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Diabetes News
Glycosmedia is dedicated to bringing free, non-promotional, editorially independent news to a global audience about developments in diabetes, and is primarily aimed at health professionals.
Insulin resistance correlates with maculopathy and severity of retinopathy in young adults with Type 1 Diabetes Mellitus
IR correlates with more severe retinopathy in young adults with Type 1 DM. This is the first description of a correlation between IR and maculopathy in Type 1 DM, warranting further evaluation. Prospective studies examining whether reducing IR can improve microvascular complications are required (Diabetes Research and Clinical Practice)
Obese, overweight with risk factors: liraglutide (Saxenda)
This evidence summary discusses 4 randomised controlled trials (RCTs) in adults who were obese or overweight (BMI 27 kg/m2 or above) with a variety of weight-related comorbidities including dyslipidaemia, hypertension, type 2 diabetes and obstructive sleep apnoea (NICE)
Lipoprotein Insulin Resistance Score and Risk of Incident Diabetes During Extended Follow-Up of 20 Years: The Women’s Health Study
In middle aged or older healthy women followed prospectively over 20 years, LPIR was robustly associated with incident T2D, including among those with an optimal clinical metabolic profile. LPIR improved T2D risk classification and may guide early and targeted prevention strategies (Journal of Clinical Lipidology)
National Diabetes Transition Audit Report
This is the first published report for the NDTA and contains linked data from the NPDA and NDA for the audit period 2003-04 to 2013-14. The report covers young people with Type 1 diabetes (HQIP)
Surgical and Advanced Medical Therapy for the Treatment of Type 2 Diabetes in Class I Obese Patients: a Short-Term Outcome
Bariatric surgery is a safe and effective procedure to treat T2DM in class I obese patients. It is also superior to advance medical treatment modalities such as GLP-1 analogues and SGLT2 inhibitors (Obesity Surgery)
Biliopancreatic Diversion with Duodenal Switch Leads to Better Postprandial Glucose Level and Beta Cell Function than Sleeve Gastrectomy in Individuals with Type 2 Diabetes Very Early After Surgery
Our findings support the notion that caloric restriction represents an important mechanism to explain the very early anti-diabetic effects observed after bariatric surgery. However, exclusion of the upper gastrointestinal tract also provides further metabolic improvements, possibly mediated by gastrointestinal hormonal responses and altered postprandial glucose absorption (Metabolism – Clinical and Experimental)
European diabetes research and its funding, 2002–2013
The European diabetes burden in disability-adjusted life years increased by one third between 2002 and 2012, but its output of research papers has decreased from 44% to 36% of the world total. This decrease needs to be reviewed in the context of European non-communicable disease research policy (Diabetic Medicine)
Three-year efficacy and safety of exenatide once weekly: A pooled analysis of three trials
Exenatide QW improved glycemic outcomes and was well tolerated in patients with T2D for up to 156 weeks (Diabetes and Its Complications)
Relationship Between Duration of Type 2 Diabetes and Effectiveness of DPP-4 Inhibitor Versus Sulfonylurea as Add-on Therapy: A Post Hoc Analysis
Vildagliptin demonstrated less dependency on the duration of type 2 diabetes, whereas the effectiveness of SUs diminished faster with increasing duration of the disease in a real-life setting (Diabetes Therapy)
Facing the tidal wave De-risking pharma and creating value for patients
This paper examines some of the underlying drivers of the ‘tidal wave’ of diseases, illustrates an alternative way of thinking about the demand challenges and suggest some emerging ways in which industry and the healthcare system can address them (Deloitte)
Health Effects of Overweight and Obesity in 195 Countries over 25 Years
The rapid increase in the prevalence and disease burden of elevated BMI highlights the need for continued focus on surveillance of BMI and identification, implementation, and evaluation of evidence-based interventions to address this problem (NEJM)
Safety and Tolerability of Empagliflozin in Patients with Type 2 Diabetes: Pooled Analysis of Phase I–III Clinical Trials
This analysis of pooled safety data based on >15,000 patient-years’ exposure support a favorable benefit-risk profile of empagliflozin in patients with T2DM
Sleep and glycemic control in adolescents with type 1 diabetes
Our study suggests that poor sleep quality is associated with increased HbA1c in adolescents with type 1 diabetes and that higher levels of circadian misalignment are associated with increased insulin requirements. If replicated, our results indicate a clinical relevance of sleep habits in adolescents with type 1 diabetes (Pediatric Diabetes)
Use of SGLT2 inhibitors for diabetes and risk of infection: Analysis using general practice records from the NPS MedicineWise MedicineInsight program
Similar to existing evidence, we found a higher risk of genital infection associated with SGLT2 inhibitors (primarily dapagliflozin) but no increased risk of UTIs compared to DPP-4 use (Diabetes Research and Clinical Practice)
Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight
This data is the first to show that glyburide increases GLUT 1 expression in syncytiotrophoblast MVM and BM in GDM pregnancies, and may promote transplacental glucose delivery contributing to fetal overgrowt (Placenta)
Early short-term intensive multidisciplinary diabetes care: A ten-year follow-up of outcomes
Initiation of earlier intensive short-term multidisciplinary interventions in patients with newly diagnosed DM may decrease coronary heart disease and nephropathy. These better outcomes may be related to less fluctuation in blood glucose levels (Diabetes Research and Clinical Practice)
Hypoglycemic Event Frequency and the Effect of Continuous Glucose Monitoring in Adults with Type 1 Diabetes Using Multiple Daily Insulin Injections
In the DIAMOND randomized controlled trial, participants in the CGM group experienced a greater reduction in hypoglycemic event rate than participants receiving usual care in the control group (Diabetes Therapy)
Effectiveness and feasibility of nailfold microcirculation test to screen for diabetic peripheral neuropathy
The nailfold MI is a feasible method for clinical early diagnostic screening of DPN in diabetic patients, and is more objective and reliable than VPT (Diabetes Research and Clinical Practice)
Racial Differences in the Relationship of Glucose Concentrations and Hemoglobin A1c Levels
On average, HbA1c levels overestimate the mean glucose concentration in black persons compared with white persons, possibly owing to racial differences in the glycation of hemoglobin. However, because race only partially explains the observed HbA1c differences between black persons and white persons, future research should focus on identifying and modifying barriers impeding improved glycemic control in black persons with diabetes (Annals of Internal Medicine)
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