The Effect of Type 2 Diabetes Risk Loci on Insulin Requirements in Type 1 Diabetes

We identified two T2D susceptibility loci that modulate insulin requirements in T1D patients. Our results are consistent with the association of lower insulin secretion with higher insulin sensitivity. To explain the continuation of this correlation after ß-cell destruction, we hypothesize an epigenetic mechanism that alters insulin responsiveness in T1D patients based on ß-cell function in early life (Hormone Research in Paediatrics)