Effect of Diabetes on the Fracture Resistance of Bone

The general concept is that increases in AGEs within the matrix cause the collagen phase to become brittle, reducing the capacity of the tissue to resist the formation and propagation of microdamage. While certainly more research into the diabetic effects on fracture resistance is necessary before clear therapeutic options are identified, diabetes should be considered a problem of bone brittleness, not just one of low bone strength (Clinical Reviews in Bone and Mineral Metabolism)