In patients with type 2 diabetes mellitus and acute coronary syndrome, the relationship between body mass index and mortality rate is U‐shaped, with class I obesity representing the nadir and normal weight the peak. The protective effect of obesity disappeared in patients treated with insulin (JAHA)
Diabetes News
Tag: mortality
The All-Cause Mortality and a Screening Tool to Determine High-Risk Patients among Prevalent Type 2 Diabetes Mellitus Patients
The model has moderate accuracy; the prognostic model can be used as a screening tool to classify T2DM patients who are at higher risk for mortality within five years (Journal of Diabetes Research)
Multiple risk factor control, mortality and cardiovascular events in type 2 diabetes and chronic kidney disease: a population-based cohort study
Multiple risk factor control (MRFC) may lower the increased risks for mortality and cardiovascular events in people with diabetes and CKD (BMJ Open)
How Does Empagliflozin Reduce Cardiovascular Mortality? Insights From a Mediation Analysis of the EMPA-REG OUTCOME Trial
In this exploratory analysis from the EMPA-REG OUTCOME trial, changes in markers of plasma volume were the most important mediators of the reduction in risk of CV death with empagliflozin versus placebo (Diabetes Care)
Pioglitazone and cause-specific risk of mortality in patients with type 2 diabetes: extended analysis from a European multidatabase cohort study
This analysis suggests that pioglitazone is associated with a decrease in both cardiovascular and non-cardiovascular mortality. Results should be interpreted with caution due to the potential for residual confounding in this exploratory analysis. Further studies, specifically designed to test the association between pioglitazone use and patient-focused outcomes, are suggested (BMJ)
Fasting Glucose and All-Cause Mortality by Age in Diabetes: A Prospective Cohort Study
Optimal fasting glucose range for survival is higher in adults with than without known prevalent diabetes, except, perhaps, younger adults. Tight glucose control may lessen premature death in younger adults with diabetes. Hypoglycemia (<65 mg/dL) was associated with higher mortality than was fasting glucose 170–199 mg/dL, while fasting glucose 65–84 mg/dL had risks comparable with those at levels 140–169 mg/dL in diabetes (Diabetes Care)
Diabetes Is Not Associated With Increased 90-Day Mortality Risk in Critically Ill Patients With Sepsis
In the current retrospective large database review, diabetes was not associated with adjusted 90-day mortality risk in critically ill patients admitted with sepsis (Critical Care Medicine)
National Diabetes Audit, 2015-16 Report 2: Complications and Mortality
This report from the National Diabetes Audit (NDA) covers complications of diabetes. It does not include diabetic eye disease or hypoglycaemia because presently there are no reliable records of these that the NDA can access. Most other cardiovascular and diabetes specific complications are included Download (HQIP)
Inpatient screening for albuminuria and retinopathy to predict long-term mortality in type 2 diabetic patients
Albuminuria in type 2 diabetic inpatients is a strong predictor of long-term mortality after discharge from the hospital. Retinopathy is an independent predictor of mortality in type 2 diabetic inpatients without albuminuria but not in those with albuminuria. A low eGFR is a better predictor of mortality than retinopathy in type 2 diabetic inpatients with albuminuria (Diabetology & Metabolic Syndrome)
Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes
In Sweden from 1998 through 2014, mortality and the incidence of cardiovascular outcomes declined substantially among persons with diabetes, although fatal outcomes declined less among those with type 2 diabetes than among controls (NEJM)
Examining Trends in Type 2 Diabetes Incidence, Prevalence and Mortality in the UK between 2004 and 2014
The rising UK prevalence of type 2 diabetes over the last decade is likely to be explained by patients living longer rather than increasing type 2 diabetes incidence (Diabetes, Obesity and Metabolism)
Hemoglobin A1c and Mortality in Older Adults With and Without Diabetes: Results From the National Health and Nutrition Examination Surveys (1988–2011)
An HbA1c >8.0% was associated with increased risk of all-cause and cause-specific mortality in older adults with diabetes. Our results support the idea that better glycemic control is important for reducing mortality; however, in light of the conflicting evidence base, there is also a need for individualized glycemic targets for older adults with diabetes depending on their demographics, duration of diabetes, and existing comorbidities (Diabetes Care)
Nonlinear association of BMI with all-cause and cardiovascular mortality in type 2 diabetes mellitus
In type 2 diabetes, BMI is nonlinearly associated with all-cause mortality with lowest risk in the overweight group in both men and women. Further research is needed to clarify the relationship with cardiovascular mortality and assess causality and sex differences (Diabetologia)
Weight change after initiation of oral hypoglycemic monotherapy for diabetes predicts 5-year mortality: an observational study
Weight loss was associated with higher odds of 5-year mortality among patients initiating an OHA, as was weight gain for metformin only (Diabetes Research and Clinical Practice)
Cardiovascular events and all-cause mortality associated with sulfonylureas compared to other antihyperglycaemic drugs
This meta-analysis shows an association between sulfonylurea therapy and a higher risk of major cardiovascular disease-related events compared to other antihyperglycaemic drugs (Diabetes, Obesity and Metabolism)
BMI at Age 17 Years and Diabetes Mortality in Midlife: A Nationwide Cohort of 2.3 Million Adolescents
Adolescent BMI, including values within the currently accepted “normal” range, strongly predicts DM mortality up to the seventh decade (Diabetes Care)
Identifying Causes for Excess Mortality in Patients With Diabetes: Closer but Not There Yet
Thus, despite advances in the treatment of diabetes, there still appears to be a persistent excess risk of mortality among this population (Diabetes Care)
Body Mass Index at Age 17 and Diabetes Mortality in Midlife: A Nationwide Cohort of 2.3 Million Adolescents
Adolescent BMI, including values within the currently accepted “normal” range, strongly predicts DM mortality up to the seventh decade. The increasing prevalence of childhood and adolescent overweight and obesity points to a substantially increased future adult DM burden (Diabetes Care)
Trends in type 2 diabetes incidence and mortality in Scotland between 2004 and 2013
Incidence of type 2 diabetes has stabilised in recent years suggesting that increasing prevalence may be primarily attributed to declining mortality. Prevention of type 2 diabetes remains important, particularly among socioeconomically deprived populations (Diabetologia)
Obesity and Life Expectancy with and without Diabetes in Adults Aged 55 Years and Older in the Netherlands
Obesity in the middle aged and elderly is associated with a reduction in the number of years lived free of diabetes and an increase in the number of years lived with diabetes. Those extra years lived with morbidity might place a high toll on individuals and health care systems (PLoS Medicine)
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