In this issue of JAMA, the US Preventive Services Task Force (USPSTF) addresses this important issue with a new Recommendation Statement on screening for prediabetes and type 2 diabetes in children and adolescents based on an Evidence Report and Systematic Review of the evidence on screening for prediabetes and type 2 diabetes in asymptomatic, nonpregnant persons younger than 18 year (JAMA)
Diabetes News
Tag: prediabetes
Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies
Prediabetes was positively associated with risk of all-cause mortality and the incidence of cardiovascular outcomes, CHD, stroke, chronic kidney disease, cancer and dementia (Diabetologia)
Impact of prediabetes on long-term cardiovascular outcomes in patients with myocardial infarction with nonobstructive coronary arteries
Pre-DM defined as raised HbA1c was associated with a poor prognosis in patients with MINOCA. Routine assessment of HbA1c enables an early recognition of pre-DM and thus may facilitate risk stratification in this specific population (Diabetology & Metabolic Syndrome)
Prediabetes and risk of heart failure: the link grows stronger
This study provides important evidence that the risk of heart failure is increased in people with a fasting plasma glucose concentration as low as 100 mg/dL, supporting the definition of prediabetes according to the American Diabetes Association guideline (Cardiovascular Diabetology)
Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study
Our findings show that women with type 2 diabetes are not disproportionately affected by early microvascular complications (Cardiovascular Diabetology)
The prevalence of cardiac autonomic neuropathy in prediabetes: a systematic review
There is a higher than expected prevalence of CAN in prediabetes. Early detection of CAN in prediabetes through population screening needs careful consideration in view of the excess morbidity and mortality risk associated with this condition (Diabetologia)
An increase in inflammation and islet dysfunction is a feature of prediabetes
Based on our findings, inflammation and islet dysfunction may be more significant than originally thought in people with prediabetes. Rather than being in a normal state before diabetes occurs, it appears they are already in an early diabetic condition more closely resembling T2D (Diabetes/Metabolism Research and Reviews)
Long-term Sustainability of Diabetes Prevention Approaches
In adults at risk for diabetes, LSM and medications (weight loss and insulin-sensitizing agents) successfully reduced diabetes incidence. Medication effects were short lived. The LSM interventions were sustained for several years; however, their effects declined with time, suggesting that interventions to preserve effects are needed (JAMA)
Women with prior gestational diabetes mellitus and prediabetes are characterised by a decreased incretin effect
Prediabetes was highly prevalent in women with pGDM, and alterations in the incretin effect were detected in this group before the development of type 2 diabetes (diabetologia)
Examining trends in prediabetes and its relationship with the metabolic syndrome in US adolescents, 1999–2014
We found conflicting findings of temporal trends of US adolescent prediabetes prevalence based on the ADA’s prediabetes criteria. The increasing prevalence of prediabetes by HbA1c assessment is concerning and raises the urgency for increased awareness and appropriate measures of prediabetes status among physicians and patients (Acta Diabetologica)
Mixed methods study of engagement in behaviors to prevent type 2 diabetes among employees with pre-diabetes
Most employees found to have pre-diabetes through a workplace screening were engaged in a recommended preventive behavior 3 months after the screening. This engagement could be enhanced by optimizing motivation and risk perception as well as leveraging social networks and external supports (BMJ)
Insulin Resistance and Metabolic Syndrome in Young Men With Acne
Postadolescent male patients with acne more commonly have insulin resistance. This resistance may be a stage of prediabetes, and the patients may develop hyperinsulinemia or type 2 diabetes in the future. These patients should be followed up for a prolonged time to determine whether they develop conditions associated with insulin resistance (JAMA Dermatology)
Design of stepwise screening for prediabetes and type 2 diabetes based on costs and cases detected
Our applied method makes it possible to identify a range of efficient cut-offs where higher detection rates can be achieved at an additional cost per detected patient. This enables decision makers to choose an optimal cut-off based on their willingness to pay for additional detected patients (Journal of Clinical Endocrinology Epidemiology)
US initiative for prediabetes
Health officials in the USA want physicians to help to reduce diabetes by asking at-risk patients to join diabetes prevention programmes. Susan Jaffe reports from Washington, DC (The Lancet Diabetes & Endocrinology)
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