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Diabetes News

Tag: Ketoacidosis


The management of diabetic ketoacidosis in adults—An updated guideline from the Joint British Diabetes Society for Inpatient Care

March 8th 2022

This article summarises the Joint British Diabetes Societies for Inpatient Care guidelines on the management of ketoacidosis (Diabetic Medicine)

Categories: Management, News
Tags: Ketoacidosis

Categories: Management
Tags: Ketoacidosis

The management of diabetic ketoacidosis in adults

February 28th 2022

An updated guideline from the Joint British Diabetes Society for Inpatient Care (Diabetic Medicine)

Categories: Management, News
Tags: Ketoacidosis

Categories: Management
Tags: Ketoacidosis

Early sepsis markers in patients admitted to intensive care unit with moderate-to-severe diabetic ketoacidosis

May 22nd 2020

At admission, combining procalcitonin and presence of fever may be of value to distinguish ketoacidosis patients with and without proven bacterial infection, admitted in intensive care unit (Annals of Intensive Care)

Categories: News, Treatment
Tags: Ketoacidosis, Sepsis

Categories: Treatment
Tags: Ketoacidosis, Sepsis

Temporal trends in diabetic ketoacidosis at diagnosis of paediatric type 1 diabetes between 2006 and 2016: results from 13 countries in three continents

May 8th 2020

DKA prevalence at type 1 diabetes diagnosis varied considerably across countries, albeit it was generally high and showed a slight increase between 2006 and 2016. Increased awareness of symptoms to prevent delay in diagnosis is warranted, especially in preschool children, adolescents and children from ethnic minority groups (Diabetologia)

Categories: News, Prevalence
Tags: Ketoacidosis, Type 1 Diabetes

Categories: Prevalence
Tags: Ketoacidosis, Type 1 Diabetes

BSPED Interim Guideline for the Management of Children and Young People under the age of 18 years with Diabetic Ketoacidosis

January 31st 2020

These BSPED guidelines are believed to be as safe as possible in the light of current evidence.However, no guidelines can be considered entirely safe as complications may still arise. In particularthe pathophysiology of cerebral oedema is still poorly understood (the British Society for Paediatric Endocrinology and Diabetes)

Categories: News, Paediatrics
Tags: Ketoacidosis

Categories: Paediatrics
Tags: Ketoacidosis

GLP-1 receptor agonists: reports of diabetic ketoacidosis when concomitant insulin was rapidly reduced or discontinued

June 28th 2019

Diabetic ketoacidosis has been reported in patients with type 2 diabetes on a combination of a GLP-1 receptor agonist and insulin who had doses of concomitant insulin rapidly reduced or discontinued. GLP-1 receptor agonists are not substitutes for insulin, and any reduction of insulin should be done in a stepwise manner with careful glucose self-monitoring (Medicines and Healthcare products Regulatory Agency)

Categories: Medication, News
Tags: GLP-1 receptor agonists, Ketoacidosis

Categories: Medication
Tags: GLP-1 receptor agonists, Ketoacidosis

Diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: review of acute decompensated diabetes in adult patients

June 2nd 2019

This review covers recommendations for acute management of diabetic ketoacidosis and HHS, the complications associated with these disorders, and methods for preventing recurrence. It also discusses why many patients who present with these disorders are at high risk for hospital readmissions, early morbidity, and mortality well beyond the acute presentation (BMJ)

Categories: Management, News
Tags: hyperglycemia, hyperosmolar, Ketoacidosis

Categories: Management
Tags: hyperglycemia, hyperosmolar, Ketoacidosis

International Consensus on Risk Management of Diabetic Ketoacidosis in Patients with Type 1 Diabetes Treated with Sodium-Glucose Cotransporter (SGLT) Inhibitors

February 7th 2019

This consensus report reviews current data regarding SGLT- inhibitor use and provides recommendations to enhance the safety of SGLT-inhibitors in people with type 1 diabetes (Diabetes Care)

Categories: Medication, News
Tags: Ketoacidosis, SGLT2 inhibitors

Categories: Medication
Tags: Ketoacidosis, SGLT2 inhibitors

The incidence of diabetic ketoacidosis during Ramadan fasting: a 10-year single-centre retrospective study

January 25th 2019

The present study confirmed that DKA admissions during Ramadan were not significantly higher than the average monthly admissions over ten years. Seasonality trends were not related to Ramadan (Diabetes Research and Clinical Practice)

Categories: News, Prevalence
Tags: Ketoacidosis, Ramadan

Categories: Prevalence
Tags: Ketoacidosis, Ramadan

Trends in Hospital Admission for Diabetic Ketoacidosis in Adults With Type 1 and Type 2 Diabetes in England, 1998–2013: A Retrospective Cohort Study

February 1st 2018

In the previous 2 decades in England, hospitalization for DKA increased in adults with T1DM and in those with T2DM, and associated health care performance did not improve except decreased length of hospital stay (Diabetes Care)

Categories: Audits, News
Tags: Ketoacidosis, Type 1 Diabetes, Type 2 Diabetes

Categories: Audits
Tags: Ketoacidosis, Type 1 Diabetes, Type 2 Diabetes

Effects of Sotagliflozin Added to Insulin in Patients with Type 1 Diabetes

December 13th 2017

Among patients with type 1 diabetes who were receiving insulin, the proportion of patients who achieved a glycated hemoglobin level lower than 7.0% with no severe hypoglycemia or diabetic ketoacidosis was larger in the group that received sotagliflozin than in the placebo group. However, the rate of diabetic ketoacidosis was higher in the sotagliflozin group (NEJM)

Categories: Medication, News
Tags: insulin, Ketoacidosis, sotagliflozin, Type 1 Diabetes

Categories: Medication
Tags: insulin, Ketoacidosis, sotagliflozin, Type 1 Diabetes

Incidence and prevalence of diabetic ketoacidosis (DKA) among adults with type 1 diabetes mellitus (T1D): a systematic literature review

August 15th 2017

To our knowledge, this is the first SLR on the epidemiology of DKA in T1D adults. Despite an increasing prevalence of T1D in recent years, DKA in adults has been poorly characterised. In an era when the benefit–risk profiles of new antidiabetic therapies are being evaluated, including the potential risk of DKA, there is a clear need to better elucidate the expected rate of DKA among T1D adults. (BMJ)

Categories: News, Prevalence
Tags: Ketoacidosis, Type 1 Diabetes

Categories: Prevalence
Tags: Ketoacidosis, Type 1 Diabetes

The cost of treating diabetic ketoacidosis in the UK: a national survey of hospital resource use

July 20th 2017

Despite relatively short stays in hospital, costs for managing episodes of diabetic ketoacidosis in adults were relatively high. Assumptions made in the calculations did not consider prolonged hospital stay due to comorbidities or costs incurred as a loss of productivity. Therefore, the actual costs to the healthcare system and society in general are likely to be substantially higher (Diabetic Medicine)

Categories: Audits, News
Tags: Ketoacidosis

Categories: Audits
Tags: Ketoacidosis

Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes Predicts Poor Long-term Glycemic Control

July 5th 2017

DKA at diagnosis of type 1 diabetes in children predicts poor long-term glycemic control, independent of demographic and socioeconomic factors (Diabetes Care)

Categories: News, Pathology
Tags: Ketoacidosis, Type 1 Diabetes

Categories: Pathology
Tags: Ketoacidosis, Type 1 Diabetes

Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor

June 8th 2017

Shortly after initiation, SGLT2 inhibitors were associated with approximately twice the risk of diabetic ketoacidosis as were DPP4 inhibitors, although cases of diabetic ketoacidosis leading to hospitalization were infrequent (NEJM)

Categories: Medication, News
Tags: Ketoacidosis, SGLT2 inhibitor

Categories: Medication
Tags: Ketoacidosis, SGLT2 inhibitor

SGLT2-I in the Hospital Setting: Diabetic Ketoacidosis and Other Benefits and Concerns

June 8th 2017

We cautiously suggest the use of SGLT2 inhibitors in the hospital. However, these must be used judiciously and the practitioner must be aware of euglycemic diabetic ketoacidosis and its risk factors in this population  (Current Diabetes Reports)

Categories: Medication, News
Tags: Ketoacidosis, SGLT2-I

Categories: Medication
Tags: Ketoacidosis, SGLT2-I

Effects of SGLT-2 inhibitors on diabetic ketoacidosis: A meta-analysis of randomised controlled trials

June 7th 2017

The results of clinical trials summarized in the present meta-analysis reassure us that, when the drug is properly prescribed, the risk of DKA is negligible (Diabetes Research and Clinical Practice)

Categories: Medication, News
Tags: Ketoacidosis, SGLT-2

Categories: Medication
Tags: Ketoacidosis, SGLT-2

Treatment of Diabetic Ketoacidosis (DKA)/Hyperglycemic Hyperosmolar State (HHS): Novel Advances in the Management of Hyperglycemic Crises (UK Versus USA)

April 1st 2017

There is considerable overlap but important differences between the UK and USA guidelines for the management of DKA and HHS. Further research needs to be done to delineate a unifying diagnostic and treatment protocol (Current Diabetes Reports)

Categories: News, Treatment
Tags: Hyperglycemic Crises, hyperosmolar, Ketoacidosis

Categories: Treatment
Tags: Hyperglycemic Crises, hyperosmolar, Ketoacidosis

Self-reported regular alcohol consumption in adolescents and emerging adults with type 1 diabetes

February 1st 2017

A neglected risk factor for diabetic ketoacidosis? Multicenter analysis of 29 630 patients from the DPV registry (Pediatric Diabetes)

Categories: News, Paediatrics
Tags: alcohol, Ketoacidosis, Type 1 Diabetes

Categories: Paediatrics
Tags: alcohol, Ketoacidosis, Type 1 Diabetes

Risk of death following admission to a UK hospital with diabetic ketoacidosis

September 9th 2016

Recurrent DKA is associated with substantial mortality, particularly among young, socially disadvantaged adults with very high HbA1c levels (Diabetologia)

Categories: News, Pathology
Tags: Ketoacidosis

Categories: Pathology
Tags: Ketoacidosis
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