Diabetes News

The retinal vascular fractal dimension is a shared biomarker of diabetic microvasculopathy, thus indicating a possible common pathogenic pathway. Retinal fractal analysis therefore is a potential tool for risk stratification in type 1 diabetes (Diabetologia)

Serum OPN is a strong predictor of incipient diabetic nephropathy, a first-ever CVD event, and all-cause mortality in patients with T1D. Serum OPN may be of clinical significance for the risk prediction of CVD events in patients with T1D (Diabetes Care)

In its new document, the American Diabetes Association called for an A1c target of less than 7.5% for all under 18s, bringing its recommendations into line with those of the International Society for Pediatric and Adolescent Diabetes, the Pediatric Endocrine Society, and the International Diabetes Federation (BMJ)

This approach identified autoantibodies that can provide a new dimension of information indicative of T1DM independent of GADA and new insights into diagnosis and classification of T1DM (Diabetes)

A mean HbA1c difference of 5 mmol/mol (0.5%) across the mean cell haemoglobin concentration reference range suggests that an accompanying full blood count examination may be required for its use in the diagnosis of diabetes (Diabetic Medicine)

Serum bilirubin concentrations within the physiological range were positively associated with serum C-peptide levels in patients with Type 2 diabetes (Diabetic Medicine)

This large-scale cohort study provided evidence that high baPWV is a useful independent predictor of mortality and cardiovascular morbidity in subjects with diabetes (Diabetes Care)

Increases in HbA1c from one to five years post-diagnosis were independently associated with increased odds of reporting a negative impact of diabetes on QoL (Diabetes/Metabolism Research and Reviews)

PV is reduced in Type 2 DM compared to normoglycemic individuals and can be measured using MRI without contrast injection (Pancreatology)

These results suggest that HbA1c values may be potentially useful not only to indicate long-term glycemic control to indicate onset of complications at a clinically detectable level and molecular level (Diabetes Research and Clinical Practice)

These results show that a stimulated C-peptide response can be measured in some people with long-term Type 1 diabetes (Diabetic Medicine)

Appropriate use of REAL-Time CGM improved glyco-metabolic control in T1D patients. The effects of CGM were more evident in patients under MDI treatment, compared to CSII. Glucose variability, in addition to glycaemic control, was improved in compliant diabetic patients. This article is protected by copyright (Diabetes/Metabolism Research and Reviews)

It is the responsibility of diabetes specialists to ensure that people with diabetes are equipped with the knowledge to use self-monitoring more effectively (Diabetologia)

cFLC elevation is a novel marker for CVD outcomes in type 2 diabetes that warrants further investigation (Diabetes Care)

Baseline TG level of prediabetic subjects appeared to be associated with rate of change in insulinogenic index and disposition index over a 2-year period, indicating that TG levels among prediabetic subjects should be carefully monitored (Annals of Nutrition and Metabolism)

Baseline TG level of prediabetic subjects appeared to be associated with rate of change in insulinogenic index and disposition index over a 2-year period, indicating that TG levels among prediabetic subjects should be carefully monitored (Annals of Nutrition and Metabolism)

Circulating NT-proBNP was associated with a measure of insulin sensitivity before and during preventive interventions for type 2 diabetes in the DPP (Diabetologia)

Combined with the known faster kinetics of IP insulin delivery over SQ delivery, our findings suggest that artificial pancreas technologies may be optimized by both sensing glucose and delivering insulin in the IP space (Diabetes)

MVs contribute to the development of diabetic macrovascular and microvascular complications. In addition, clinical studies have indicated that changes in MV number and composition may reflect the pathophysiological conditions of disease, and therefore, may serve as potential biomarkers for diagnostic and prognostic use (Acta Pharmacologica Sinica)

These data suggest that ‘diabetes autoimmunity’, as reflected by GAD antibodies and insulinoma-associated-2 autoantibodies, in middle-aged individuals at risk for diabetes is not a clinically relevant risk factor for progression to diabetes (Diabetic Medicine)