Position statement of the European Association for the Study of Diabetes (EASD) and of the International Society for Pediatric and Adolescent Diabetes (ISPAD) endorsed by JDRF and supported by the American Diabetes Association (Diabetologia)
Diabetes News
Tag: Type 1 Diabetes
Potential Benefits and Harms of Gastric Bypass Surgery in Obese Individuals With Type 1 Diabetes
This observational study suggests bariatric surgery may yield similar benefits on risk for cardiovascular outcomes and mortality in patients with T1D and obesity as for patients with type 2 diabetes (Diabetes Care)
Next steps in the identification of gene targets for type 1 diabetes
The purpose of this review is to provide a view of the future of genomics and other omics approaches in defining the genetic contribution to all stages of risk of type 1 diabetes and the functional impact and clinical implementations of the associated variants (Diabetologia)
Relationship of glycemic derangement using continuous glucose monitoring system with sleep pattern among children with type 1 diabetes mellitus
Clinically significant hypoglycemia is associated with sleep deepening, while hyperglycemia is associated with increased light sleep, sleep onset latency, AI among C‐T1D (Diabetes/Metabolism Research and Reviews)
Prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with type 1 diabetes mellitus: a systematic review and meta-analysis
NAFLD prevalence in patients with type 1 diabetes is considerable and is highly dependent on the specific diagnostic modality and NAFLD definition used. These data are helpful in directing actions to standardize NAFLD diagnosis, which will help defining contributing mechanisms and outcomes (Journal of Clinical Endocrinology & Metabolism)
Dietary strategies to manage diabetes and glycemic control in youth and young adults with youth‐onset type 1 and type 2 diabetes
For several dietary strategies, more frequent use over time was related to lower A1c in youth‐onset type 1 and type 2 diabetes, suggesting these strategies can likely support diabetes management for this population (Pediatric Diabetes)
Diabetes distress and HbA1c in racially/ethnically and socioeconomically diverse youth with type 1 diabetes
Diabetes distress is elevated in a younger population of children with T1D who are from racial/ethnic minority backgroundsor have markers of lower SES (Pediatric Diabetes)
Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study
Deaths in people with type 1 and type 2 diabetes rose sharply during the initial COVID-19 pandemic in England. Increased COVID-19-related mortality was associated not only with cardiovascular and renal complications of diabetes but, independently, also with glycaemic control and BMI (The Lancet Diabetes & Endocrinology)
Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study
The results of this nationwide analysis in England show that type 1 and type 2 diabetes were both independently associated with a significant increased odds of in-hospital death with COVID-19 (The Lancet Diabetes & Endocrinology)
Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes
In this young population with T1D and high rates of hyperfiltration, osteopontin was the most consistent biomarker associated with prospective changes in eGFR. FGF‐23 was associated with eGFR increases, whereas TF‐3, cystatin C and B2M were only associated with baseline eGFR (Pediatric Diabetes)
Efficacy of GAD-alum immunotherapy associated with HLA-DR3-DQ2 in recently diagnosed type 1 diabetes
GAD65-specific immunotherapy has a significant effect on C-peptide retention in individuals with recent-onset type 1 diabetes who have the DR3-DQ2 haplotype (Diabetologia)
Bone mineral density spectrum in individuals with type 1 diabetes, LADA , and type 2 diabetes
BMD values in T1D, LADA and T2D were in an increasing order of mention. Patients with autoimmune diabetes were more susceptible to osteoporosis. A lower C‐peptide level may be responsible for decreased BMD in individuals with autoimmune diabetes (Diabetes/Metabolism Research and Reviews)
Compatibility and Safety of Ultra Rapid Lispro with Continuous Subcutaneous Insulin Infusion in Patients with Type 1 Diabetes: PRONTO-Pump Study
URLi was compatible with insulin pump use with a safety profile similar to lispro (Diabetes Technology and Therapeutics)
Risk factors for hospitalization in youth with type 1 diabetes: Development and validation of a multivariable prediction model
Our multivariable prediction model identified patients at increased risk of admission in the 12 months following assessment (Pediatric Diabetes)
The Association Between HbA1c and Time in Hypoglycemia During CGM and Self-Monitoring of Blood Glucose in People With Type 1 Diabetes and Multiple Daily Insulin Injections
CGM is associated with considerably less time in hypoglycemia than SMBG at a broad range of HbA1c levels and is crucial for patients with MDI treatment if they are to have a chance to approach hypoglycemia targets (Diabetes Care)
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes
Our study provides robust histological evidence that a clinical diagnostic model, combining clinical features and biomarkers, could improve diabetes classification. Our study also provides reassurance that a C‐peptide‐based definition of type 1 diabetes is an appropriate surrogate outcome that can be used in large clinical studies where histological definition is impossible (Diabetic Medicine)
Sotagliflozin added to optimised insulin therapy leads to HbA1c reduction without weight gain in adults with type 1 diabetes
When added to optimised insulin therapy, sotagliflozin improved glycaemic control and body weight and enabled more adults with T1D to achieve A1c goals without weight gain over 52 weeks, although there was more DKA relative to placebo (Diabetes, Obesity and Metabolism)
Exenatide ER in patients with Type 1 diabetes with and without residual insulin production
Treatment with exenatide ER may have short‐term benefits in some individuals with T1D who are overweight or with detectable levels of C‐peptide, but short term improvements were not sustained (Diabetes, Obesity and Metabolism)
COVID-19 and Type 1 Diabetes: Challenges and actions
The authors of this commentary are involved in the care of T1D in LMICs and see services in such settings suffering in three major ways from the impacts of COVID-19 (Diabetes Research and Clinical Practice)
Effect of Continuous Glucose Monitoring on Hypoglycemia in Older Adults With Type 1 Diabetes
Among adults aged 60 years or older with type 1 diabetes, continuous glucose monitoring compared with standard blood glucose monitoring resulted in a small but statistically significant improvement in hypoglycemia over 6 months (JAMA)
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