Oral insulin (ORMD-0801) induced greater reductions in HbA1c when compared to placebo and was safe and well-tolerated in individuals with uncontrolled T2DM (Institute of Endocrinology, Metabolism & Hypertension )
Diabetes News
Tag: oral insulin
Safety and Efficacy of an Oral Insulin (Capsulin) in Patients with Early-Stage Type 2 Diabetes: A Dose-Ranging Phase IIb Study
Capsulin oral insulin administered twice per day at a dose of 150iu per capsule is safe, with no confirmed treatment-linked hypoglycaemic events, and results in significant decreases from baseline in HbA1c, Fasting Plasma Glucose and triglycerides (Diabetes, Obesity and Metabolism)
Efficacy and safety of 28-day treatment with oral insulin (ORMD-0801) in patients with type 2 diabetes mellitus – A randomized placebo-controlled trial
In patients with T2DM, bedtime ORMD-0801 curbed increases in night-time glycemia, 24-hour glycemia and HbA1c, without increasing risk of hypoglycaemia, or safety events as compared to the control arm (Diabetes, Obesity and Metabolism)
Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double-blind, phase 2 trial
I338 can safely improve glycaemic control in insulin-naive patients with type 2 diabetes with no evidence of a difference compared with insulin glargine, a widely used subcutaneously administered basal insulin (The Lancet Diabetes & Endocrinology)
Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double-blind, phase 2 trial
I338 can safely improve glycaemic control in insulin-naive patients with type 2 diabetes with no evidence of a difference compared with insulin glargine, a widely used subcutaneously administered basal insulin. Further development of this particular oral insulin project was discontinued because I338 doses were high and, therefore, production of the required quantities of I338 for wide public use was deemed not commercially viable. Improvement of technologies involved in the product’s development is the focus of ongoing research
Efficacy and safety of oral insulin compared to subcutaneous insulin: a systematic review and meta-analysis
This systematic review and meta-analysis showed that oral insulin is comparable to SC insulin with regard to glycemic efficacy and safety. However, it is necessary to conduct additional studies in which oral insulin administered to large number of patients for long enough periods of time (Journal of Endocrinological Investigation)
Glycosmedia is also available as an App: