Women with prior GDM have glucose and lipid metabolism disorders in the 1st trimester. Limited reduction of GWG before oral glucose tolerance test (OGTT) was insufficient to offset the adverse effects of glucose and lipid metabolism disorders in women with previous GDM (Diabetology & Metabolic Syndrome)
Diabetes News
Tag: OGTT
A systematic review on costs and cost-effectiveness of screening and prevention of type 2 diabetes in women with prior gestational diabetes: exploring uncharted territory
An oral glucose tolerance test per three years leads to the lowest cost per case detected, and prevention is potentially cost-effective or cost-saving. More health economic evaluations are needed that compare all relevant alternatives, including ‘doing nothing’ (Diabetes Research and Clinical Practice)
The shape of the glucose concentration curve during an oral glucose tolerance test predicts risk for type 1 diabetes
Those with biphasic glucose curves have a lower risk of progression to type 1 diabetes than those with monophasic curves, and the risk among the monophasic group is increased when the glucose peak occurs at 90 min than at 30 min. Differences in glucose curve shapes between the monophasic and biphasic groups appear to be related to C-peptide responses (Diabetologia)
Screening for diabetes prevention with diabetes risk scores – A balancing act
A blood test post non-invasive risk assessment is a worthwhile step in the process of enrolling participants in a diabetes prevention program. Nevertheless, there will be ineligible individuals who proceed to diabetes (Diabetes Research and Clinical Practice)
One-hour post-load hyperglycemia combined with HbA1c identifies pre-diabetic individuals with a higher cardio-metabolic risk burden
Hyperglycemia at 1-hour during an OGTT may be a useful tool to identify a subset of individuals within HbA1c-defined glycemic categories at higher risk of developing type 2 diabetes and cardiovascular disease (Atherosclerosis)
Early diabetes screening in women with previous gestational diabetes: a new insight
OGTT performed early in postpartum is a useful tool for identifying women with previous GDM who must perform an OGTT 6 weeks after delivery (Diabetology & Metabolic Syndrome)
Delayed insulin secretion response during an OGTT is associated with an increased risk for incidence of diabetes in NGT subjects
NGT subjects with late insulin responses had defective early insulin secretion and were at higher risk of developing diabetes. Insulin secretion patterns could be a useful T2D predictor in the Chinese population (Journal of Diabetes and Its Complications)
One–hour post–load plasma glucose level during the OGTT predicts mortality: observations from the Israel Study of Glucose Intolerance, Obesity and Hypertension
A 1 h glucose value > 155 mg/dl predicts mortality even when the 2 h level is < 140 mg/dl. However, when the 2 h level is in the impaired glucose tolerance range, the hazard for mortality rises significantly independent of the 1 h value. Individuals at risk for developing diabetes could be identified earlier using the 1 h threshold value of 155 mg/dl, which could avert progression to diabetes and increased mortality (Diabetic Medicine)
Women with a history of gestational diabetes on long-term follow up have normal vascular function despite more dysglycemia, dyslipidemia and adiposity
Despite a higher incidence of adiposity, dyslipidemia, and impaired glycemia, women with a history of GDM who had a normal postpartum OGTT did not have impaired vascular function 4 to 10 years postpartum, when compared to healthy controls (Diabetes Research and Clinical Practice)
Smoking affects the oral glucose tolerance test profile and the relationship between glucose and HbA1c in gestational diabetes mellitus
In women with gestational diabetes mellitus who smoke at the beginning of pregnancy, the shape of the OGTT is consistent with accelerated glucose absorption, and HbA1c is higher than expected for glycaemic values (Diabetic Medicine)
Changing the protocol for gestational diabetes mellitus screening
While early testing with OGTT for high-risk women may be helpful, the value of early testing with random BGL for low-risk women is questionable. The new ADIPS criteria are likely to increase the number of women diagnosed with GDM (with an emphasis on earlier diagnosis), but the absolute increase remains small (Australian and New Zealand Journal of Obstetrics and Gynaecology)
The Discordance between HbA1c and Glucose Tolerance Testing for the Postpartum Exclusion of Diabetes following Gestational Diabetes
In the post-GDM population, the HbA1c misses cases of diabetes as identified by the OGTT. We recommend that the OGTT be retained for postpartum diabetes testing following GDM (Diabetes Research and Clinical Practice)
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