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Diabetes News

Category: Cardiovascular


Predictive models for all-cause and cardiovascular mortality in type 2 diabetic inpatients. A cohort study

October 13th 2014

This study provides tools to predict premature mortality in type 2 diabetic inpatients (International Journal of Clinical Practice)

Categories: Cardiovascular, News

Categories: Cardiovascular

The effects of intravenous insulin infusions on early mortality for patients with acute coronary syndromes who present with hyperglycaemia: A matched propensity analysis using data from the MINAP database 2008–2012

October 1st 2014

As used in current clinical practice to treat hyperglycaemia in acute coronary syndromes, IVII appears to be of benefit only for patients with STEMI who are not known to have diabetes. IVII is associated with adverse early outcomes in patients with NSTEMI (European Heart Journal – Cardiovascular Care)

Categories: Cardiovascular, News

Categories: Cardiovascular

Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes

September 25th 2014

The benefits with respect to mortality that had been observed among patients originally assigned to blood-pressure–lowering therapy were attenuated but still evident at the end of follow-up. There was no evidence that intensive glucose control during the trial led to long-term benefits with respect to mortality or macrovascular events (NEJM)

Categories: Cardiovascular, News

Categories: Cardiovascular

Plasma Triglycerides Predict Incident Albuminuria and Progression of Coronary Artery Calcification in Adults with Type 1 Diabetes: the Coronary Artery Calcification in Type 1 Diabetes Study

September 23rd 2014

In adults with type 1 diabetes, fasting TG independently predicted cardiorenal disease over 6 years and improved reclassification of risk by conventional risk factors (Journal of Clinical Lipidology)

Categories: Cardiovascular, News

Categories: Cardiovascular

Incretin-Based Drugs and the Risk of Congestive Heart Failure

September 10th 2014

In our population-based study, incretin-based drug use was not associated with an increased risk of CHF among patients with type 2 diabetes (Diabetes Care)

Categories: Cardiovascular, News

Categories: Cardiovascular

Hemoglobin A1c less than 6.5% on admission increases risk for in-hospital and 1-year mortality in patients with diabetes and chest pain

September 2nd 2014

Patients with diabetes admitted for chest pain with HbA1c less than 6.5% may be at increased risk for in-hospital and 1-year mortality. The mechanism for death may be mediated in part by hypoglycemia (Cardiovascular Endocrinology)

Categories: Cardiovascular, News

Categories: Cardiovascular

Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure

August 30th 2014

In this study 34% of the participants had diabetes, Results: LCZ696 was superior to enalapril in reducing the risks of death and of hospitalization for heart failure (NEJM)

Categories: Cardiovascular, News

Categories: Cardiovascular

Peripheral neuropathy and the risk of cardiovascular events in type 2 diabetes mellitus

August 28th 2014

PN is associated with increased risk for a first cardiovascular event among individuals with diabetes (Heart)

Categories: Cardiovascular, News

Categories: Cardiovascular

Hemoglobin A1c, comorbid conditions and all-cause mortality in older patients with diabetes: A retrospective 9-year cohort study

August 25th 2014

In our patient population, HbA1c scores

Categories: Cardiovascular, News

Categories: Cardiovascular

Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies

August 22nd 2014

Metformin use was associated with a decreased risk of AF in patients with type 2 DM who were not using other anti-diabetic medication, probably via attenuation of atrial cell tachycardia-induced myolysis and oxidative stress (Cardiovascular Diabetology)

Categories: Cardiovascular, News

Categories: Cardiovascular

Development of a New Diabetes Risk Prediction Tool for Incident Coronary Heart Disease Events

August 14th 2014

This new CHD risk estimator has better discriminative ability for incident CHD than the FRS, UKPDS, and the ATP III/NCEP recommendations in a multi-ethnic cohort with T2DM (Atherosclerosis)

Categories: Cardiovascular, News

Categories: Cardiovascular

Low dose of acetylsalicylic acid and oxidative stress-mediated endothelial dysfunction in diabetes: a short-term evaluation

August 11th 2014

Our findings suggest that ASA utilization for primary prevention in diabetic patients causes a significant increase of oxidative stress burden impairing the vascular function. Present data, if confirmed on a larger population, could permanently discourage the use of the ASA for the primary prevention in patients with DM (Acta Diabetologica)

Categories: Cardiovascular, News

Categories: Cardiovascular

Blood pressure and heart failure risk among diabetic patients

July 28th 2014

The current study suggests a U-shaped association between observed BP and the risk of HF among diabetic patients (International Journal of Cardiology)

Categories: Cardiovascular, News

Categories: Cardiovascular

Sitagliptin Use in Patients With Diabetes and Heart Failure

July 3rd 2014

Sitagliptin use was not associated with an increased risk of all-cause hospitalizations or death, but was associated with an increased risk of HF-related hospitalizations among patients with T2D with pre-existing HF (JACC)

Categories: Cardiovascular, News

Categories: Cardiovascular

Association Between Impaired Cardiovascular Autonomic Function and Hypoglycemia in Patients With Type 1 Diabetes

June 30th 2014

Increased GV promoting hypoglycemic stress was associated with reduced HRV independent of glycemic control as assessed by HbA1c. These pilot data suggest that glucose variability may contribute to cardiovascular autonomic dysfunction among adults with type 1 diabetes (Diabetes Care)

Categories: Cardiovascular, News

Categories: Cardiovascular

Dietary Fat Composition and Cardiac Events in Patients with Type 2 Diabetes

June 30th 2014

In patients with type 2 diabetes without ischemic heart disease, a high intake of polyunsaturated fatty acids, especially alpha linolenic acid, was protective for the development of cardiac events (Atherosclerosis)

Categories: Cardiovascular, News

Categories: Cardiovascular

Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation

June 15th 2014

Myocardial copper deficiency and defective cellular copper transport/trafficking are revealed as key molecular defects underlying LV impairment in diabetes, and TETA-mediated restoration of copper regulation provides a potential new class of therapeutic molecules for DCM (Cardiovascular Diabetology)

Categories: Cardiovascular, News

Categories: Cardiovascular

Plasma advanced glycation endproducts are associated with incident cardiovascular events in individuals with type 2 diabetes: a case-cohort study with a median follow-up of 10 years (EPIC-NL)

May 23rd 2014

High plasma AGEs were associated with incident cardiovascular events in individuals with T2DM. These results underline the potential importance of AGEs in development of CVD (Diabetes)

Categories: Cardiovascular, News

Categories: Cardiovascular

Intensified insulin-based glycaemic control after myocardial infarction

May 13th 2014

Intensified insulin-based glycaemic control after acute myocardial infarction in patients with diabetes and hyperglycaemia at admission had a long-lasting effect on longevity (The Lancet Diabetes & Endocrinology)

Categories: Cardiovascular, News

Categories: Cardiovascular

Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes

May 5th 2014

This study suggests that calpain may play a role in vascular endothelial cell ROS production and endothelium-dependent dysfunction in diabetes. Thus, calpain may be an important therapeutic target to overcome diabetes-induced vascular dysfunction (Cardiovascular Diabetology)

Categories: Cardiovascular, News

Categories: Cardiovascular
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