The last 5 years have seen a huge increase in the number of new anti-diabetes agents reaching the market, from new insulins to novel injectable and oral agents However, given changes to drug regulation following the Rosiglitazone debacle and the current financial climate, there are signs that the conveyor belt of agents is either slowing or coming to a halt. The two latest ‘blockbusters’, Novos new insulin Degludec (Tresiba) and Astra Zeneca’s SGLT2 inhibitor Dapaglafozin (Forxiga) have had major issues achieving either approval or formulary status.

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