We provided the first evidence that CD34+ HSPC express GLP-1R and that LIRA can favorably impact on cell dysfunction due to HG exposure. These findings open new perspectives on the favorable CV effects of GLP-1 RAs in T2DM patients (Cardiovascular Diabetology)
Diabetes News
Tag: stem cells
Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche
We found PDX1+/ALK3+/CAII− progenitor-like cells in the MPDs of types 1 and 2 diabetes donors, regardless of the duration of the disease. Our findings open the door to the pharmacological activation of progenitor cells in situ (PNAS)
Generation of stem cell-derived β-cells from patients with type 1 diabetes
These results show that T1D SC-β cells could potentially be used for the treatment of diabetes, drug screening and the study of β-cell biology (Nature)
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