The fall in intrapancreatic triacylglycerol in T2DM, which occurs during weight loss, is associated with the condition itself rather than decreased total body fat (Diabetes Care)
Diabetes News
Tag: Type 2 Diabetes
Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia
Individuals with type 2 diabetes are at ∼60% greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women (Diabetes Care)
The Effect of Exercise with or Without Metformin on Glucose Profiles in Type 2 Diabetes: A Pilot Study
The addition of a bout of exercise to metformin led to an increase in postprandial glucose levels without affecting mean glucose concentrations. Removing a metformin dose before or after exercise did not attenuate this negative effect (Canadian Journal of Diabetes)
Osteopontin and osteoprotegerin levels in type 2 diabetes and their association with cardiovascular autonomic function
Our results suggest that OPN is associated with reduced parasympathetic function, particularly in younger individuals with T2DM. Further studies are needed to determine if OPN is neuroprotective, involved in the pathogenesis of autonomic dysfunction, or a bystander (Diabetes and Its Complications)
Novo Nordisk successfully completes fourth phase 3a trial with semaglutide in people with type 2 diabetes
The trial successfully achieved its objective by demonstrating that from a mean baseline HbA1c of 8.1%, people treated with 0.5 mg or 1.0 mg semaglutide achieved a statistically significant and superior improvement in HbA1c of 1.3% and 1.6% respectively, compared to an improvement in HbA1c of 0.5% with 100 mg sitagliptin (Novo Nordisk)
Effects of sitagliptin on circulating zinc-α2-glycoprotein levels in newly diagnosed type 2 diabetes patients: a randomized trial
A low level of circulating ZAG is associated with insulin resistance and sitagliptin treatment significantly increases circulating ZAG levels. These observations have implications in relation to the mode of action of the DPP-IV inhibitor as an insulin sensitizing agent (European Journal of Endocrinology)
Increased circulating osteopontin levels in adult patients with type 1 diabetes mellitus and association with dysmetabolic profile
This study demonstrates for the first time in a case–control study that adults with T1DM have increased serum OPN levels, and that higher OPN concentrations are associated with an unfavorable metabolic profile in these patients (European Journal of Endocrinology)
Mean HbA1c and mortality in diabetic individuals with heart failure: a population cohort study
In patients with T2DM and CHF, our study shows a U-shaped relationship between HbA1c and mortality, with the lowest risk in patients with modest glycaemic control (HbA1c 7.1–8.0%) and those treated with insulin sensitizers (European Journal of Heart Failure)
Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research)
IR existed in the hyperinsulinemia with NGT , impaired glucose tolerance, and T2DM groups, and IR levels were consistent in the three groups. The independent factors influencing IR were waistline andfasting insulin level (Journal of Diabetes Research)
GLP-1 receptor agonist exenatide has no acute effect on MRI-measured exocrine pancreatic function in type 2 diabetes patients: a randomised trial
These findings suggest that potential adverse pancreatic effects of GLP-1 receptor agonists are not mediated by changes in exocrine pancreatic secretion (Diabetes, Obesity and Metabolism)
Pregnancy Outcomes in Youth With Type 2 Diabetes: The TODAY Study Experience
Despite diabetes-specific information recommending birth control and the avoidance of pregnancy, 10% of the study participants became pregnant. Pregnancies in youth with type 2 diabetes may be especially prone to result in congenital anomalies. Reasons for the high rate of congenital anomalies are uncertain, but may include poor metabolic control and extreme obesity (Diabetes Care)
Diabetes mellitus type 1 and type 2: insulin glargine biosimilar (Abasaglar)
In 2 randomised controlled trials (RCTs) insulin glargine biosimilar (Abasaglar) was as effective as insulin glargine (Lantus) at reducing HbA1c levels in people with type 1 and type 2 diabetes. The safety profile of Abasaglar is comparable to that of Lantus (NICE)
Type 2 diabetes in adults: management
This guideline covers the care and management of type 2 diabetes in adults (aged 18 and over). It focuses on patient education, dietary advice, managing cardiovascular risk, managing blood glucose levels, and identifying and managing long-term complications (NICE)
Screening for Abnormal Blood Glucose and Type 2 Diabetes Mellitus: U.S. Preventive Services Task Force Recommendation Statement
The USPSTF recommends screening for abnormal blood glucose as part of cardiovascular risk assessment in adults aged 40 to 70 years who are overweight or obese (Annals of Internal Medicine)
Use of cardiovascular medicines in newly treated type 2 diabetes patients: A retrospective cohort study in general practice
Substantial CVD agent utilisation was noted 1 year after antidiabetic agent initiation. Being aged younger than 60–69 years was associated with decreased utilisation of CVD agents (Primary Care Diabetes)
Insulin Resistance and Inflammation in Hypogonadotropic Hypogonadism and Their Reduction After Testosterone Replacement in Men With Type 2 Diabetes
Testosterone treatment in men with type 2 diabetes and HH increases insulin sensitivity, increases lean mass, and decreases subcutaneous fat (Diabetes Care)
Blood pressure and glycaemic effects of dapagliflozin versus placebo in patients with type 2 diabetes on combination antihypertensive therapy
Dapagliflozin 10 mg significantly improved blood pressure and HbA1C. Its blood pressure-lowering properties were particularly favourable in patients already receiving a β blocker or calcium-channel blocker. Dapagliflozin could benefit patients with type 2 diabetes who need a diuretic-like effect to optimise control of blood pressure (The Lancet Diabetes & Endocrinology)
Clinical coaching in primary care: Capable of improving control in patients with type 2 diabetes mellitus?
A correctible and even preventable contributing component in diabetes care corresponds to physicians’ performance. After 3 years of implementation, coaching was found to be worth the effort to improve type 2 diabetes control in primary care (Primary Care Diabetes)
Lactation and Progression to Type 2 Diabetes Mellitus After Gestational Diabetes Mellitus: A Prospective Cohort
Higher lactation intensity and longer duration were independently associated with lower 2-year incidences of DM after GDM pregnancy (Annals of Internal Medicine)
Implementing An Optimized Glucose-Lowering Strategy with a Novel Once Daily Modified Release Gliclazide Formulation
In this large, real world study, progressive uptitration with gliclazide MR 60 mg once daily appears to be efficacious and safe in individuals with suboptimal glycemic control at various stages of the diabetes continuum (Diabetes Research and Clinical Practice)
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