FDA significantly restricts access to the diabetes drug Avandia
The U.S. Food and Drug Administration today announced that it will significantly restrict the use of the diabetes drug Avandia (rosiglitazone) to patients with Type 2 diabetes who cannot control their diabetes on other medications (FDA)
Avandia – Message from Dr Ellen Strahlman, Chief Medical Officer – GSK
If you are a patient in Europe currently taking any of these medicines, you should contact your physician at the earliest opportunity to discuss switching to alternative treatment options (GSK)
All people with diabetes should be on statins
That is the conclusion in a press release from the EASD annual meeting (EASD)
NICE consults on the management of diabetic foot problems
NICE hasopened a consultation (20 September 2010) on its draft guidelines for the care of people with diabetic foot problems in hospita (NICE)
The Optimized Evaluation of Diabetic Foot Infection by Dual Isotope SPECT/CT Imaging Protocol
DI SPECT/CT is a highly accurate modality that considerably improves detection and discrimination of STI and OM while providing precise anatomic localization in the diabetic foot (Journal of Foot and Ankle Surgery)
Inflammatory Mediators and Glucose in Pregnancy
Results from a Subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study (Journal of Clinical Endocrinology & Metabolism)
New clue to diabetic heart disease discovered
Scientists from King’s College London have identified a molecule that could help predict type 2 diabetes and identify diabetics that are most vulnerable to heart and circulatory disease (King’s College London)
Participatory Decision Making, Patient Activation, Medication Adherence, and Intermediate Clinical Outcomes in Type 2 Diabetes: A STARNet Study
Participatory decision making during primary care encounters by patients with type 2 diabetes resulted in improvements in hemoglobin A1c levels and LDL cholesterol values by improving patient activation, which in turn improved medication adherence (Annals of Family Medicine)
Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase-I function
We have identified a novel mechanism by which candesartan improves diabetic retinopathy through the restoration of GLO-I (Diabetes)
Gastric mucosal nerve density
In this observational study, gastric mucosal nerves were abnormal in patients with type 1 diabetes with secondary complications and clinical evidence of gastroparesis. Gastric mucosal biopsy is a safe, practical method for histologic diagnosis of gastric autonomic neuropathy (American Academy of Neurology)
Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes
Insulin resistance may be a marker of AD risk that is associated with reduced CMRglu and subtle cognitive impairments at the earliest stage of disease, even before the onset of mild cognitive impairment (Archives of Neurology)
Progression of brain atrophy and cognitive decline in diabetes mellitus
Our data show that elderly patients with DM without dementia have accelerated progression of brain atrophy with significant consequences in cognition compared to subjects without DM. Our findings add further evidence to the hypothesis that diabetes exerts deleterious effects on neuronal integrity (Neurology)
The use of eGFR and ACR to predict decline in renal function in people with diabetes
This study demonstrates that the progression of kidney disease in diabetic people without albuminuria is relatively benign compared with those with albuminuria (Nephrology Dialysis Transplantation)
Dapagliflozin
24-Week Phase 3 Study Found Investigational Drug Dapagliflozin Improved Glycosylated Hemoglobin (HbA1c) When Added to Glimepiride in Adults with Type 2 Diabetes Mellitus (PharmaLive)
Lixisenatide
Investigational Compound Once-Daily Lixisenatide Demonstrated Significant Improvement in Glucose Control in Patients With Type 2 diabetes (PharmaLive)
Webcasts – Charting a new course in Type 2 diabetes
Linagliptin is an investigational compound and not approved for clinical use (Boehringer Ingelheim)
FDA significantly restricts access to the diabetes drug Avandia
The U.S. Food and Drug Administration today announced that it will significantly restrict the use of the diabetes drug Avandia (rosiglitazone) to patients with Type 2 diabetes who cannot control their diabetes on other medications (FDA)
Avandia – Message from Dr Ellen Strahlman, Chief Medical Officer – GSK
If you are a patient in Europe currently taking any of these medicines, you should contact your physician at the earliest opportunity to discuss switching to alternative treatment options (GSK)
All people with diabetes should be on statins
That is the conclusion in a press release from the EASD annual meeting (EASD)
NICE consults on the management of diabetic foot problems
NICE hasopened a consultation (20 September 2010) on its draft guidelines for the care of people with diabetic foot problems in hospita (NICE)
The Optimized Evaluation of Diabetic Foot Infection by Dual Isotope SPECT/CT Imaging Protocol
DI SPECT/CT is a highly accurate modality that considerably improves detection and discrimination of STI and OM while providing precise anatomic localization in the diabetic foot (Journal of Foot and Ankle Surgery)
Inflammatory Mediators and Glucose in Pregnancy
Results from a Subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study (Journal of Clinical Endocrinology & Metabolism)
New clue to diabetic heart disease discovered
Scientists from King’s College London have identified a molecule that could help predict type 2 diabetes and identify diabetics that are most vulnerable to heart and circulatory disease (King’s College London)
Participatory Decision Making, Patient Activation, Medication Adherence, and Intermediate Clinical Outcomes in Type 2 Diabetes: A STARNet Study
Participatory decision making during primary care encounters by patients with type 2 diabetes resulted in improvements in hemoglobin A1c levels and LDL cholesterol values by improving patient activation, which in turn improved medication adherence (Annals of Family Medicine)
Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase-I function
We have identified a novel mechanism by which candesartan improves diabetic retinopathy through the restoration of GLO-I (Diabetes)
Gastric mucosal nerve density
In this observational study, gastric mucosal nerves were abnormal in patients with type 1 diabetes with secondary complications and clinical evidence of gastroparesis. Gastric mucosal biopsy is a safe, practical method for histologic diagnosis of gastric autonomic neuropathy (American Academy of Neurology)
Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes
Insulin resistance may be a marker of AD risk that is associated with reduced CMRglu and subtle cognitive impairments at the earliest stage of disease, even before the onset of mild cognitive impairment (Archives of Neurology)
Progression of brain atrophy and cognitive decline in diabetes mellitus
Our data show that elderly patients with DM without dementia have accelerated progression of brain atrophy with significant consequences in cognition compared to subjects without DM. Our findings add further evidence to the hypothesis that diabetes exerts deleterious effects on neuronal integrity (Neurology)
The use of eGFR and ACR to predict decline in renal function in people with diabetes
This study demonstrates that the progression of kidney disease in diabetic people without albuminuria is relatively benign compared with those with albuminuria (Nephrology Dialysis Transplantation)
Dapagliflozin
24-Week Phase 3 Study Found Investigational Drug Dapagliflozin Improved Glycosylated Hemoglobin (HbA1c) When Added to Glimepiride in Adults with Type 2 Diabetes Mellitus (PharmaLive)
Lixisenatide
Investigational Compound Once-Daily Lixisenatide Demonstrated Significant Improvement in Glucose Control in Patients With Type 2 diabetes (PharmaLive)
Webcasts – Charting a new course in Type 2 diabetes
Linagliptin is an investigational compound and not approved for clinical use (Boehringer Ingelheim)
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