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Diabetes News

Tag: statin


Statin use is associated with lower prevalence of advanced liver fibrosis in patients with type 2 diabetes

March 14th 2021

Given the absence of approved therapies for NAFLD-fibrosis, it would be reasonable to initiate specific randomized controlled trials with statins (Metabolism – Clinical and Experimental)

Categories: Hepatology, News
Tags: statin, Type 2 Diabetes

Categories: Hepatology
Tags: statin, Type 2 Diabetes

Increased Residual Cardiovascular Risk in Patients with Diabetes and High vs. Normal Triglycerides Despite Statin‐Controlled LDL Cholesterol

September 20th 2018

Despite statin‐controlled LDL‐C levels, CV events were greater among patients with diabetes and high TG levels. Because we controlled for cardiometabolic risk factors, it is likely that the difference in TG levels contributed to the excess risk observed in patients with high TGs (Diabetes, Obesity and Metabolism)

Categories: Cardiovascular, News
Tags: LDL‐C, statin, triglycerides

Categories: Cardiovascular
Tags: LDL‐C, statin, triglycerides

Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy

July 1st 2018

More studies of combined Metformin–statin treatment in patients are necessary to explain the effects of different Metformin–statin doses on the glucose and lipid metabolism, in different stages of progression of diabetes and/or dyslipidemia, in more detail (Cardiovascular Diabetology)

Categories: Medication, News
Tags: metformin, statin, Type 2 Diabetes

Categories: Medication
Tags: metformin, statin, Type 2 Diabetes

Liver Safety of Statins in Prediabetes or T2DM and Nonalcoholic Steatohepatitis: Post Hoc Analysis of a Randomized Trial

December 12th 2017

Statin therapy is safe in patients with prediabetes/T2DM and NASH. Given their high cardiovascular risk, statin therapy should be encouraged in this population (JCEM)

Categories: Hepatology, News
Tags: NASH, statin, Type 2 Diabetes

Categories: Hepatology
Tags: NASH, statin, Type 2 Diabetes

Statin Use for the Primary Prevention of Cardiovascular Disease in Adults

November 14th 2016

The USPSTF recommends initiating use of low- to moderate-dose statins in adults aged 40 to 75 years without a history of CVD who have 1 or more CVD risk factors (dyslipidemia, diabetes, hypertension, or smoking) and a calculated 10-year CVD event risk of 10% or greater (JAMA)

Categories: Cardiovascular, News
Tags: statin

Categories: Cardiovascular
Tags: statin

Use of statins offsets insulin-related cancer risk

November 8th 2016

The use of statins offsets insulin-related cancer risks in patients with diabetes independently of sex and age (Journal of Internal Medicine)

Categories: Medication, News
Tags: cancer, statin

Categories: Medication
Tags: cancer, statin

Moderate-intensity statin therapy seems ineffective in primary cardiovascular prevention in patients with type 2 diabetes complicated by nephropathy. A multicenter prospective 8 years follow up study

October 14th 2016

These findings suggest that, in a real clinical setting, moderate-intensity statin treatment is ineffective in cardiovascular primary prevention for patients with diabetic nephropathy (Cardiovascular Diabetology)

Categories: Cardiovascular, News
Tags: statin, Type 2 Diabetes

Categories: Cardiovascular
Tags: statin, Type 2 Diabetes

Interpretation of the evidence for the efficacy and safety of statin therapy

September 9th 2016

This Review is intended to help clinicians, patients, and the public make informed decisions about statin therapy for the prevention of heart attacks and strokes (Lancet)

Categories: Medication, News
Tags: statin

Categories: Medication
Tags: statin

Statins for people with type 1 diabetes: when should treatment start?

February 10th 2016

A large evidence base supports the use of statins in people with type 2 diabetes, but there is very limited evidence for the use of statins in people with type 1 diabetes. Cardiovascular expert, Miles Fisher examines the confusion and contradictory recommendations from major guidelines, highlights the lack of new data and suggests a pragmatic approach based upon the existing research (Practical Diabetes)

Categories: Medication, News
Tags: statin, Type 1 Diabetes

Categories: Medication
Tags: statin, Type 1 Diabetes

Intensity of statin therapy and new hospitalizations for heart failure in patients with type 2 diabetes

October 29th 2015

In type 2 diabetes, moderate-intensity statins, in comparison to low-intensity or no statin, were associated with lower HF incidence independently of LDL levels or of CAD events (BMJ)

Categories: Cardiovascular, News
Tags: heart failure, statin

Categories: Cardiovascular
Tags: heart failure, statin

Statins are Independently Associated with Increased HbA1c in Type 1 Diabetes–The Thousand & 1 Study

October 22nd 2015

In T1DM, use of statins is independently associated with impaired glycemic control. A causal relationship cannot be determined from this study. Given the benefit on cardiovascular outcome, this should not cause patients to stop statin treatment, but may indicate a need to revisit dose of insulin when starting statin treatment (Diabetes Research and Clinical Practice)

Categories: Medication, News
Tags: HbA1c, statin, Type 1 Diabetes

Categories: Medication
Tags: HbA1c, statin, Type 1 Diabetes

Statins and the Risk of Pancreatic Cancer in Type 2 Diabetic Patients – A Population-Based Cohort Study

August 25th 2015

Statin use may be associated with a reduced risk of pancreatic cancer in type 2 diabetic patients. More research is needed to clarify this association (International Journal of Cancer)

Categories: Medication, News
Tags: pancreatic cancer, statin, Type 2 Diabetes

Categories: Medication
Tags: pancreatic cancer, statin, Type 2 Diabetes

Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

June 8th 2015

When added to statin therapy, Ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit (NEJM)

Categories: Medication, News
Tags: Ezetimibe, statin

Categories: Medication
Tags: Ezetimibe, statin

Primary prevention with lipid lowering drugs and long term risk of vascular events in older people: population based cohort study

May 19th 2015

In a population based cohort of older people with no history of vascular events, use of statins or fibrates was associated with a 30% decrease in the incidence of stroke (BMJ)

Categories: News, Treatment
Tags: statin

Categories: Treatment
Tags: statin

Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort

April 13th 2015

Statin treatment increased the risk of type 2 diabetes by 46%, attributable to decreases in insulin sensitivity and insulin secretion (Diabetologia)

Categories: Medication, News
Tags: statin

Categories: Medication
Tags: statin

Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events

March 17th 2015

Over a period of 78 weeks, alirocumab, when added to statin therapy at the maximum tolerated dose, significantly reduced LDL cholesterol levels. In a post hoc analysis, there was evidence of a reduction in the rate of cardiovascular events with alirocumab (NEJM)

Categories: Medication, News
Tags: alirocumab, LDL cholesterol, statin

Categories: Medication
Tags: alirocumab, LDL cholesterol, statin

Renal effects of atorvastatin and rosuvastatin in patients with diabetes who have progressive renal disease (PLANET I)

February 4th 2015

Despite high-dose rosuvastatin lowering plasma lipid concentrations to a greater extent than did high-dose atorvastatin, atorvastatin seems to have more renoprotective effects for the studied chronic kidney disease population (The Lancet Diabetes & Endocrinology)

Categories: Nephrology, News
Tags: atorvastatin, statin

Categories: Nephrology
Tags: atorvastatin, statin

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