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Diabetes News April 20th 2012

April 20th 2012

Impact of Statins on the Coagulation Status of Type 2 Diabetes Patients Evaluated by a Novel Thrombin-Generation Assay
The use of a standardized, easy-to-run, and commercially available APC-dependent thrombin-generation assay detected the presence of a procoagulant status in a large series of patients with long-standing T2D and demonstrated a significant impact of statins in the coagulation status of patients with T2D (Cardiovascular Drugs and Therapy)

Thrombin generation in type 2 diabetes with albuminuria and macrovascular disease
Our results support the hypothesis that TG may be involved in the pathogenesis of MVD in diabetic nephropathy as for the first time, we could show that patients with T2DM in different stages of diabetic nephropathy had disturbances in thrombin generation (European Journal of Clinical Investigation)

Effects of a combination of oral anti-diabetes drugs with basal insulin therapy on ß-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes
In newly diagnosed type 2 diabetes, therapy with oral drugs+insulin has had favourable outcomes on recovery and maintenance of ß-cell function and protracted glycaemic remission compared with treatment with oral drugs alone (Diabetes/Metabolism Research and Reviews)

Management of hyperglycaemia in type 2 diabetes
A patient-centered approach. Position statement of the American Diabetes Association and the European Association for the Study of Diabetes (Diabetologia)

Association between tamoxifen treatment and diabetes
Current tamoxifen therapy is associated with an increased incidence of diabetes in older breast cancer survivors. These findings suggest that tamoxifen treatment may exacerbate an underlying risk of diabetes in susceptible women (Cancer)

Sensorineural hearing loss is a common finding in early onset type 2 diabetes
Patients with early onset T2DM and poor glycemic control have an increased prevalence of subclinical hearing loss and impaired auditory brainstem responses. Hearing impairment may be an under-recognized complication of diabetes (Endocrine Practice)

Protein tyrosine phosphatase 1B inhibitors: A molecular level legitimate approach for the management of diabetes mellitus
The drug discovery research in PTP 1B is a challenging area to work with and many pharmaceutical organizations and academic research laboratories are focusing their research toward the development of potential PTP 1B inhibitors which would prove to be a milestone for the management of diabetes (Medicinal Research Reviews)

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