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Diabetes News September 30th 2008

September 30th 2008

Getting to the bottom of NHS diabetes care
Diabetes is on the rise and is estimated to be responsible for more than one in 10 deaths in England – so why are more GPs not detecting and monitoring it? (Heath Service Journal, UK)

The clinical effectiveness of diabetes education models for Type 2 diabetes: a systematic review
Based on the evidence reviewed in this report, it would seem that education delivered by a team of educators, with some degree of reinforcement of that education made at additional points of contact, may provide the best opportunity for improvements in patient outcomes (Health Technology Assessment, UK)

International Diabetes Federation launches diabetes awareness campaign
The International Diabetes Federation is calling on groups and individuals worldwide to get involved in activities to raise awareness of diabetes leading up to World Diabetes Day on November 14. The theme for this year’s campaign is “Diabetes in Children and Adolescents.” (MTB, Europe)

Exercise or exercise and diet for preventing type 2 diabetes mellitus
Interventions aimed at increasing exercise combined with diet are able to decrease the incidence of type 2 diabetes mellitus in high risk groups – people with impaired glucose tolerance or the metabolic syndrome (Cochrane Reviews)

Creator of Glucose Measurement Technology Used In Abbott’s Diabetes Care Products Receives National Medal of Technology and Innovation
Professor Adam Heller’s Wired Enzyme(TM) Technology used in Abbott’s FreeStyle Blood Glucose Monitoring(R) and FreeStyle Navigator(R) Continuous Glucose Monitoring Systems (Market Watch)

The California Diabetes Program and other outstanding public health programs are in great danger
On September 23, 2008 the Governor signed the budget. It was 84 days late. Unfortunately, the Executive Order that was initiated on July 31 that suspended all state contracts was not lifted with the signing of the budget (Diabetes Health, USA)

Beneficial Effects of Insulin on Glycemic Control and ß-Cell Function in Newly Diagnosed Type 2 Diabetes With Severe Hyperglycemia After Short-Term Intensive Insulin Therapy
A 6-month course of insulin therapy, compared with OAD treatment, could more effectively achieve adequate glycemic control and significant improvement of ß-cell function in new-onset type 2 diabetic patients with severe hyperglycemia (Diabetes Care)

Timing Is Everything: Age of Onset Influences Long-Term Retinopathy Risk in Type 2 Diabetes, Independent of Traditional Risk Factors
These data suggest an increased inherent susceptibility to diabetic retinopathy with earlier-onset type 2 diabetes. This further supports the importance of delaying development of diabetes and also implies a need for more stringent metabolic targets for younger individuals (Diabetes Care)

Effectiveness of continuous glucose monitoring in pregnant women with diabetes: randomised clinical trial
Continuous glucose monitoring during pregnancy is associated with improved glycaemic control in the third trimester, lower birth weight, and reduced risk of macrosomia (BMJ, UK)

Liraglutide improves glucose control, increases weight loss
Novo Nordisk has been boosted by the publication of positive data from a late-stage trial comparing the Danish firm’s investigational diabetes drug liraglutide with Sanofi-Aventis’ Amaryl (PharmaTimes)

Facing today’s challenges in diabetes education
Access to care is one problem facing diabetes education; solutions are out there, according to some educators (Endocrine Today)

Conceptual Model of Symptom-Focused Diabetes Care for African Americans
The symptom-focused conceptual model is an innovative approach to tailoring care to a distinct population and to engaging participants in their own self-care (redOrbit, USA)

The genetics of type 2 diabetes: a realistic appraisal circa 2008
While substantial progress in our knowledge of the genetic basis of type 2 diabetes is taking place, these new discoveries represent but a small proportion of the genetic variation underlying the susceptibility to this disorder (Journal of Clinical Endocrinology & Metabolism)

Delivering Performance Improvement Findings from DiabetesE
Third National Report. 91-page PDF (Innove, UK)

Next National DiabetesE Report
If your PCT has yet to use DiabetesE or would like some support for undertaking a DiabetesE assessment, please contact Barbara Wright (Innove, UK)

Health Experts Call for New Strategies to Combat Alarming Rise in Diabetes
Johnson & Johnson Diabetes Institute Launched as New Research Suggests Improved Patient Education May Play Key Role in Halting Escalating Disease in the EMEA Region (Market Watch)

New guidelines for blood donors
Diabetes UK welcomes a change in blood service guidelines allowing some people with Type 2 diabetes to now donate blood if they wish to (Diabetes UK )

Controlling blood glucose and reducing the risk of cardiovascular disease in type 2 diabetes
Guidelines and performance measures should be based on the best available evidence and highlight strategies that benefit patients. For type 2 diabetes, this means using interventions that not only reduce blood glucose levels, but are also proven to reduce the risk of cardiovascular (CV) events and/or improve wellbeing (NPC, MeReC, NHS, UK)

American Diabetes Association Celebrates Historic Victory for Americans With Disabilities
President Bush Signs Landmark Civil Rights Legislation Into Law (Market Watch)

Bringing diabetes to light: encouraging citizens to raise awareness and protect future generations
Theme for 2008 World Diabetes Day – November 14 – is “Diabetes in Children and Adolescents” (International Diabetes Federation)

New Diabetes Drug Works Well in Trial
The drug, liraglutide, is a laboratory-made version of glucagon-like peptide-1 (GLP-1), a hormone produced by the body (Washington Post, USA)

Array BioPharma Presents Positive Preclinical Data on Its Glucokinase Activators in Type 2 Diabetes
The data showed that ARRY-403 (a novel small molecule glucokinase activator) demonstrated potent, highly glucose-blood-level dependent, control of both fasting and non-fasting glucose concentrations. Based on these and other results, Array plans to advance ARRY-403 into human clinical studies in the first half of 2009 (Market Watch)

Takeda files alogliptin/Actos diabetes combo with FDA
Takeda Pharmaceutical Co has submitted a New Drug Application to US regulators to get marketing approval for its new dipeptidyl peptidase-4 inhibitor SYR-322 and the blockbuster Actos combined in a single tablet for the treatment of type 2 diabetes (PharmaTimes)

Clean homes and diabetes risk
These results have been over-interpreted by the newspapers. It is not yet clear to what extent these genetically modified mice are representative of the development of an autoimmune condition such as diabetes in humans (Behind the Headlines, NHS Choices, UK)

Monogenic Diabetes
The National Diabetes Support Team have published the first in the new series of “Diabetes Bulletin” … The first of these bulletin’s looks at Monogenic Diabetes which is caused by a change in a single gene and affects 20,000 – 40,000 people in the UK (National Library for Health)

Parental obsessions with cleanliness can lead to diabetes in children
Children who are brought up in extremely clean houses could be at greater risk of developing diabetes later in life, scientists have warned (Telegraph, UK)

Takeda seeks U.S. approval of type 2 diabetes drugs
Takeda Pharmaceutical Co said on Wednesday it had applied for approval to market in the United States the SYR-322 and the Actos diabetes drugs in a single tablet for the treatment of type 2 diabetes (Guardian, UK)

Glycemic Control in Diabetic CKD Patients: Where Do We Stand?
By reviewing the relevant literature, we argue that glycemic control can still be beneficial in preventing complications, even in dialysis-dependent patients, but there is need for a much better understanding of the CKD-related characteristics of DM (American Journal of Kidney Diseases)

Insulin sensitivity, VO2max and body composition in severely obese Swedish children and adolescents
Relative (BM) VO2max and relative (FFM) VO2max were stronger predictors of SI than percent body fat in severely obese children and adolescents (Acta Pædiatrica)

Internet program helps people with diabetes monitor sugar
An Internet-based blood-sugar monitoring program appears to help people with type 1 diabetes better manage their condition, researchers report (BD Diabetes, USA)

Anxious folks may spot diabetes symptoms early
Being anxious may be good for your health, at least if you have risk factors for type 2 diabetes, new research shows (MedlinePlus)

Trial to help prevent complications for adolescents with Type 1 diabetes
Researchers at the University of Cambridge are working with funding from Diabetes UK, the Juvenile Diabetes Research Foundation and the British Heart Foundation to set up a five year international study to try and prevent heart and kidney disease in young people with Type 1 diabetes (Diabetes UK)

Intensive control in type-1 diabetes reduces long-term hypertension risk
Long-term follow-up data from a landmark trial indicates that intensive glycaemic control reduces the risk of long-term hypertension compared to conventional control (National electronic Library for Medicines)

Self-monitoring of blood glucose (SMBG) and glycaemic control in type 2 diabetes
The use of SMBG was not associated with improved glycaemic control in any therapy category of patients with type 2 diabetes in primary care (Scandinavian Journal of Primary Health Care )

Trouble reading may contribute to poor glycemic control
Taking diabetes medication doses more than twice a day and having trouble reading the medication prescription label were factors associated with poorly controlled diabetes, according to a recent study from the University of Washington in Seattle (Endocrine Today)

Glucose cut-off point for defining hypoglycaemia
Changing the glucose cut-off values that define hypoglycaemia has a major effect on reported frequencies of hypoglycaemia (Diabetologia)

Low Bone Density Persists in Women with Diabetes
The results of a study published in Diabetes Care confirm that young women with type 1 diabetes have lower bone mineral densities (BMD) than young women without the disease (American Diabetes Association)

Low Fat, Low Carb, or Mediterranean?
Fad diets often run their course and disappear from popularity as people lose, then regain. But three diets seem to be the most generally accepted. Diet debate video (Voice of America)

Nasal Insulin Won’t Shield At-Risk Kids From Diabetes
Nasally administered insulin won’t protect children at high risk of developing type 1 diabetes from getting the illness, Finnish researchers say (Washington Post)

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