Among overweight and obese participants with type 2 diabetes, use of subcutaneous liraglutide (3.0 mg) daily, compared with placebo, resulted in weight loss over 56 weeks. Further studies are needed to evaluate longer-term efficacy and safety (JAMA)
Diabetes News
Tag: Type 2 Diabetes
Comparison of basal insulin therapies regarding the risk of acute myocardial infarction in type 2 diabetic patients
In contrast to a former database study, no difference was observed for the risk of AMI between long-acting analog and NPH insulin in this study. Neither long-acting analog insulin nor premix insulin appears to be associated with AMI in patients with type 2 diabetes (Diabetes, Obesity and Metabolism)
A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses
The Mediterranean diet was associated with better glycaemic control and cardiovascular risk factors than control diets, including a lower fat diet, suggesting that it is suitable for the overall management of type 2 diabetes (BMJ Open)
Delay in treatment intensification increases the risks of cardiovascular events in patients with type 2 diabetes
Among patients with newly diagnosed T2DM, 22% remained under poor glycaemic control over 2 years, and 26% never received IT. Delay in IT by 1 year in conjunction with poor glycaemic control significantly increased the risk of MI, HF, stroke and composite CVE (Cardiovascular Diabetology)
Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes
Our results indicate that metformin intake activates AMPK and consequently suppresses FADS, which leads to reduced levels of the three acyl-alkyl PCs and LDL-C. Our findings suggest potential beneficial effects of metformin in the prevention of cardiovascular disease (Diabetes Care)
The revised NICE draft guideline for type 2 diabetes: still a long way to go
Some positive changes have been made since the first draft was published in January, 2015, especially with respect to patient preferences. However, we believe that the revised guideline remains unfit for purpose and is a missed opportunity to improve the lives of patients with type 2 diabetes (Lancet)
Coronary microvascular function is independently associated with left ventricular filling pressure in patients with type 2 diabetes mellitus
CFR was associated with LV filling pressure in patients with type 2 diabetes. This result suggests a possible link between coronary microvascular disease and LV diastolic function in these subjects (Cardiovascular Diabetology)
Fasting Until Noon Triggers Increased Postprandial Hyperglycemia and Impaired Insulin Response After Lunch and Dinner in Individuals With Type 2 Diabetes
Skipping breakfast increases PPHG after lunch and dinner in association with lower iGLP-1 and impaired insulin response (Diabetes Care)
Type 1 Diabetes Is Associated With an Increased Risk of Fracture Across the Life Span
Type 1 diabetes was associated with increased risk of incident fracture that began in childhood and extended across the life span (Diabetes Care)
Diabetic Ketoacidosis and Related Events in the Canagliflozin Type 2 Diabetes Clinical Program
DKA and related events occurred at a low frequency in the canagliflozin type 2 diabetes program, with an incidence consistent with limited existing observational data in the general population with type 2 diabetes (Diabetes Care)
Glycemic and Cholesterol Control Versus Single-Goal Control in US Veterans with Newly Diagnosed Type 2 Diabetes
Dual-goal achievement in newly diagnosed type 2 diabetes is associated with a lower risk of microvascular complications versus only LDL-C goal achievement. Although dual-goal achievement rates are suboptimal, early and regular intervention will increase its likelihood (Diabetes Therapy)
The impact of nonalcoholic fatty liver disease on incident type 2 diabetes mellitus in non-overweight individuals
Non-overweight individuals with NAFLD had a high risk of incident T2DM. Diagnosis of NAFLD is important in non-overweight individuals, and therefore it might be necessary to follow their health conditions on a long-term basis after detection of NAFLD (Liver International)
Efficacy and safety of once weekly glucagon-like peptide 1 receptor agonists for management of type 2 diabetes
Given their dosing scheme and overall efficacy and safety profile once weekly GLP-1 RAs are a convenient therapeutic option as add-on to metformin (Diabetes, Obesity and Metabolism)
Admission blood glucose predicts mortality and length of stay in patients admitted through the emergency department
Admission BGL was independently associated with increased mortality in patients with no diagnosis of diabetes. Glycaemic variability was associated with increased length of hospital stay in patients with type-2 diabetes (Internal Medicine Journal)
Vitamin D status is associated with skin autofluorescence in patients with type 2 diabetes mellitus: a preliminary report
Vitamin D status is independently associated with skin auto fluorescence in patients with well-controlled T2DM. No effect was seen on the amount of skin AGEs after a short period of 6 months vitamin D supplementation. Further research with longer follow-up and measurement of circulating advanced glycation end products is needed to elucidate the causality of the association (Cardiovascular Diabetology)
Elevated glycated albumin and reduced endogenous secretory receptor for advanced glycation endproducts levels in serum predict major adverse cardio-cerebral events in patients with type 2 diabetes and stable coronary artery disease
Serum GA and esRAGE are novel predictors of long-term clinical outcomes in patients with type 2 diabetes and stable CAD. Increased serum GA and decreased esRAGE are associated with a poor prognosis in such patients (International Journal of Cardiology)
Potential glycemic overtreatment in patients ≥75 years with type 2 diabetes mellitus and renal disease
In clinical practice, a substantial proportion of elderly patients may be overtreated. RI is insufficiently taken into account when prescribing OAD (Diabetes, Metabolic Syndrome and Obesity)
Use of a basal-plus insulin regimen in persons with type 2 diabetes stratified by age and body mass index: A pooled analysis of four clinical trials
These results suggest that the use of ‘basal-plus’ can achieve a good therapeutic response with a low risk of hypoglycemia and weight gain, regardless of a patient’s age or BMI (Primary Care Diabetes)
Contemporary Risk Estimates of Three HbA1c Variables for Myocardial Infarction in 101,799 Patients Following Diagnosis of Type 2 Diabetes
The two time-updated HbA1c variables show a stronger relation with MI than baseline HbA1c. The risk association between HbA1c and MI has decreased over time. In recently diagnosed patients with type 2 diabetes, an increased risk of MI exists at a current HbA1c of <6.0% (42 mmol/mol) (Diabetes Care)
Predictors of all-cause and cardiovascular disease mortality in type 2 diabetes: Diabetes Heart Study
This analysis highlights important demographic and clinical factors, notably CAC and albuminuria, which predict mortality in the general population of patients with T2D (Diabetology & Metabolic Syndrome)
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