Our results demonstrate that diabetes mellitus induces a marked dysregulation of miRNAs associated with stem cell survival, proliferation and differentiation, and that therapeutic overexpression of prosurvival miR-30c-5p reduced diabetes-induced cell death and loss of MMP in CPCs via the newly identified target for miR-30c-5p, VDAC1 (Diabetologia)
Diabetes News
Tag: microRNAs
Epigenetic effects of metformin: from molecular mechanisms to clinical implications
There is evidence that these alterations influence the epigenome and gene expression, and may contribute to the antidiabetic properties of metformin and potentially protect against cancer, cardiovascular disease, cognitive decline and aging. The expression levels of numerous microRNAs are also reportedly influenced by metformin treatment and may confer antidiabetic and anticancer activities (Diabetes, Obesity and Metabolism)
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