In T2DM subjects whose hyperglycemia is poorly controlled on one or two oral agents, bromocriptine-QR therapy for 24 weeks can provide significant added improvement in glycemic control relative to adding placebo (Endocrine Practice)
Diabetes News
Glycosmedia is dedicated to bringing free, non-promotional, editorially independent news to a global audience about developments in diabetes, and is primarily aimed at health professionals.
Enhanced Absorption of Insulin Aspart – a Dispersed Injection Strategy
A dispersed insulin injection strategy enhanced the effect of a fast-acting insulin analog. The increased surface-to-volume ratio of the subcutaneous insulin depot can facilitate insulin absorption into the vascular system (Diabetes Care)
l-arginine, tetrahydrobiopterin, nitric oxide and diabetes
Restoring proper eNOS activity is key to ameliorating or preventing cardiovascular complications of diabetes. Continued investigation is needed to uncover new means for maintaining endothelial nitric oxide bioavailability (Current Opinion in Clinical Nutrition & Metabolic Care)
Admission and Treatment Factors & Duration of Acidosis in Children
Nongap acidosis was present in many children with prolonged metabolic acidosis. We suggest that a continuous acetate or bicarbonate therapy via maintenance fluid might be beneficial in this subgroup of patients (Pediatric Emergency Care)
Development and psychometric properties of a new social support scale
The findings showed that the designed questionnaire was a valid and reliable instrument for measuring social support for self-care in middle-aged patients with type II diabetes. It is an easy to use questionnaire and contains the most significant diabetes related behaviors that need continuous support for self-care (BMC Public Health)
Assessment of Barriers to Improve Diabetes Management in Older Adults
Only attention between clinic visits lowers diabetes-related distress in older adults. However, communication with an educator cognizant of patients’ barriers improves glycemic control and self-care frequency, maintains functionality, and lowers distress in this population (Diabetes Care)
Performance of Primary Care Physicians on Key Process Measures
PCPs provide better care through higher rates of medication intensification and lifestyle counseling. Covering physicians and midlevel providers may enable more frequent encounters when PCP resources are constrained (Diabetes Care)
Association Urinary Markers of Nucleic Acid Oxidation and Mortality T2D
The RNA oxidation marker 8-oxoGuo is an independent predictor of mortality in patients with established and treated type 2 diabetes, and changes in 8-oxoGuo during the first 6 years after diagnosis are associated with mortality (Diabetes Care)
Effectiveness of gestational diabetes treatment: A systematic review
Treatment of GDM is effective in reducing macrosomia (high quality evidence), preeclampsia and shoulder dystocia. (Diabetes Research and Clinical Practice)
Inpatient diabetes management & improved discharge glycemic control
Inpatient diabetes management (IDMET) substantially improved glycemic control 1 year after discharge in patients newly discharged on insulin; patients previously treated with insulin did not benefit. (Diabetes Research and Clinical Practice)
Impact of Prediabetic Status on Coronary Atherosclerosis
Coronary atherosclerosis and plaque vulnerability were more advanced in prediabetic than in nondiabetic patients and comparable between prediabetic and diabetic patients. Slight or mild disorders in glucose metabolism, such as prediabetes, could be a risk factor for CAD, as is diabetes itself (Diabetes Care)
Retinal Blood Flow and Renal Function T2D & Chronic Kidney Disease
Our results indicated that the vessel diameter and RBF in the retinal arterioles decrease in patients with type 2 diabetes with stage 3 CKD, suggesting that impaired renal function might be associated with decreased RBF, probably via constriction of the retinal arterioles, in early-phase diabetic retinopathy (Diabetes Care)
Dietary Fat Increases Glucose Concentrations and Insulin Requirements in T1D
This evidence that dietary fat increases glucose levels and insulin requirements highlights the limitations of the current carbohydrate-based approach to bolus dose calculation (Diabetes Care)
Experiences of adjusting insulin doses in flexible intensive insulin therapy
While patients are motivated to use flexible intensive insulin therapy, they expressed a need for on-going health professional input, particularly to support adjustment of background insulin doses and mealtime ratios. The need to sustain diary/record keeping should be emphasised to patients and provision of a dedicated glycaemic support service is recommended (Diabetes Research and Clinical Practice)
Closed-Loop Basal Insulin Delivery Over 36 Hours in Adolescents T1D
Day-and-night closed-loop basal insulin delivery can improve glucose control in adolescents. However, unannounced moderate-intensity exercise and excessive prandial boluses pose challenges to hypoglycemia-free closed-loop basal insulin delivery (Diabetes Care)
Can we prevent beta cell apoptosis in type 2 diabetes?
The United Kingdom Prospective Diabetes Study (UKPDS) showed that the progressive character of the disease results from a steady reduction, of approximately 5% per year, in the ability of beta cells to secrete insulin, a process estimated to begin 10 to 12?years before diagnosis, which triggers the onset of diabetes when approximately 50% of beta cell function has been lost (Diabetes/Metabolism Research and Reviews)
Metabolic Programming of MEST DNA Methylation in GDM
Our results support the idea that intrauterine exposure to GDM has long-lasting effects on the epigenome of the offspring. Specifically, epigenetic malprogramming of MEST may contribute to obesity predisposition throughout life (Diabetes)
Effect of Normal Saline and Half NS on Electrolytes in DKA
Hyperchloremia resulting in nonanion gap acidosis can occur and may prolong the duration of insulin infusion and length of PICU stay in patients receiving NS as post-bolus rehydration fluid. Alternatively, the use of half NS may result in a decrease in serum-corrected sodium (Journal of Intensive Care Medicine)
A clinical risk score for heart failure in patients withT2D
A risk score based on routinely assessed clinical variables proved a good stratification for future heart failure events in diabetic patients with macrovascular disease (International Journal of Cardiology)
Comparison of efficacy between incretin-based therapies for T2D
This review is aimed to look at important mechanistic differences between incretin mimetics and enhancers through direct comparison trials and impact of these differences on biochemical, metabolic and patient satisfaction parameters (BMC Medicine)
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