Concanavalin A-based glucose-responsive nanogels

Glucose-responsive polymer nanogels that can undergo a reversible and rapid volume phase transition in response to the fluctuation in blood glucose concentration have the potential to regulate delivery of insulin mimicking pancreas activity. We report here such a glucose-responsive polymer nanogel, which is made of Concanavalin A (ConA) interpenetrated in a chemically-crosslinked network of poly(N-isopropylacrylamide) (poly(NIPAM)) (Polymer Chemistry)