The absolute global economic burden will increase from U.S. $1.3 trillion in 2015 to $2.2 trillion in the baseline, $2.5 trillion in the past trends, and $2.1 trillion in the target scenarios by 2030 (Diabetes Care)
Diabetes News
Glycosmedia is dedicated to bringing free, non-promotional, editorially independent news to a global audience about developments in diabetes, and is primarily aimed at health professionals.
Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis
Artificial pancreas systems are an efficacious and safe approach for treating outpatients with type 1 diabetes. The main limitations of current research evidence on artificial pancreas systems are related to inconsistency in outcome reporting, small sample size, and short follow-up duration of individual trials (BMJ)
Association Between Use of Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-like Peptide 1 Agonists, and Dipeptidyl Peptidase 4 Inhibitors With All-Cause Mortality in Patients With Type 2 Diabetes
In patients with type 2 diabetes, the use of SGLT-2 inhibitors or GLP-1 agonists was associated with better mortality outcomes than DPP-4 inhibitors (JAMA)
Sodium‐glucose co‐transporter‐2 inhibitors, the latest residents on the block: Impact on glycaemic control at a general practice level in England
We found that SGLT inhibitors may be superior to other oral agents in relation to HbA1c outcome. Serious consideration should be given to their use(Diabetes, Obesity and Metabolism)
Effects of metformin, rosiglitazone and insulin on bone metabolism in patients with type 2 diabetes
The choice of insulin treatment is not influencing BTMs, metformin treatment may decrease BTMs, and improvement of glycaemic control may influence bone resorption activity (Bone)
Mean HbA1c, HbA1c variability, and mortality in people with diabetes aged 70 years and older: a retrospective cohort study
Both low and high levels of glycaemic control were associated with an increased mortality risk, and the level of variability also seems to be an important factor, suggesting that a stable glycaemic level in the middle range is associated with lower risk (The Lancet Diabetes & Endocrinology)
State of Diabetes Self-Management Education in the European Union Member States and Non-EU Countries: The Diabetes Literacy Project
Variation in availability and organization of DSME in the EU MS presents a clear rationale for developing an EU-wide diabetes strategy to improve treatment and care for people with diabetes (Journal of Diabetes Research)
Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus
A Guidance Statement Update From the American College of Physicians
Evidence-based nutrition guidelines for the prevention and management of diabetes
Our set of nutrition recommendations for adults with diabetes and those at risk of Type 2 diabetes have been written for healthcare professionals who are supporting them (Diabetes UK)
Insulin/Glucagon-Like Peptide-1 Receptor Agonist Combination Therapy for the Treatment of Type 2 Diabetes: Are Two Agents Better Than One?
We consider the benefits and limitations of these medications based on data from randomized clinical trials and discuss how they may address barriers to treatment intensification (Clinical Diabetes)
How Does Diabetes Affect Daily Life? A Beyond-A1C Perspective on Unmet Needs
Patients across cultures and countries report negative experiences from diabetes, not only with regard to glycemia, but also regarding physical, emotional, social, and financial health metrics. Diabetes is a 24/7 unwanted job with no vacations, breaks, or set-it-and-forget-it phone apps (Clinical Diabetes)
Gender differences in the evaluation of care for patients with type 2 diabetes: a cross-sectional study (ZODIAC-52)
Only a few factors were found to be associated with patients’ evaluation of care for men and women with T2D. Taken together, these factors explained only a small part of the variance of the EUROPEP scores. This explained variance was largely attributable to the location where the questionnaire was completed (BMC Health Services Research)
HbA1c variability and diabetic peripheral neuropathy in type 2 diabetic patients
Increased HbA1c variability is closely associated with DPN in type 2 diabetic patients and could be considered as a potent indicator for DPN in these patients (BMC Health Services Research)
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Glucose alert system improves health professional responses to adverse glycaemia and reduces the number of hyperglycaemic episodes in non‐critical care inpatients
Use of a novel glucose alert system improved health professional responses to adverse glycaemia and decreased hyperglycaemia in the hospital setting (Diabetic Medicine)
Cost-effectiveness of insulin pumps compared with multiple daily injections both provided with structured education for adults with type 1 diabetes
A health economic analysis of the Relative Effectiveness of Pumps over Structured Education (REPOSE) randomised controlled trial. Our analysis of the REPOSE data suggests that routine use of pumps in adults without an immediate clinical need for a pump, as identified by National Institute for Health and Care Excellence, would not be cost-effective (BMJ Open)
Long-term outcomes associated with triple-goal achievement in patients with type 2 diabetes mellitus
Achievement of triple-goal was associated with better health outcomes among veterans with T2DM compared to those that did not, while LDL-C has more weight of influence. Multi-faceted treatment strategies targeting hypertension, hyperglycemia and hyperlipidemia may improve health outcome in veterans with T2DM (Diabetes Research and Clinical Practice)
GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes
The results identify GABA as a potent regulator of both Th1- and Th2-type cytokine secretion from human PBMCs and CD4+ T cells where GABA generally decreases the secretion (EBioMedicine)
Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
The findings reveal unique GABAA receptors signaling in human islets β cells that is GABA concentration-dependent, differentially regulated by drugs, modulates insulin secretion and is altered in T2D (EBioMedicine)
Optimal cutoff values of fasting plasma glucose (FPG) variability for detecting retinopathy and the threshold of FPG levels for predicting the risk of retinopathy in type 2 diabetes
Our study provides new cutoff values for FPG variability. Cutoff values of FPG and HbA1c were slightly higher than recommended targets of the current guideline. The threshold of FPG levels (6.9 mmol/L) is proposed to predict retinopathy incidence during the subsequent 25 years (Diabetes Research and Clinical Practice)
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