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Diabetes News

Tag: Type 1 Diabetes


Empagliflozin add-on therapy to closed-loop insulin delivery in type 1 diabetes: a 2 × 2 factorial randomized crossover trial

May 18th 2022

While no diabetic ketoacidosis or severe hypoglycemia occurred during any intervention, uncomplicated ketosis events were more common on empagliflozin. Empagliflozin 25 mg d−1 added to automated insulin delivery improves glycemic control but increases ketone concentration and ketosis compared to placebo (Nature Medicine)

Categories: Medication, News
Tags: Empagliflozin, Type 1 Diabetes

Categories: Medication
Tags: Empagliflozin, Type 1 Diabetes

Diabetic Bone Disease and Diabetic Myopathy: Manifestations of the Impaired Muscle-Bone Unit in Type 1 Diabetes

May 13th 2022

This review summarizes several nonmechanical factors that could be mediating the development and progression of premature musculoskeletal decline in this population and discusses preventative measures to reduce the burden of diabetes on the musculoskeletal system (Journal of Diabetes Research)

Categories: News, Pathology
Tags: bone disease, myopathy, Type 1 Diabetes

Categories: Pathology
Tags: bone disease, myopathy, Type 1 Diabetes

Incidence rate patterns, cumulative incidence, and time trends for moderate and severe albuminuria in individuals diagnosed with type 1 diabetes aged 0–14 years: a population-based retrospective cohort study

May 12th 2022

Our analyses show that the cumulative incidence of severe albuminuria has decreased between 1970–79 and 1980–99; however, whether this decrease solely denotes a delay in albuminuria, or also a true prevention of albuminuria, needs to be investigated further. Nevertheless, diabetic kidney disease remains a significant complication of type 1 diabetes. Due to the robust association of diabetic kidney disease with premature mortality, novel therapies to improve prognosis are needed (The Lancet Diabetes & Endocrinology)

Categories: Nephropathy, News
Tags: albuminuria, Type 1 Diabetes

Categories: Nephropathy
Tags: albuminuria, Type 1 Diabetes

Addition of intermittently scanned continuous glucose monitoring to standard care in a cohort of pregnant women with type 1 diabetes: effect on glycaemic control and pregnancy outcomes

May 12th 2022

isCGM use provided an initial improvement in glycaemic control that was not sustained. Furthermore, offspring of isCGM users were more likely to have neonatal hypoglycaemia, with similar rates of macrosomia and prematurity to those of women receiving standard care (Diabetologia)

Categories: Gestational, Monitoring, News
Tags: CGM, Type 1 Diabetes

Categories: Gestational, Monitoring
Tags: CGM, Type 1 Diabetes

Differential prognostic burden of cardiovascular disease and lower-limb amputation on the risk of all-cause death in people with long-standing type 1 diabetes

May 10th 2022

CVD and LLA conferred a similar burden regarding mortality in type 1 diabetes population. Our findings encourage a careful consideration of people with type 1 diabetes and LLA as usually recommended for those with CVD, in terms of management of risk factors, treatments and prevention (Cardiovascular Diabetology)

Categories: Cardiovascular, Monitoring, News
Tags: amputation, mortality, Type 1 Diabetes

Categories: Cardiovascular, Monitoring
Tags: amputation, mortality, Type 1 Diabetes

Reductions in HbA1c with Flash Glucose Monitoring Are Sustained for up to 24 Months: A Meta-Analysis of 75 Real-World Observational Studies

April 27th 2022

Meta-analysis of RWE confirms that using the FreeStyle Libre system is associated with significant reductions in HbA1c for adults with T1DM or with T2DM. Reductions are greater for people with higher baseline HbA1c and are sustained for 24 and 12 months in T1DM and TD2M respectively (Diabetes Therapy)

Categories: Monitoring, News
Tags: FreeStyle, HbA1c, Type 1 Diabetes, Type 2 Diabetes

Categories: Monitoring
Tags: FreeStyle, HbA1c, Type 1 Diabetes, Type 2 Diabetes

Biggest-ever philanthropic gift to diabetes research brings Type 1 cure closer

April 26th 2022

An incredible and unprecedented £50 million investment from the Steve Morgan Foundation, the partnership will fund game-changing type 1 diabetes research that will pave the way to the development of new treatments and a cure (Diabetes UK)

Categories: News, Research
Tags: Type 1 Diabetes

Categories: Research
Tags: Type 1 Diabetes

Incident cardiovascular disease by clustering of favourable risk factors in type 1 diabetes: the EURODIAB Prospective Complications Study

April 12th 2022

Low HbA1c and low BP were protective cardiovascular health metrics in our study of people with type 1 diabetes. Targeting all cardiovascular health metrics could be more effective in preventing CVD than targeting single metrics (Diabetologia)

Categories: Cardiovascular, News
Tags: Type 1 Diabetes

Categories: Cardiovascular
Tags: Type 1 Diabetes

Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes

April 11th 2022

Strong differences in sex and age distributions as well as in genetic associations could be observed between GADA- and IAA-initiated autoimmunity (Pediatric Diabetes)

Categories: Genetics, News, Paediatrics, Pathology
Tags: autoantibody, Islet, Type 1 Diabetes

Categories: Genetics, Paediatrics, Pathology
Tags: autoantibody, Islet, Type 1 Diabetes

Type 1 diabetes in adults: diagnosis and management

March 31st 2022

NICE guideline [NG17]Published: 26 August 2015 Last updated: 31 March 2022 (NICE)

Categories: Guidance, News
Tags: NICE, Type 1 Diabetes

Categories: Guidance
Tags: NICE, Type 1 Diabetes

Diabetes (type 1 and type 2) in children and young people: diagnosis and management

March 31st 2022

NICE guideline [NG18]Published: 01 August 2015 Last updated: 31 March 2022 (NICE)

Categories: Guidance, News, Paediatrics
Tags: NICE, Type 1 Diabetes, Type 2 Diabetes

Categories: Guidance, Paediatrics
Tags: NICE, Type 1 Diabetes, Type 2 Diabetes

Glycemic outcomes of Advanced Hybrid Closed Loop system in children and adolescents with Type 1 Diabetes, previously treated with Multiple Daily Injections (MiniMed 780G system in T1D individuals, previously treated with MDI)

March 30th 2022

Children and adolescents with T1D on MDI therapy who initiated the AHCL system following a 10-days structured protocol achieved the internationally recommended goals of glycemic control with TIR > 70% and a HbA1c of < 7% (BMC Endocrine Disorders)

Categories: News, Paediatrics
Tags: closed-loop, glycaemic control, Type 1 Diabetes

Categories: Paediatrics
Tags: closed-loop, glycaemic control, Type 1 Diabetes

Current Management of Glycemia in Children with Type 1 Diabetes Mellitus

March 24th 2022

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors’ clinical recommendations (NEJM)

Categories: News, Treatment
Tags: Type 1 Diabetes

Categories: Treatment
Tags: Type 1 Diabetes

Mortality trends in type 1 diabetes: a multicountry analysis of six population-based cohorts

March 23rd 2022

This is the first multicountry analysis of six large contemporary population-based studies, and shows that all-cause mortality in people with type 1 diabetes has declined in recent years in most studied populations. However, excess mortality relative to the population without diabetes remains high in people with type 1 diabetes (Diabetologia)

Categories: News, Prevalence
Tags: international, mortality, Type 1 Diabetes

Categories: Prevalence
Tags: international, mortality, Type 1 Diabetes

Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes

March 9th 2022

The current studies provide crucial mechanistic and clinical insight into the beneficial effects of verapamil in T1D (Nature)

Categories: Medication, News
Tags: Type 1 Diabetes, verapamil

Categories: Medication
Tags: Type 1 Diabetes, verapamil

The Gut Microbiome of Adults With Type 1 Diabetes and Its Association With the Host Glycemic Control

March 6th 2022

We identified a distinct gut microbial signature in adults with longstanding T1D and associations between microbial taxa, metabolic pathways, and glycemic control indices (Diabetes Care)

Categories: News, Pathology
Tags: microbiome, Type 1 Diabetes

Categories: Pathology
Tags: microbiome, Type 1 Diabetes

Real-world Evidence of Efficacy and Safety of SGLT2 Inhibitors as Adjunctive Therapy in Adults With Type 1 Diabetes: A European Two-Center Experience

March 6th 2022

Our real-world data on SGLT2i showed promising results in reductions in HbA1c, weight, and insulin requirements in type 1 diabetes. Benefits were more pronounced in individuals with higher baseline HbA1c and BMI. DKA remained a major concern, despite educational measures (Diabetes Care)

Categories: Medication, News
Tags: SGLT2 inhibitors, Type 1 Diabetes

Categories: Medication
Tags: SGLT2 inhibitors, Type 1 Diabetes

Joint 30-year HbA1c and lipid trajectories and mortality in type 1 diabetes

February 18th 2022

These results suggest there is a subgroup with type 1 diabetes who, despite poor glycemic control, has a relatively good prognosis, perhaps related to good Non-HDLc (Diabetes Research and Clinical Practice)

Categories: News, Pathology
Tags: glycaemic control, HbA1c, lipid, Type 1 Diabetes

Categories: Pathology
Tags: glycaemic control, HbA1c, lipid, Type 1 Diabetes

Effectiveness of continuous glucose monitoring in maintaining glycaemic control among people with type 1 diabetes mellitus

February 10th 2022

CGM is superior to SMBG in improving glycaemic control among individuals with type 1 diabetes in the community, especially in those with uncontrolled glycaemia (Diabetologia)

Categories: Management, News, Treatment
Tags: CGM, Type 1 Diabetes

Categories: Management, Treatment
Tags: CGM, Type 1 Diabetes

Intra-lymphatic administration of GAD-alum in type 1 diabetes: long-term follow-up and effect of a late booster dose (the DIAGNODE Extension trial)

January 31st 2022

The effect of intra-lymphatic injections of GAD-alum had decreased after 30 months. Good responders showed a specific immune response. Administration of a fourth booster dose after 31.5 months was safe, and there was no decline in C-peptide observed during the 12-month follow-up (Acta Diabetologica)

Categories: News, Treatment
Tags: GAD-alum, Type 1 Diabetes

Categories: Treatment
Tags: GAD-alum, Type 1 Diabetes
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