Diabetes News

Severe hypoglycemia was common among patients with type 2 diabetes across all levels of glycemic control. Risk tended to be higher in patients with either near-normal glycemia or very poor glycemic control (Diabetes Care)

this T2D-IFG biomarker study has surveyed the broadest panel of non-targeted metabolites to date, revealing both novel and known associated metabolites and providing potential novel targets for clinical prediction and a deeper understanding of causal mechanisms (Diabetes)

Only inpatient blood glucose monitoring system among leading hospital brands to use individually foil-wrapped test strips, helping reduce risk of test strip cross-contamination (Abbott)

F-CPI was correlated only with unadjusted indexes of insulin secretion, whereas PP-CPI was correlated with such indexes as well as with those adjusted for insulin sensitivity. The better clinical utility of PP-CPI might be attributable to these physiological characteristics (Metabolism)

The present findings suggest that an HbA1c target of less than 6.5% or 48 mmol/mol might be too low for some patients and large reductions, or increases, in HbA1c levels should be approached cautiously. The findings also point to potential age-related differences in HbA1c levels and mortality rates with younger diabetes patients being at relatively greater risk of mortality associated with low HbA1c levels even though absolute risks are smaller at young ages (PLoS ONE)

The urinary C-peptide creatinine ratio is a practical non-invasive method to aid detection of absolute insulin deficiency, with a urinary C-peptide creatinine ratio > 0.2nmol/mmol being a reliable indicator of retained endogenous insulin secretion (Diabetic Medicine)

In subjects with impaired glucose regulation, HDL-C levels are associated with indices of beta-cell dysfunction; thus, more attention, it should be deserve to HDL-C concentrations in IFG/IGT patients due their potential conversion to DM2 (Acta Diabetologica)

Responding to SMBG test results and increased testing frequency were not associated with improved glycaemic control in the short-term. There is a lack of knowledge surrounding SMBG in non-insulin treated patients (Diabetes Research and Clinical Practice)

Lower proportion of type I fibers in metabolic syndrome muscle correlated with the severity of insulin resistance. Even though whole muscle content was normal, key elements of insulin action were consistently less in type I muscle fibers, suggesting their distribution was important in mediating insulin effects (Journal of Clinical Endocrinology & Metabolism)

Changes in immunity seen in individuals with high risk of developing T1D points to alterations/actions in the immune system already early in the pre-diabetic phase (Diabetes Research and Clinical Practice)

The study aimed to investigate the impact of a delay of 12h between sample collection and HbA1c measurement. We propose an easy method to determine the adequacy of removal of HbA1d and in case of insufficient removal suggest measurement of HbA1c 12h after collection (Diabetes Research and Clinical Practice)

The future is in the use of insulin pumps controlled by continuous glucose monitors. This technology is complex and has not yet become standard. The development of future inpatient diabetes care will depend on adaptation of hospital systems to advance the new technology (Expert Review of Endocrinology & Metabolism)

Baseline LBGI predicts the outcome of type 1 diabetic patients who switch to CSII in terms of hypoglycemia (Diabetes Care)

Lumbar spine TBS predicts osteoporotic fractures in those with diabetes, and captures a larger portion of the diabetes-associated fracture risk than BMD(Journal of Clinical Endocrinology & Metabolism)

We found that subjects with diabetes, metabolic syndrome and increased insulin resistance had increased levels of IL6, TNF-a and hs-CRP, while no association was found with IL-1ß. (Clinical Endocrinology)

Plasma YKL-40 concentration is an independent predictor of 10-year all-cause and cardiovascular mortality in subjects with type 2 diabetes. Further investigations on the role of YKL-40 in the pathogenesis of CVD are required to elucidate the underlying mechanisms (Clinical Endocrinology)

The annual variability in GA was greater than that in HbA1c. In addition, the annual variability in HbA1c and that in GA in the T1DM patients were greater than in the T2DM patients. Our findings suggest that GA more accurately reflects long-term variations in PG levels than HbA1c (Diabetes and Its Complications)

A target of HbA1C between 6.0 and 6.5% is appropriate for individuals newly diagnosed with type 2 diabetes without cardiovascular disease. However, a target of

Four kinds of subcutaneous continuous glucose monitoring (CGM) machines have been currently introduced in clinical practice. These machines exhibit real-time glucose on the monitor every 5 minutes and have alarms to indicate hypoglycaemia and hyperglycaemia. However, thus far, there is no clear consensus about the clinical indications for CGM in actual clinical practice (Diabetes/Metabolism Research and Reviews)

The DSQOLS captures the impact of detailed aspects of modern type 1 diabetes management (e.g., carbohydrate counting and flexible insulin dose adjustment) that are now routine in many parts of the U.K. and Ireland. The U.K. English version of the DSQOLS offers a valuable tool for assessing the impact of treatment approaches on QoL in adults with type 1 diabetes (Diabetes Care)