A hybrid closed-loop system significantly improved glycemic control in very young children with type 1 diabetes, without increasing the time spent in hypoglycemia (NEJM)
Diabetes News
Tag: Type 1 Diabetes
Characterising the age-dependent effects of risk factors on type 1 diabetes progression
Analysing the age-varying effect of disease predictors improves understanding and prediction of type 1 diabetes disease progression, and should be leveraged to refine prediction models and guide mechanistic studies (Diabetologia)
Randomized controlled study to evaluate the impact of flexible patient-controlled visits in people with type 1 diabetes: The DiabetesFlex Trial
Compared with standard care, flexible patient-controlled visits combined with patient-reported outcomes in participants with metabolic controlled type 1 diabetes and good psychological well-being further improved diabetes-related well-being and decreased face-to-face visits while maintaining safe diabetes management (Diabetic Medicine)
A Practical Approach to Continuous Glucose Monitoring (rtCGM) and FreeStyle Libre systems (isCGM) in Children and Young people with Type 1 Diabetes
This article, aims to provide a practical approach and help identify which patients may be most likely to benefit and how the technology may be implemented in order to maximise the clinical benefits (Diabetes Research and Clinical Practice)
Comparisons of biochemical parameters and diabetic ketoacidosis severity in adult patients with type 1 and type 2 diabetes
There are no differences in DKA-related biochemical parameters between type 1 and type 2 diabetes patients. The present findings suggest that DKA should be assessed and treated similarly, regardless of its occurrence in type 1 or type 2 diabetes patients (BMC Endocrine Disorders)
How low is really low? Comparison of two C-peptide assays to establish residual C-peptide production in type 1 diabetes
The IRMA provided the lowest threshold for quantification of serum C-peptide. LoQ of commercially available assays should be established in-house before applying them in research studies and clinical trials in which low C-peptide levels have clinical or scientific relevance (Diabetic Medicine)
Standards of Medical Care in Diabetes—2022
Professional Practice Committee: Standards of Medical Care in Diabetes—2022 (Diabetes Care)
The Role of Glucagon in Glycemic Variability in Type 1 Diabetes: A Narrative Review
There is growing evidences to illustrate the contribution of glucagon secretion to the glycemic variability in patients with T1DM, which may promote the development of new treatment strategies aiming to mitigate glycemic variability associated with aberrant glucagon secretion (Metabolic Syndrome and Obesity)
Current provision and HCP experiences of remote care delivery and diabetes technology training for people with type 1 diabetes in the UK during the Covid-19 pandemic
This survey highlights UK health care professionals experiences of remote care delivery. Whilst supportive of virtual care models, a number of factors highlighted, especially patient digital literacy, need to be addressed to improve virtual care delivery and device training (Diabetic Medicine)
Impact of COVID-19 Vaccination on Glycemia in Individuals With Type 1 and Type 2 Diabetes: Substudy of the COVAC-DM Study
Our data revealed that COVID-19 vaccination per se did not change glycemic control in people with diabetes. Of note, on days on which side effects were present, a deterioration of glycemia was observed in people with type 1 diabetes (Diabetes Care)
Closed-Loop Insulin Delivery Versus Sensor-Augmented Pump Therapy in Older Adults With Type 1 Diabetes (ORACL): A Randomized, Crossover Trial
Closed-loop therapy is an effective treatment option for older adults with long-duration type 1 diabetes, and no safety issues were identified. These older adults had higher TIR accompanied by less time below range during closed-loop than during sensor-augmented pump therapy. Of particular clinical importance, closed loop reduced the time spent in hypoglycemic range overnight (Diabetes Care)
Classic Type 1 Diabetes Mellitus and Fulminant Type 1 Diabetes Mellitus: Similarity and Discrepancy of Immunological Characteristics and Cytokine Profile
Compared with T1ADM, CRP and leukocytes’ levels were increased significantly in FT1DM, with an increase in neutrophil% and decline in lymphocyte%, suggesting that FT1DM may have more abrupt onset and occur as a more serious subtype of type 1 diabetes mellitus (Diabetes, Metabolic Syndrome and Obesity)
Developing a novel intervention for type 1 diabetes and disordered eating using a participatory action design process: Safe management of people with Type 1 diabetes and EAting Disorders studY (STEADY)
Through an iterative co-design process, people with type 1 diabetes and healthcare professionals collaboratively developed a novel intervention toolkit that can be used with a wide range of disordered eating presentations. The intervention will be tested in the STEADY feasibility randomized controlled trial (Diabetic Medicine)
Type 1 diabetes in adults: diagnosis and management – glucose monitoring and diagnosis
Consultation documents (NICE)
Diabetes (type 1 and type 2) in children and young people: diagnosis and management – glucose monitoring
Consultation documents (NICE)
Type 1 diabetes in adults
Type 1 diabetes in adults – everything NICE says in an interactive flowchart (NICE)
Forxiga (dapagliflozin) 5mg should no longer be used for the treatment of Type 1 Diabetes Mellitus
Effective 25 October 2021 Forxiga (dapagliflozin) 5mg is no longer authorised for the treatment of patients with type 1 diabetes mellitus (T1DM) and should no longer be used in this population. This is based on Astra Zeneca’s decision to remove the T1DM indication for dapagliflozin 5mg download guidance (European Medicines Agency)
Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention
There is a potential to identify both T2D and T1D at stages well before the onset of currently recognized clinical disease (Diabetes)
Renal Complications and Duration of Diabetes: An International Comparison in Persons with Type 1 Diabetes
This analysis used three nationwide registries of persons with T1D. Despite recent use of more effective diabetes therapies, a substantial proportion of persons with T1D have renal complications at < 20 years after diagnosis. Efficient glucose-lowering and renal-protective strategies are needed in persons with T1D (Diabetes Therapy)
A systematic review and meta-analysis of interventions to preserve insulin-secreting beta cell function in people newly diagnosed with type 1 diabetes: results from intervention studies aimed at improving glucose control
This is the largest comprehensive review of RCTs in this area. It demonstrates a lack of robust evidence that interventions to improve glucose control preserve beta cell function in new onset type 1 diabetes, although analysis was hampered by low quality evidence and inconsistent reporting of studies (Diabetic Medicine)
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