Creatinine-based eGFR and albuminuria should be taken into account for cardiovascular prediction, especially when these measures are already assessed for clinical purpose or if cardiovascular mortality and heart failure are outcomes of interest (The Lancet Diabetes & Endocrinology)
Archives for June 2015
An antenatal HE intervention is associated with less GWG and lower fasting glucose compared with PA alone. These findings require a larger trial for confirmation but support the use of early HE interventions in obese pregnant women (Diabetes Care)
The findings of no significant difference regarding amputation and healing between telemedical and standard outpatient monitoring seem promising; however, for telemedical monitoring, a higher mortality throws into question the role of telemedicine in monitoring diabetic foot ulcers (Diabetes Care)
As the two different types of data represent independent and complementary information on the outcome, the combined model resulted in a reliable screening method that is comparable to the requirements of DR screening programs applied in clinical routine (Journal of Diabetes Research)
Published by Elsevier
For some healthcare professionals who are not ophthalmologists, diseases of the eyes can be a difficult to understand topic. Like any topic, once you master it then all of a sudden it seems a lot easier and makes much more sense. Certainly one way to master ophthalmology and get a better comprehension of the subject is to have access to this outstanding and excellent textbook. It is primarily aimed at specialist ophthalmologists both established and those in the training grades. However GPs with a special interest in ophthalmology or GPs who want an all-encompassing ophthalmology textbook may find that this fits the bill. Though for the latter group it may be a bit excessive for their needs.
The reported results underline the role of Mediterranean diet as a promising dietary tool for the primary prevention of diabetes, by attenuating inflammation and fostering TAC; thus, this dietary pattern may have a therapeutic potential for a plethora of cardio-metabolic disorders, resulting from inflammation and/or oxidative stress (Diabetes/Metabolism Research and Reviews)
Insulin therapy in elderly people with type 2 diabetes can lead to an improvement of depressive symptoms and does not seem to affect negatively HRQoL of the participants (Diabetology & Metabolic Syndrome)
In a large cohort with a 5-year follow-up and in a multicenter network setting, islet transplantation was safe and efficient in restoring good and lasting glycemic control, and to prevent severe hypoglycemia in patients with type 1 diabetes (Diabetes Care)
Treatment is not recommended outside pregnancy because glucose-lowering therapy is ineffective in people with GCK-MODY and there is a lack of long-term complications (Diabetes Care)
This guidance is intended to help both general and specialist practitioners make informed choices and provide optimal care for patients with T2D (Diabetes Therapy)
The results show that in a patient population with sub-optimal glycemic control at baseline, and a low target achievement rate together with a low rate of hypoglycemia, differences in the patient reported outcomes evaluated in this study were negligible between insulin glargine and NPH insulin (Health and Quality of Life Outcomes)
This “smart insulin patch” with a new enzyme-based glucose-responsive mechanism can regulate the blood glucose of type 1 diabetic mice to achieve normal levels, with faster responsiveness compared with the commonly used pH-sensitive formulations, and can avoid the risk of hypoglycemia (PNAS)
A summary of a report from the Joint British Diabetes Societies for Inpatient Care (BJDVD)
Treatment with a long-acting GLP-1 RA increased bone formation by 16% and prevented
bone loss after weight loss obtained through a low calorie-diet, supporting its role as a safe
weight-lowering agent (JCEM)
Enrichment of gut microbiota with L. reuteri increases insulin secretion, possibly due to augmented incretin release, but does not directly affect insulin sensitivity or body fat distribution. This suggests that oral ingestion of one specific strain may serve as a novel therapeutic approach to improve glucose-dependent insulin release (Diabetes Care)
Sclerostin levels are increased in individuals with prediabetes and correlated with insulin resistance in skeletal muscle, liver, and adipose tissue. The correlation between sclerostin and insulin clearance at fasting state and during OGTT is novel; thus, studies are needed to explore the potential causal relationship (Diabetes Care)
Author: Judith Jones-Ambrosini
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Use of metformin in people with type 2 diabetes and a serum creatinine concentration greater than 530 μmol/L is associated with a significantly increased risk of all-cause mortality compared with non-users. Metformin use should not be encouraged in this patient group (The Lancet Diabetes & Endocrinology)
These observations suggest that altered intestinal microbiota may be associated with disease susceptibility (Diabetes)
A Systematic Review and Meta-Analysis of Population Based Studies (PLOS ONE)