Recent studies have found that SGLT2 is also expressed in the human retina. Now, the prevention and treatment of diabetic retinopathy with SGLT2i while reducing blood sugar has become a new research field. Hence, this article reviewed the recent therapeutic and research progress of SGLT2 in the treatment of diabetic retinopathy (Journal of Diabetes Research)
Diabetes News
Tag: retinopathy
Different retinopathy phenotypes in type 2 diabetes predict retinopathy progression
Different DR phenotypes in type 2 diabetes show different risks of retinopathy progression. Phenotype C is associated with increased HbA1c values and presents a higher risk of a 2-or-more-step worsening of the ETDRS severity score (Acta Diabetologica)
Progression of Diabetic Retinopathy and Declining Renal Function in Patients with Type 2 Diabetes
Declining renal function was independently associated with DR progression in patients with NPDR, suggesting that investigation of DR status should be recommended for patients with declining renal function (Journal of Diabetes Research)
IDF Diabetes Atlas: A review of studies utilising retinal photography on the global prevalence of diabetes related retinopathy between 2015 and 2018
This study illustrated difficulties in deriving a meaningful global prevalence rate for DR and DME due to the lack of uniformity in defining the study populations, methodological differences, retinal image capture and grading criteria. Therefore, international consensus is required using a minimal data set for future studies (Diabetes Research and Clinical Practice)
Vulnerabilities in diabetic eye screening for children and young people in England
There is limited direct communication between the services involved in diabetic eye care for CYP in England. This risks reducing the effectiveness of diabetic retinopathy screening. Similar vulnerabilities are likely to exist in other countries where retinopathy screening for CYP has been ‘bolted on’ to provision for adults (Pediatric Research)
Discordance in risk factors for the progression of diabetic retinopathy and diabetic nephropathy in patients with type 2 diabetes mellitus
Average glycemia was significantly associated with progression of DR, whereas glycemic variability and dyslipidemia were significantly associated with progression of DN in type 2 diabetes mellitus (Journal of Diabetes Investigation)
The prevalence of retinopathy in patients with type 1 diabetes treated with education-based intensified insulin therapy and its association with parameters of glucose control
In type 1 diabetes EBIIT is associated with good diabetes control and a low prevalence of DR. The cumulative glucose exposure over time given as HbA1c years is the best predictor for development of DR (Diabetes Research and Clinical Practice)
Applicability of telemedicine in the screening of diabetic retinopathy (DR): The first multicentre study in Italy. The No Blind Study
Our findings, in an Italian setting, confirm main data in the literature about DR prevalence. Hence, telemedicine could represent an accurate, fast and cheap method for screening of DR (Diabetes/Metabolism Research and Reviews)
Glycaemic variability assessed by continuous glucose monitoring and the risk of diabetic retinopathy in latent autoimmune diabetes of the adult and type 2 diabetes
GV is more strongly associated with DR in type 2 diabetes than in LADA, suggesting that different glucose‐lowering strategies should be adopted for these two types of diabetes (Journal of Diabetes Investigation)
Association between diabetic eye disease and other complications of diabetes: implications for care. A systematic review
This analysis highlights the need for a coordinated and collaborative approach to patient management. Given the widespread use of DR screening programs that can be performed outside of an ophthalmology office, and the overall cost‐effectiveness of DR screening, the presence and severity of DR can act as a means of identifying patients at increased risk for micro‐ and macro‐vascular complications, enabling earlier detection, referral, and intervention with the aim of reducing morbidity and mortality among patients with diabetes (Diabetes, Obesity and Metabolism)
Global perspectives on the provision of diabetic retinopathy screening and treatment: Survey of health care professionals in 41 countries
Health care professionals need to be appropriately supported and trained so they can provide adults with diabetes with information about the risks of DR, support them in reducing their risk, and advocate for the provision of affordable DR screening and treatment as required (Diabetes Research and Clinical Practice)
Lipid‐lowering medication is associated with decreased risk of diabetic retinopathy and the need for treatment in patients with type 2 diabetes
In a population of patients with type 2 diabetes with a variety of risk profiles, use of lipid‐lowering medication reduced the risk of DR and thus the risks involved in treatment with laser photocoagulation and vitrectomy (Diabetes, Obesity and Metabolism)
Association of Metformin Treatment with Reduced Severity of Diabetic Retinopathy in Type 2 Diabetic Patients
Long-term use of metformin is independently associated with a significant lower rate of SNPDR/PDR in patients with type 2 diabetes ≥ 15 years (Journal of Diabetes Research)
Association of Abnormal Renal Profiles and Proliferative Diabetic Retinopathy and Diabetic Macular Edema in an Asian Population With Type 2 Diabetes
Abnormal renal profiles at baseline, including a high serum creatinine level, low estimated glomerular filtration rate, and high urinary ACR, were associated with the development of PDR in patients with type 2 diabetes (JAMA Ophthalmology)
The UK Diabetic Retinopathy Electronic Medical Record (UK DR EMR) Users Group, Report 2: real-world data for the impact of cataract surgery on diabetic macular oedema
This large real-world study demonstrates that the rate of developing treatment-requiring DMO increases sharply in the year after cataract surgery for all grades of retinopathy, peaking in the 3–6 months’ postoperative period. Patients with moderate and severe NPDR are at particularly high risk (British Journal of Ophthalmology)
Mechanism of worsening diabetic retinopathy with rapid lowering of blood glucose: the synergistic hypothesis
We postulate that exogenous insulin could act synergistically with the vascular endothelial growth factor expressed by ischemic retina so as to trigger vascular proliferation and the worsening of diabetes retinopathy (BMC Endocrine Disorders)
Insulin resistance correlates with maculopathy and severity of retinopathy in young adults with Type 1 Diabetes Mellitus
IR correlates with more severe retinopathy in young adults with Type 1 DM. This is the first description of a correlation between IR and maculopathy in Type 1 DM, warranting further evaluation. Prospective studies examining whether reducing IR can improve microvascular complications are required (Diabetes Research and Clinical Practice)
Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks
Patients with proliferative diabetic retinopathy who were treated with intravitreal aflibercept had an improved outcome at 1 year compared with those treated with PRP standard care (Lancet)
Frequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes
Our model for establishing an individualized schedule for retinopathy screening on the basis of the patient’s current state of retinopathy and glycated hemoglobin level reduced the frequency of eye examinations without delaying the diagnosis of clinically significant disease (NEJM)
The English National Screening Programme for diabetic retinopathy 2003–2016
The benefit of the programme is that, in England, diabetic retinopathy/maculopathy is no longer the leading cause of certifiable blindness in the working age group (Acta Diabetologica)
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