This was the first RCT studying composite clinical, analytic, and microbiome changes in T2DM patients with class 1 obesity after RYGB versus standard medical therapy. The remarkable phenotypic improvement after surgery occurred concomitantly with changes in the gut microbiome, but at a lower level (Diabetology & Metabolic Syndrome)
Diabetes News
Tag: microbiota
The relationship between gut microbiota, short-chain fatty acids and type 2 diabetes mellitus: the possible role of dietary fibre
increasing daily fibre intake in the context of a healthy dietary pattern might be a valid tool to improve microbiota composition and activity to prevent metabolic diseases (Acta Diabetologica)
The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes
The studies discussed in this review suggest that individuals who are obese are likely to have an imbalance in gut microbiota composition and a ‘gut signature’ varying with metabolic control (Current Diabetes Reports)
Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid–Producing Microbiota in the Gut
Our results support the hypothesis that metformin shifts gut microbiota composition through the enrichment of mucin-degrading A. muciniphila as well as several SCFA-producing microbiota. Future studies are needed to determine if these shifts mediate metformin’s glycemic and anti-inflammatory properties (Diabetes Care)
Heritable components of the human fecal microbiome are associated with visceral fat
Our results provide novel insights into the role of the fecal microbiota in cardio-metabolic disease with clear potential for prevention and novel therapies (Genome Biology)
Association between intestinal permeability and fecal microbiota composition in Italian children with beta cell autoimmunity at risk for type 1 diabetes
The results of this study validated the hypothesis that increased intestinal permeability together with differences in microbiota composition are contemporaneously associated with the pre-pathological condition of T1D, in a sample of Italian children (Diabetes/Metabolism Research and Reviews)
Gut microbiota and diet in patients with different glucose tolerance
The representation of Blautia, Serratia was lower in preD than in T2D patients, and even lower in those with normal glucose tolerance (Endocrine Connections)
Genetic Factors Drive Roles of Gut Bacteria in Diabetes and Obesity
Joslin study examines how bacterial and mammalian genomics interact to boost insulin resistance and other metabolic disorders
Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation
Our results suggest that the gut microbiota may play a direct role in the reduction of adiposity observed after bariatric surgery (Cell Metabolism)
Intake of Lactobacillus reuteri Improves Incretin and Insulin Secretion in Glucose Tolerant Humans: A Proof of Concept
Enrichment of gut microbiota with L. reuteri increases insulin secretion, possibly due to augmented incretin release, but does not directly affect insulin sensitivity or body fat distribution. This suggests that oral ingestion of one specific strain may serve as a novel therapeutic approach to improve glucose-dependent insulin release (Diabetes Care)
Alterations in Intestinal Microbiota Correlate with Susceptibility to Type 1 Diabetes
These observations suggest that altered intestinal microbiota may be associated with disease susceptibility (Diabetes)
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