Closed loop insulin delivery devices are promising treatment strategies and are likely to be used in clinical practice in the short term. But this approach will always suffer from delays in glucose measurement and insulin action preventing it from normalizing glycemic control. In the long term, stem cell-derived beta cell transplantation may be able to achieve this, but wide implementation in clinical practice is still far away (Current Diabetes Reports)
Diabetes News
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Recent Advances in the Development of Vaccines for Diabetes, Hypertension, and Atherosclerosis
Metabolic diseases are becoming the first noticeable disorder which threatens the health and longevity of human. Vaccines are powerful tools in this battle if used properly (Journal of Diabetes Research)
Time to Treatment Intensification After Monotherapy Failure and Its Association With Subsequent Glycemic Control Among 93,515 Patients With Type 2 Diabetes
Earlier treatment intensification is associated with shorter time to subsequent glycemic control, independent of whether patients initiate first-line treatment with metformin or a sulfonylurea (Diabetes Care)
Association between maternal gluten intake and type 1 diabetes in offspring: national prospective cohort study in Denmark
High gluten intake by mothers during pregnancy could increase the risk of their children developing type 1 diabetes. However, confirmation of these findings are warranted, preferably in an intervention setting (BMJ)
Early vascular parameters in the micro- and macrocirculation in type 2 diabetes
These data suggest that at similar blood pressure capillary rarefaction in the retinal circulation (ICD), decreased eGFR in the renal circulation and increased central pulse pressure (cPP) of large arteries are earlier detectable than other vascular remodeling parameters of the micro- (WLR, RCF, UACR) and macrocirculation (cSBP) in patients with T2DM (Cardiovascular Diabetology)
Increased Residual Cardiovascular Risk in Patients with Diabetes and High vs. Normal Triglycerides Despite Statin‐Controlled LDL Cholesterol
Despite statin‐controlled LDL‐C levels, CV events were greater among patients with diabetes and high TG levels. Because we controlled for cardiometabolic risk factors, it is likely that the difference in TG levels contributed to the excess risk observed in patients with high TGs (Diabetes, Obesity and Metabolism)
Cognitive functioning and structural brain abnormalities in people with Type 2 diabetes mellitus
In people with long‐standing, less strictly controlled Type 2 diabetes, white matter hyperintensities volumes were associated with decreased processing speed. This suggests that cerebral small vessel disease is an underlying disease mechanism of cognitive dysfunction in these individuals (Diabetic Medicine)
Enteroviral Infections as a Trigger for Type 1 Diabetes
New evidence at the protein, RNA, and host immune response level suggests a role for EV infections in the development of autoimmunity. In the upcoming years, new technologies, collaborative efforts, and therapeutic interventions are likely to find a definitive answer for their role in disease pathogenesis (Current Diabetes Reports)
Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions
In conclusion, even if patients with T2DM are characterized by different rates of disease progression and the clinical presentation of the disease could lead to insulin treatment initiation per se, the analysis of the collected data allows us to partly respond to typical patient’s question “will I need insulin?,” which originated in this paper (Journal of Diabetes Research)
A Prospective Cohort Study on the Management of Young Patients with Newly Diagnosed Type 2 Diabetes Using Mobile Medical Applications
A mobile medical app is helpful to young patients with newly diagnosed T2DM for monitoring their blood glucose level and improving their blood glucose control to meet the standard (Diabetes Therapy)
Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment
Taken together, increased recognition of diabetic enteropathy may allow earlier diagnosis and intervention. This gives rise to hope for the recognition of diabetic enteropathy at an earlier time and specific diagnoses in the future. Finally, more targeted nonpharmacological and pharmacological treatments and interventions can be individually tailored based on pathophysiological findings, in order to improve patient outcomes (Journal of Diabetes Research)
Diabetes and Diet: A Patient and Dietitian’s Perspective
This article has been co-authored by a patient with type 2 diabetes and a specialist dietitian. Here they discuss the patient’s experience and difficulties with controlling weight and strategies that can help a patient in this situation (Diabetes Therapy)
Improved Postprandial Glucose with Inhaled Technosphere Insulin Compared with Insulin Aspart in Patients with Type 1 Diabetes on Multiple Daily Injections: The STAT Study
We conclude that using TI appropriately at mealtimes with supplemental dosing improves prandial glucose (TIR and 1–4 h) control without any increase in time in hypoglycemia or weight gain in patients with T1DM on MDI (Diabetes Technology and Therapeutics)
Neuropad for detecting preclinical diabetic peripheral neuropathy
The case for adopting Neuropad to detect preclinical diabetic peripheral neuropathy is not supported by the evidence (NICE)
Metabolic Control in Type 1 Diabetes: Is Adjunctive Therapy the Way Forward?
Restricting therapy for T1DM to insulin replacement is perhaps an over-simplistic approach, and we focus in this work on reviewing the role of adjuvant therapy in this population (Diabetes Therapy)
Midlife development of type 2 diabetes and hypertension in women by history of hypertensive disorders of pregnancy
Women with history of HDP are not only at higher risk of cardiometabolic disease during their reproductive years, but HDP is also associated with midlife T2D development above and beyond established risk factors (Cardiovascular Diabetology)
Positive 15-month results with Diamyd® in Type 1 diabetes
When all patients have been followed for 15 months in the diabetes trial DIAGNODE-1, where the diabetes vaccine Diamyd® is given directly into the lymph node, a clearly positive and clinically relevant effect is seen in improving the clinical course and maintaining the endogenous insulin production in newly diagnosed type 1 diabetes (Diamyd Medical)
Risk of type 2 diabetes and cardiovascular disease in an incident cohort of people with psoriatic arthritis: a population-based cohort study
The development of T2D in an incident population of PsA is significantly higher than in psoriasis alone or in a general population, whereas the increased risk of cardiovascular disease in PsA and psoriasis is similar (Rheumatology)
Longitudinal relationship between retinal diabetic neurodegeneration and progression of diabetic retinopathy in patients with type 2 diabetes
Progressive loss of mGCIPL is an independent risk factor for progression in early-stage DR. Further assessment of autonomic and peripheral nerve functions can increase sensitivity in predicting aggravation of DR in patients with T2DM (American Journal of Ophthalmology)
Combination Therapy with GLP-1 Receptor Agonists and SGLT-2 Inhibitors in Older Patients with Type 2 Diabetes: a Real-World Evidence Study
This study’s findings provide evidence of clinically-meaningful reductions in HbA1c, body weight, and SBP in older T2D patients on combined regimens. The dropout and hypoglycemia rate were minimal and treatment was tolerated well (Canadian Journal of Diabetes)
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