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Diabetes News

Tag: MODY


Causal variants in Maturity Onset Diabetes of the Young (MODY) – A systematic review

November 12th 2021

We expect that this paper will help clinicians interpret MODY genetics results with greater confidence. Discrepancies in certain middle-eastern countries need to be investigated as other genes or factors, like consanguinity may be involved in developing diabetes (BMC Endocrine Disorders)

Categories: News, Pathology
Tags: MODY

Categories: Pathology
Tags: MODY

Treatment Options for MODY Patients: A Systematic Review of Literature

June 24th 2020

Our aim is to provide the reader with an easy-to-read update that can be used to drive the clinician’s therapeutical approach to these patients after the molecular diagnosis (Diabetes Therapy)

Categories: News, Treatment
Tags: MODY

Categories: Treatment
Tags: MODY

Update on clinical screening of maturity-onset diabetes of the young (MODY)

June 9th 2020

The selection of diabetic patients for genetic testing is an ongoing challenge. Metabolic profiling, diabetes onset age, pancreatic antibodies, and C-peptide seem to be useful tools to better select patients for genetic testing (Diabetology & Metabolic Syndrome)

Categories: News, Screening
Tags: MODY

Categories: Screening
Tags: MODY

Successful maintenance on sulfonylurea therapy and low diabetes complication rates in a HNF1A–MODY cohort

October 26th 2015

This study demonstrates that the majority of patients with HNF1A–MODY can be maintained successfully on sulfonylurea therapy with good glycaemic control. We note a significantly lower rate of micro- and macrovascular complications than reported previously (Diabetic Medicine)

Categories: Medication, News
Tags: MODY, sulfonylureas

Categories: Medication
Tags: MODY, sulfonylureas

Postprandial incretin and islet hormone responses and dipeptidyl-peptidase 4 enzymatic activity in patients with maturity onset diabetes of the young

May 27th 2015

The pathophysiology of HNF1A-diabetes includes exaggerated postprandial glucagon responses and increased fasting DPP-4 enzymatic activity, but normal postprandial incretin responses in both patients with GCK-diabetes and HNF1A-diabetes (European Journal of Endocrinology)

Categories: News, Pathology
Tags: DPP4, incretin, MODY

Categories: Pathology
Tags: DPP4, incretin, MODY

Urinary C-Peptide/Creatinine Ratio Can Distinguish Maturity-Onset Diabetes of the Young from Type 1 Diabetes in Children and Adolescents

April 2nd 2015

We showed that the UCPCR and fasting C-peptide levels in children and adolescents can distinguish patients with MODY from patients with T1DM with high specificity and sensitivity (Hormone Research in Paediatrics)

Categories: News, Screening
Tags: C-peptide, creatinine, MODY

Categories: Screening
Tags: C-peptide, creatinine, MODY

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