Modeling of 24-Hour Glucose and Insulin Profiles T2D Treated With Biphasic Insulin Aspart

Circadian variations in glucose homeostasis were assessed on relevant parameters, and a significant improvement was achieved by including a circadian rhythm on the endogenous glucose production in the model. The extended model is a useful tool for clinical trial simulation and for elucidating the effect profile of new insulin products (Journal of Clinical Pharmacology)