Our results demonstrated that EMPA, mainly acting on SGLT2, prevented DNA methylation changes induced by high glucose and provided evidence of a new mechanism by which SGLT2i can exert cardio-beneficial effects (Cardiovascular Diabetology)
Diabetes News
Tag: epigenetic
Gestational diabetes mellitus, epigenetic age and offspring metabolism
In this study, children exposed to GDM experience greater extrinsic EAA, which is associated with lower insulin sensitivity and greater insulin secretion. Further studies are needed to determine the directionality of these associations (Diabetic Medicine)
Novel Subgroups of Type 2 Diabetes Display Different Epigenetic Patterns That Associate With Future Diabetic Complications
We identified differential epigenetic patterns between T2D subgroups that associated with future diabetic complications. These data support a reclassification of diabetes and the need for precision medicine in T2D subgroups (Diabetes Care)
A Double-Edged Sword against Type 1 Diabetes
An inhibitor of a class of epigenetic-modifier proteins prevents and cures type 1 diabetes in a mouse model, probably through a dual effect on the macrophage and beta cell (NEJM)
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