Diabetes News October 29th 2010

Sponsorship appeal for 2011
The editorial team of Glycosmedia would welcome offers of sponsorship to help fund the publication of this free diabetes news bulletin during 2011. From January 2011 (as part of the sponsorship deal) it will be possible to feed the Glycosmedia diabetes news listing directly into your website. For further information please contact jim@glycosmedia.com

Safer administration of insulin
Summary of a safety report from the National Patient Safety Agency (BMJ)

Safer administration of insulin
All organisations in the NHS and independent sector should ensure that: (NHS – National Patient Safety Agency)

2nd Annual Diabetes and Diabetic Retinopathy conference
Visiongain’s 2nd Annual Diabetes and Diabetic Retinopathy conference is designed to bring together the industry experts to discuss every aspect of drug development for diabetes, from latest clinical development through to dealing with regulatory issues (Visiongain)

Making news relevant
Why should a pharmaceutical company outsource a therapy-specific news service? Article by Jim Young, editor-in-chief of Glycosmedia (PMLive)

Coronary heart Disease Statistics 2010
Chapter 5 details the prevalence of medical risk factors for CHD (raised blood pressure, raised cholesterol, overweight and obesity, diabetes (Heart Stats)

Diabetes and the platelet: Toward new therapeutic paradigms for diabetic atherothrombosis
There is converging evidence that MPs and MP-associated TF activity are upregulated in patients with diabetes mellitus and can participate actively in promoting atherothrombotic complications. In this context, drugs that may reduce the release of microparticles and/or their thrombogenic capacity has the potential to improve upon current antiplatelet therapy, possibly resulting in lower adverse events rates in diabetic individuals (Atherosclerosis)

Diabetes in the UK increases to 2.8 million
The figure for diabetes prevalence in the UK in 2010 comes as a result of figures from The Quality and Outcomes Framework (QOF) which many GP surgeries take part in (DRWF)

Projection of the year 2050 burden of diabetes in the US adult population
Dynamic modeling of incidence, mortality, and prediabetes prevalence (Population Health Metrics)

Disruption of HGF/c-met Signaling Enhances Pancreatic Beta Cell Death and Accelerates the Onset of Diabetes
These results show that HGF/c-met is critical for beta cell survival by attenuating NFkB signaling and suggest that activation of the HGF/c-met signaling pathway represents a novel strategy for enhancing beta cell protection (Diabetes)

Liraglutide in the management of type 2 diabetes
Liraglutide has the potential to acquire an important role, not only in the treatment of type 2 diabetes, but also in preservation of ß-cell function, weight loss, and prevention of chronic diabetic complications (Drug Design, Development and Therapy)

Predictors of responsiveness to insulin therapy in type 2 diabetes are identified
The study identified predictors of insulin responsiveness among patients with type 2 diabetes that could help clinicians in deciding for or against insulin therapy initiation (American Diabetes Association)

Macrovascular Disease in Elderly Patients with Diabetes
The macrovascular complications of diabetes are the main cause of morbidity and mortality in elderly patients with diabetes. Though there are limited studies devoted to studying these as well as their treatment in the elderly population, some information from studies of younger populations can be extrapolated (Clinical Geriatrics)

Managing diabetic retinopathy
We searched Medline and Embase with the keywords “diabetic macular oedema”, “diabetic maculopathy”, “diabetic retinopathy”, and “controlled clinical trials”. We used evidence from published abstracts from major international scientific meetings and from the UK National Institute for Health and Clinical Excellence (Abstract, BMJ)

Prospective Study Reveals Associations Between Colorectal Cancer and Type 2 Diabetes Mellitus or Insulin Use in Men
There is a modest association between type 2 DM and CRC among men, but not women. Insulin use is not associated with a substantially increased risk of CRC (Gastroenterolgy)

Chronic kidney disease NICE consultation
With background documents and comments proforma. The consultation period will end at 5pm on 10th November 2010 (NICE)

Relationship between ulcer healing after hyperbaric oxygen therapy and transcutaneous oximetry, toe blood pressure and ankle–brachial index – diabetes and chronic foot ulcers
Our results indicate that TcPO2 in contrast to ABI and TBP correlates to ulcer healing following HBOT. We suggest HBOT as a feasible adjunctive treatment modality in diabetic patients with chronic non-healing foot ulcers when basal TcPO2 at the dorsum of the foot is above 25 mmHg (Diabetologia)