In middle aged or older healthy women followed prospectively over 20 years, LPIR was robustly associated with incident T2D, including among those with an optimal clinical metabolic profile. LPIR improved T2D risk classification and may guide early and targeted prevention strategies (Journal of Clinical Lipidology)
Diabetes News
Tag: lipoprotein
Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study
Our findings demonstrate that prediabetic patients show a lower phenotypic flexibility after external aggression, such as OFTT compared with nondiabetic patients. The postprandial response increases progressively according to non-diabetic, prediabetic and type 2 diabetic state and it is higher in patients with liver insulin-resistance. To identify this subgroup of patients is important to treat more intensively in order to avoid future cardiometabolic complications (Cardiovascular Diabetology)
Children with type 2 diabetes have significantly higher lipoprotein abnormalities than those with type 1 diabetes
Despite no difference in absolute LDL levels, subjects with type 2 diabetes were more likely to have small, dense LDL particle pattern and lower total HDL, HDL-2, and HDL-3 fractions. Furthermore, coalescence of obesity, poor glycemic control and dyslipidemia, particularly in patients with type 2 diabetes, may accelerate CVD progression early in life(Diabetes Research and Clinical Practice)
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