National Diabetes Inpatient Audit 2011
Key findings – Hospital Level Analysis for England – Hospital Level Analysis for Wales – Presentation of Results (Health and Social Care Information Centre)
Variation in the recorded incidence of amputation of the lower limb in England
Variation in amputation incidence occurs across England. Because of the similarity in amputation variation between people with and without diabetes the variation may reflect generic differences in local healthcare delivery, although racial factors may also contribute (Diabetologia)
WHO guidance for the use of HbA1c in the diagnosis of diabetes
Abbreviated Report of a WHO Consultation
Pharmacy effect on adherence to antidiabetic medications
The results suggest significant variation in medication adherence attributable to pharmacy factor, independent of other effects. The underlying reason could be varying level of influence from pharmacies’ efforts to inform or influence patients to take medications in prescribed manners (Medical Care)
Type 2 diabetes managed by diet and lifestyle: HbA1c can identify significant post-prandial hyperglycaemia
Even volunteers with reasonably well-controlled, diet-managed type 2 diabetes spent a large proportion (9/24 hours) of the day with glucose concentrations in excess of 8mmol/L, suggesting that implementation of the IDF guidelines presents a challenge in normal clinical practice (Practical Diabetes)
Persistence of Prolonged C-peptide Production in Type 1 Diabetes as Measured With an Ultrasensitive C-peptide Assay
The ultrasensitive assay revealed that C-peptide production persists for decades after disease onset and remains functionally responsive. These findings suggest that patients with advanced disease, whose ß-cell function was thought to have long ceased, may benefit from interventions to preserve ß-cell function or to prevent complications (Diabetes Care)
Spectrum of congenital anomalies in pregnancies with pregestational diabetes
The increased risk of congenital anomalies in pregnancies with pregestational diabetes is related to specific non-chromosomal congenital anomalies and multiple congenital anomalies and not a general increased risk (Birth Defects Research)
Gestational diabetes and cardiovascular risk factors in the offspring: Results from a cross-sectional study
Gestational diabetes mellitus does not appear to have a relevant effect on cardiovascular disease correlates such as blood pressure or cholesterol levels in children, and the potential effect of gestational diabetes mellitus on body composition seems to be widely explainable by maternal BMI (Diabetic Medicine)
Efficacy of endoluminal interventional therapy in diabetic peripheral arterial occlusive disease: a retrospective trial
With a low risk of morbidity and mortality, the percutaneous revascularization accepted by patients does not affect ultimate necessary surgical revascularization and consequently should be considered as the preferred therapy for chronic lower extremity ischemia. The efficacy and prognosis of interventional therapy in diabetic patients is similar that in non-diabetic patients (Cardiovascular Diabetology)
Applicability of a Combination of Hemoglobin A1c and Fasting Plasma Glucose in Population-based Prediabetes Screening
The enhanced prevalence of prediabetes using HbA1c+FPG compared with FPG+2hPG calls for the need to redefine at a more basic and a more practical level how to apply HbA1c in screening for prediabetes. A redefined HbA1c that incorporates FPG, age, race/ethnicity and BMI may put forward a better way to use HbA1c in population-based and clinical settings (Journal of Diabetes)
Arterial Stiffness Is Increased in Patients With Type 1 Diabetes Without Cardiovascular Disease
Arterial stiffness assessed as aPWV is increased in patients with type 1 diabetes without clinical cardiovascular disease, independently of classical cardiovascular risk factors. In men with type 1 diabetes, low-grade inflammation is independently associated with arterial stiffness (Diabetes Care)
Mechanisms for Insulin Resistance: Common Threads and Missing Links
Evidence presented in this Review suggests that ectopic lipid (diacylglycerols and possibly ceramides) may be at the root cause of liver and muscle insulin resistance and that new therapies aimed at decreasing lipid content in these organs will represent the most efficacious therapeutic targets for the treatment of insulin resistance and its associated comorbidities (Cell)
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