Hyperfiltration in Type 1 diabetes is primarily driven by alterations in afferent arteriolar resistance rather than efferent arteriolar resistance. Renal protective therapies should focus on afferent renal arteriolar mechanisms through the use of pharmacological agents that target tubuloglomerular feedback, including sodium-glucose cotransporter 2 inhibitors and incretins (Diabetic Medicine)
Diabetes News
Tag: Type 1 Diabetes
Diabetes reversal via gene transfer: building on successes in animal models
The aim of this review is to evaluate the success of cell and gene therapy to reverse T1D in animal models for future clinical application (Dove Press)
Bariatric surgery and diabetes: Implications of type 1 versus insulin-requiring type 2
Our study suggests that improved glycemic control may not be an expected outcome when considering bariatric surgery in patients with DM1; however, additional investigation is warranted (Obesity)
Effect of Subcutaneous Insulin Detemir on Glucose Flux and Lipolysis during Hyperglycaemia in People with Type 1 Diabetes
The results are also consistent with the hypothesis that detemir has a lesser effect on the periphery, as evidenced by a lesser effect on peripheral glucose uptake at specific glucose concentrations (Diabetes, Obesity and Metabolism)
Insulin secretion in patients with latent autoimmune diabetes (LADA): half way between type 1 and type 2 diabetes: action LADA 9
The present study shows that the magnitude of stimulated insulin secretion in LADA is intermediate between that of type 1 and type 2 diabetes mellitus (BMC Endocrine Disorders)
Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients
Serum DPP4 activity is associated with IR in T1DM patients and it might play an important role in its pathophysiology (Diabetes and Its Complications)
Cardiac Autonomic Dysfunction Is Associated With High-Risk Albumin-to-Creatinine Ratio in Young Adolescents With Type 1 Diabetes in AdDIT (Adolescent Type 1 Diabetes Cardio-Renal Interventional Trial)
Adolescents at potentially higher risk for nephropathy show an adverse cardiac autonomic profile, indicating sympathetic overdrive, compared with the lower-risk group. Longitudinal follow-up of this cohort will further characterize the relationship between autonomic and renal dysfunction and the effect of interventions in this population (Diabetes Care)
Plasma Levels of MASP-1 and MASP-2 are Elevated in Type 1 Diabetes and Correlate with Glycaemic Control
MASP-1 and MASP-2 levels were significantly higher in children and adults with T1DM than in their respective control groups (Clinical and Experimental Immunology)
Corneal Confocal Microscopy Predicts 4-Year Incident Peripheral Neuropathy in Type 1 Diabetes
DPN can be predicted by various demographic, metabolic, and conventional neuropathy measures. The ability of CCM to predict DPN broadens the already impressive diagnostic capabilities of this novel ophthalmic marker (Diabetes Care)
NICE guideline consultations
Glycaemic control of Type 1 diabetes in clinical practice early in the 21st century: an international comparison
These results suggest that there are substantial variations in glycaemic control among people with Type 1 diabetes between the data sources and that there is room for improvement in all populations, especially in young adults (Diabetic Medicine)
Treatment of Recent-Onset Type 1 Diabetic Patients With DiaPep277
Results of a Double-Blind, Placebo-Controlled, Randomized Phase 3 Trial (Diabetes Care)
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