index, Antidiabetic Agents, and Midterm Mortality in Patients With Both Type 2 Diabetes Mellitus and Acute Coronary Syndrome
In patients with type 2 diabetes mellitus and acute coronary syndrome, the relationship between body mass index and mortality rate is U‐shaped, with class I obesity representing the nadir and normal weight the peak. The protective effect of obesity disappeared in patients treated with insulin (JAHA)
Investigating the Association Between Baseline Characteristics (HbA1c and Body Mass Index) and Clinical Outcomes of Fast-Acting Insulin Aspart in People with Diabetes
In participants with T1D and T2D, treatment differences (for change in HbA1c and overall hypoglycaemia) between mealtime faster aspart and insulin comparators were similar to the corresponding overall analysis across baseline HbA1c and BMI subgroups. The finding of a lower total daily insulin dose in participants with obesity (BMI > 30 kg/m2) and T1D treated with faster aspart, versus those treated with IAsp, may warrant further investigation (Diabetes Therapy)
Ethnicity-specific association of BMI levels at diagnosis of type 2 diabetes with cardiovascular disease and all-cause mortality risk
This study suggests a paradoxical association of BMI with cardiovascular and mortality risks in different ethnic groups, which may partially be driven by different cardiovascular and glycaemic risk profiles at diagnosis (Acta Diabetologica)
Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment
A substantial number of cancer cases are attributable to diabetes and high BMI. As the prevalence of these cancer risk factors increases, clinical and public health efforts should focus on identifying optimal preventive and screening measures for whole populations and individual patients (The Lancet Diabetes & Endocrinology)
A risk score of BMI, HbA1c and triglycerides predicts future glycemic control in type 2 diabetes
The developed model can effectively explain heterogeneity in future glycemic response of patients with type 2 diabetes. It can therefore be used in clinical practice as a quick and easy tool to provide tailored diabetes care (Diabetes, Obesity and Metabolism)
Detection and Management of Diabetes in England: Results from the Health Survey for England
In the UK current guidance recommends practitioners consider testing for diabetes among South-east Asians and Chinese where BMI exceeds 23. Our findings suggest that the risk experienced by Asians in disease detection is independent of BMI and may warrant a more active screening policy than currently recommended (Diabetes Therapy)
Body mass index and all-cause mortality among type 2 diabetes mellitus patients: Findings from the 5-year follow-up of the MADIABETES cohort
In an outpatient T2DM Mediterranean population sample, low BMI predicted all-cause mortality only in males (European Journal of Internal Medicine)
Health Effects of Overweight and Obesity in 195 Countries over 25 Years
The rapid increase in the prevalence and disease burden of elevated BMI highlights the need for continued focus on surveillance of BMI and identification, implementation, and evaluation of evidence-based interventions to address this problem (NEJM)
Nonlinear association of BMI with all-cause and cardiovascular mortality in type 2 diabetes mellitus
In type 2 diabetes, BMI is nonlinearly associated with all-cause mortality with lowest risk in the overweight group in both men and women. Further research is needed to clarify the relationship with cardiovascular mortality and assess causality and sex differences (Diabetologia)
BMI at Age 17 Years and Diabetes Mortality in Midlife: A Nationwide Cohort of 2.3 Million Adolescents
Adolescent BMI, including values within the currently accepted “normal” range, strongly predicts DM mortality up to the seventh decade (Diabetes Care)
Body Mass Index at Age 17 and Diabetes Mortality in Midlife: A Nationwide Cohort of 2.3 Million Adolescents
Adolescent BMI, including values within the currently accepted “normal” range, strongly predicts DM mortality up to the seventh decade. The increasing prevalence of childhood and adolescent overweight and obesity points to a substantially increased future adult DM burden (Diabetes Care)
Structural equation model for estimating risk factors in type 2 diabetes mellitus in a Middle Eastern setting: evidence from the STEPS Qatar
This study’s main finding is that triglyceride levels and BMI are the main variables directly affecting diabetes status in the Qatari population (BMJ Open, Diabetes Research & Care)
Risks of Myocardial Infarction, Death, and Diabetes in Identical Twin Pairs With Different Body Mass Indexes
In MZ twin pairs, higher BMI was not associated with an increased risk of MI or death but was associated with the onset of diabetes (JAMA Internal Medicine)
Normal-Weight Central Obesity: Implications for Total and Cardiovascular Mortality
Normal-weight central obesity defined by WHR is associated with higher mortality than BMI-defined obesity, particularly in the absence of central fat distribution (Annals of Internal Medicine)
Type 2 diabetes in migrant south Asians: mechanisms, mitigation, and management
South Asians, particularly when living in high-income countries, are at a substantially elevated risk of type 2 diabetes compared with white Europeans, and typically develop the disease 5–10 years earlier and at a lower BMI (The Lancet Diabetes & Endocrinology)
The Obesity Paradox in Type 2 Diabetes Mellitus: Relationship of Body Mass Index to Prognosis: A Cohort Study
In this cohort, patients with type 2 diabetes who were overweight or obese were more likely to be hospitalized for cardiovascular reasons. Being overweight was associated with a lower mortality risk, but being obese was not (Annals of Internal Medicine)
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