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Diabetes News

Tag: Insulin resistance


Oral Fat Tolerance Testing Identifies Abnormal Pancreatic β-Cell Function and Insulin Resistance in Individuals with Normal Glucose Tolerance

June 9th 2022

In individuals with normal glucose tolerance, β-cell function and insulin sensitivity gradually decrease with a deterioration in the lipid profile. Not only fasting TG but also postprandial TG concentrations are independent risk factors for impaired β-cell function and insulin resistance (Journal of Diabetes Investigation)

Categories: News, Screening
Tags: Insulin resistance, lipids, β-cell

Categories: Screening
Tags: Insulin resistance, lipids, β-cell

Type 2 diabetes classification: a data-driven cluster study of the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort

April 18th 2022

Different HOMA2-based approaches did not classify patients with T2D in a consistent manner. The T2D classes characterized by high insulin resistance/hyperinsulinemia appeared most distinct (BMJ Open, Diabetes Research & Care)

Categories: Genetics, Monitoring, News
Tags: hyperinsulinemia, Insulin resistance, Type 2 Diabetes

Categories: Genetics, Monitoring
Tags: hyperinsulinemia, Insulin resistance, Type 2 Diabetes

Effects of canagliflozin and metformin on insulin resistance and visceral adipose tissue in people with newly-diagnosed type 2 diabetes

February 11th 2022

Canagliflozin reduces visceral adipose tissue and improves blood glucose, insulin resistance and systemic inflammation in people with newly-diagnosed type 2 diabetes (BMC Endocrine Disorders volume)

Categories: Medication, News
Tags: canagliflozin, Insulin resistance, metformin, Type 2 Diabetes

Categories: Medication
Tags: canagliflozin, Insulin resistance, metformin, Type 2 Diabetes

Changes of insulin resistance status and development of complications in type 1 diabetes mellitus: Analysis of DCCT/EDIC study

January 23rd 2022

This study highlights the importance of IR changes represented by eGDR in the development of diabetic complications. Patients with T1D and IR may require intensive therapy (Diabetes Research and Clinical Practice)

Categories: News, Pathology
Tags: Insulin resistance, Type 1 Diabetes

Categories: Pathology
Tags: Insulin resistance, Type 1 Diabetes

Elevated serum uric acid is a facilitating mechanism for insulin resistance mediated accumulation of visceral adipose tissue

January 12th 2022

Elevated SUA acts as a mediator inside the bidirectional relationship between IR and VAT accumulation and these observations could be applicable at a phenotype scale (Clinical Endocrinology)

Categories: News, Pathology
Tags: Insulin resistance, uric acid

Categories: Pathology
Tags: Insulin resistance, uric acid

Adipose Tissue Insulin Resistance Is Longitudinally Associated With Adipose Tissue Dysfunction, Circulating Lipids, and Dysglycemia: The PROMISE Cohort

July 21st 2021

Our findings demonstrate that adipose tissue insulin resistance is prospectively associated with adipose tissue function, HDL, TG, and incident dysglycemia (Diabetes Care)

Categories: News, Pathology
Tags: Insulin resistance, Type 2 Diabetes

Categories: Pathology
Tags: Insulin resistance, Type 2 Diabetes

One Year of Dapaglifozin Add-On Therapy Ameliorates Surrogate Indexes of Insulin Resistance and Adiposity in Patients with Type 2 Diabetes Mellitus

April 30th 2021

Dapagliflozin treatment significantly reduced surrogate indexes of insulin resistance and adiposity in patients with T2D (Diabetes Therapy)

Categories: Medication, News
Tags: Dapaglifozin, Insulin resistance, Type 2 Diabetes

Categories: Medication
Tags: Dapaglifozin, Insulin resistance, Type 2 Diabetes

Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects

September 30th 2020

Soluble EGFR, a hepatokine, is correlated with insulin resistance in the liver, while adipsin, an adipokine, is associated with adipose insulin resistance (Diabetology & Metabolic Syndrome)

Categories: News, Screening
Tags: Insulin resistance, Type 2 Diabetes

Categories: Screening
Tags: Insulin resistance, Type 2 Diabetes

Effect of sidt2 Gene on Cell Insulin Resistance and Its Molecular Mechanism

September 14th 2020

sidt2 knockout can reduce glucose uptake in peripheral tissue under insulin stimulation, which may lead to peripheral tissue insulin resistance by affecting the IRS-1 signal pathway (Journal of Diabetes Research)

Categories: Genetics, News
Tags: Insulin resistance

Categories: Genetics
Tags: Insulin resistance

Obesity is Associated with Increased Basal and Postprandial β-Cell Insulin Secretion Even in the Absence of Insulin Resistance

July 11th 2020

These results demonstrate that increased insulin secretion in people with obesity is associated with excess adiposity itself and is not simply a compensatory response to insulin resistance (Diabetes)

Categories: News, Pathology
Tags: Insulin resistance

Categories: Pathology
Tags: Insulin resistance

Progression of Insulin Resistance: A Link between Risk Factors and the Incidence of Diabetes

February 6th 2020

Change of IR can be used as a surrogate marker of incident diabetes. The progression of IR is an important pathophysiologic link between risk factors and the incidence of diabetes (Diabetes Research and Clinical Practice)

Categories: News, Pathology
Tags: Insulin resistance

Categories: Pathology
Tags: Insulin resistance

Different Analysis of β-Cell Dysfunction as Fasting Glucose Progresses in Obese and Nonobese Newly Diagnosed Type 2 Diabetic Patients

October 28th 2019

During the progression of baseline FBG, β-cell dysfunction and insulin resistance worsened. As FBG increased, increased BMI had a positive influence on β-cell dysfunction in all FBG groups. The independent factors that correlated to EISI differed with the increasing of baseline FBG (Journal of Diabetes Research)

Categories: News, Pathology
Tags: beta cells, Insulin resistance, Type 2 Diabetes

Categories: Pathology
Tags: beta cells, Insulin resistance, Type 2 Diabetes

Association between insulin resistance and haematological parameters: a cohort study from adolescence to adulthood

June 17th 2019

Both longitudinal and cross‐sectional analyses support the hypothesis that insulin resistance is associated with increased red blood cells count and haematocrit in young adults, even within normal ranges of insulin and glucose (Diabetes/Metabolism Research and Reviews)

Categories: News, Pathology
Tags: Insulin resistance

Categories: Pathology
Tags: Insulin resistance

Inverse association of insulin antibody levels with insulin sensitivity in adults with Type 1 diabetes

February 20th 2018

In adults with recent-onset Type 1 diabetes expressing at least one β-cell-directed antibody, insulin sensitivity is inversely related to insulin antibody titres, but not to other autoantibodies. Our finding may allow for the identification of insulin resistance in adults with high levels of insulin antibodies (Diabetic Medicine)

Categories: News, Pathology
Tags: antibody, Insulin resistance, Type 1 Diabetes

Categories: Pathology
Tags: antibody, Insulin resistance, Type 1 Diabetes

A 2-year Trial of Intermittent Insulin Therapy versus Metformin for the Preservation of Beta-cell Function after Initial Short-term Intensive Insulin Induction in early Type 2 Diabetes

January 29th 2018

Following induction IIT, metformin was superior to intermittent IIT for maintaining beta-cell function and glycemic control over 2-years. The strategy of induction and maintenance therapy to preserve beta-cell function warrants exploration in early T2DM (Diabetes, Obesity and Metabolism)

Categories: News, Treatment
Tags: beta cell, Insulin resistance, metformin, Type 2 Diabetes

Categories: Treatment
Tags: beta cell, Insulin resistance, metformin, Type 2 Diabetes

Sex-specific differences in insulin resistance in type 1 diabetes: The CACTI cohort

January 10th 2018

We found that type 1 diabetes affected adipose and skeletal muscle insulin sensitivity to a greater extent in women than in men, perhaps contributing to the greater relative increase in cardiovascular risk in women with type 1 diabetes  (Journal of Diabetes and Its Complications)

Categories: News, Pathology
Tags: gender, Insulin resistance, Type 1 Diabetes

Categories: Pathology
Tags: gender, Insulin resistance, Type 1 Diabetes

Hypoglycemia After Initiation of Basal Insulin in Patients with Type 2 Diabetes in the United States: Implications for Treatment Discontinuation and Healthcare Costs and Utilization

August 9th 2017

US patients with T2D who experienced hypoglycemia within 6 months of basal insulin initiation were more likely to discontinue treatment, accompanied by a greater healthcare burden (Advances in Therapy)

Categories: News, Treatment
Tags: insulin, Insulin resistance, Type 2 Diabetes

Categories: Treatment
Tags: insulin, Insulin resistance, Type 2 Diabetes

Characteristics of people with high visit-to-visit glycaemic variability in Type 2 diabetes

July 29th 2017

Intensive treatment resulting in low mean HbA1c was associated with marked increase in HbA1c variability. Irrespective of diabetes control, the greatest visit-to-visit variability was observed in young, insulin resistant men (Diabetic Medicine)

Categories: Monitoring, News
Tags: HbA1c, Insulin resistance, Type 2 Diabetes

Categories: Monitoring
Tags: HbA1c, Insulin resistance, Type 2 Diabetes

Insulin resistance correlates with maculopathy and severity of retinopathy in young adults with Type 1 Diabetes Mellitus

June 28th 2017

IR correlates with more severe retinopathy in young adults with Type 1 DM. This is the first description of a correlation between IR and maculopathy in Type 1 DM, warranting further evaluation. Prospective studies examining whether reducing IR can improve microvascular complications are required (Diabetes Research and Clinical Practice)

Categories: News, Ophthalmology
Tags: Insulin resistance, retinopathy, Type 2 Diabetes

Categories: Ophthalmology
Tags: Insulin resistance, retinopathy, Type 2 Diabetes

Assessing Psychological Insulin Resistance in Type 2 Diabetes: a Critical Comparison of Measures

May 24th 2017

This paper provides guidance on the selection of questionnaires for clinical or research purpose and the development of new, or improvement of existing, questionnaires (Current Diabetes Reports)

Categories: News, Psychological
Tags: Insulin resistance, Type 2 Diabetes

Categories: Psychological
Tags: Insulin resistance, Type 2 Diabetes
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