Aging is associated with increased HbA1c levels, independently of glucose levels and insulin resistance, and also with decreased diagnostic specificity

In two large datasets, using different methods to measure HbA1c, the association of age with higher HbA1c levels: was consistent and similar; was both statistically and clinically significant; was unexplained by features of aging; and reduced diagnostic specificity. Age should be taken into consideration when using HbA1c for the diagnosis and management of diabetes and prediabetes (Diabetic Medicine)